Yazarlar
- Suleyman, Halis(167)
- Mammadov, Renad(95)
- Türkeş, Cüneyt(84)
- Aydin, Sonay(83)
- Altuner, Durdu(74)
- Suleyman, Bahadir(68)
- Isik, Arda(67)
- Beydemir, Şükrü(66)
- Kantarci, Mecit(64)
- Kurt, Nezahat(57)
- Demir, Yeliz(54)
- Bulut, Seval(51)
- Arslan, Yusuf Kemal(50)
- Sofu, Hakan(50)
- Coban, Taha Abdulkadir(49)
- Karakeçili, Faruk(47)
- Altay, Ahmet(46)
- Huyut, Mehmet Tahir(46)
- Aydin, Suleyman(45)
- Türkmenoğlu, Burçin(45)
- Kuzucu, Mehmet(40)
- Yazici, Gulce Naz(40)
- Peker, Kemal(39)
- Algul, Oztekin(38)
- Cicek, Betul(37)
- Mertoglu, Cuma(36)
- Camurcu, Yalkin(35)
- Suleyman, Zeynep(34)
- Bozkurt, Aliseydi(32)
- Mendil, Ali Sefa(32)
- Gunay, Murat(31)
- Gözcü, Sefa(31)
- Köksal, Ekrem(31)
- Yuca, Hafize(31)
- Dilek, Esra(30)
- Karakurt, Papatya(30)
- Ozcicek, Fatih(30)
- Süleyman, Halis(30)
- Onk, Didem(29)
- Ucpunar, Hanifi(29)
Yayınlar
- ArticleAçık Erişim2013The Role of Endothelin and Prostacyclin on Recombinant Erythropoietin-a Induced Hypertension in Hemodialysis Patients
Türkmen, Kultigin; Erdur, Fatih Mehmet; Dalmaz, Mahmut; Yeksan, Mehdi; Akkus, Idris; Türk, Suleyman
OBJECTIVE: Recombinant human erythropoietin (r-HuEPO) was found to be associated with increased blood pressure in hemodialysis (HD) patients. Plasma endothelin-1(ET-1) was reported to be increased during treatment with r-huEPO in HD patients. Prostacyclin (PGI2) was found to be associated with the reduction in vascular resistance. We aimed to determine the role of ET-1 and PGI2 on r-huEPO-induced hypertension in HD patients. MATERIAL and METHODS: 43 HD patients (19 females, 24 males) were randomly assigned to groups. Group 1 (n= 15) consisted of patients receiving r-HuEPO-a subcutaneously after each dialysis session for 6 to 42 months. Group 2 (n= 15, control group) consisted of patients who did not receive any r-huEPO and group 3 (n= 13) consisted of patients who received r-huEPO-a subcutaneously after each dialysis session for 12 weeks. Plasma ET-1,2 and 6-keto-PGF1-a were measured. RESULTS : There were no differences in terms of ET-1,2 and 6-keto-PGF1-a, systolic and diastolic BP and hematocrit levels in group 1 and group 2 patients. However, in group 3 patients, hematocrit, plasma ET1,2 and 6-keto PGF1-a levels were significantly elevated after 12 weeks of rHuEPO treatment. CONCLUSION: We showed that ET-1.2 and 6-keto-PGF1-a levels were found to be significantly increased with 12 weeks of rHu-EPO therapy in HD patients.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013An exceedingly rare localization of a brown tumor in a hemodialysis patient
Karagoz, Ali; Turkmen, Kultigin; Yazici, Raziye; Arslan, Sevket; Baktik, Suleyman; Karanis, Meryem Ilkay Eren; Altintepe, Lutfullah; Guney, Ibrahim
Brown tumor, which is seen in the context of hyperparathyroidism, is defined as a uremic bone disease characterized by increased osteoclastic activity and fibroblastic proliferation in the involved bone. In chronic renal failure, there is an excessive parathyroid hormone secretion due to hypocalcemia, hyperphosphatemia, and vitamin D deficiency. Brown tumor of the femur, facial bones, mandible, sternum, ribs, and pelvis are rare, whereas, it rarely involves sacrum. Here, we presented a brown tumor of the sacrum that developed secondary to parathyroid hyperplasia in a patient receiving hemodialysis.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Concurrent Echinococcus Disease with Colorectal Carcinoma: Reports of Two Cases
Peker, Kemal; Inal, Abdullah
Colorectal cancer (CRC) is currently the most common malignity of the gastrointestinal (GI) system in the world. CRC is the third most frequently diagnosed cancer in the U.S.A and it ranks third in cancer-related causes of death. Its etiology is complex, involving both environmental and genetic factors. Hydatid disease is an endemic disease, especially in eastern countries. E. granulosus and E. multilocularis are the most frequent types responsible for hydatidosis in human beings. Echinococcus larvae develop in cystic form, mostly in the liver or lungs. We presented two cases of rectum cancer who had co-existing liver echinococcus.
RDL Kalıcı Kaydıİncele - Review ArticleYalnız künye2013Surgical Management of Inferior Vena Cava Tumor Thrombus in Patients with Renal Cell Carcinoma
Kayalar, Nihan; Özkaynak, Berk; Gümüs, Funda; Kuplay, Huseyin; Nuhoglu, Baris; Erentug, Vedat
Renal cell carcinoma (RCC) is associated with a biological propensity for vascular invasion with extension of the tumor to the renal vein or inferior vena cava and total resection of the renal tumor and IVC tumor thrombus is considered the optimal therapy when no distant metastases are present. The surgical approach to a specific patient with RCC and IVC tumor thrombus should be selected according to the level of the tumor thrombus and the characteristics of the primary renal tumor such as size, location, regional lymphadenopathy and aberrant vascular anatomy. The surgical management of RCC and IVC tumour thrombus requires the commitment of a multidisciplinary surgical team particularly for a higher (level III and IV) tumor thrombus. Preoperative imaging is very important for the surgical planning and management. An extended chevron incision with or without a sternotomy provides excellent surgical exposure. Level 0, level I and most level II tumors can be removed using straightforward occluding maneuvers, while maintaining control of the caval thrombus and the contralateral renal vein. Vascular bypass can frequently be required for the safe and complete resection of level III tumor thrombus. The resection of level IV tumors is generally performed with the use of cardiopulmonary bypass and circulatory arrest. In this review, these surgical aspects and treatment of IVC tumor extension in patients with RCC will be summarized, hoping to provide a clear and comprehensive guideline for both urology and cardiovascular specialists.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013A Rare Case Report: Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
Karabakan, Mehmet; Akdemir, Serkan; Akdemir, Alp Ozgur; Güzel, Ozer; Çolak, Aysel
Plasmacytoid urothelial carcinoma is a rare variant of urothelial carcinoma and approximately 70 cases have been reported in the literature. This histologic variant has limited data. 46-year-old male patient who is presented with complaints about hematuria underwent transurethral resection. During the microscopic examination, specimens had plasmacytoid appearances. With chemotherapy, gemcitabine and cisplatin were administered to the patient. In this article, the diagnosis and thereatment of plasmacytoid urothelial carcinoma case that has invasion and lymphnode positivity is presented.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Renal Transplant Results of the Organ Transplant Center of Meram Medical School Between 2003-2011
Türkmen, Kultigin; Fatih, M. Ehmet Erdu R.; Erikoglu, Mehmet; Gaipov, Abduzhappar; Çolak, Bayram; Tekin, Ahmet; Yeksan, Mehdi; Selçuk, Nedim Yilmaz; Türk, Sleyman; Tavli, Sakir
BJECTIVE: Renal transplantation (RTx) is the best therapeutic modality for end-stage renal disease patients. We report 8 years single-centre experience on cadaveric and living donor RTx in terms of demographic features along with graft functions, posttransplant medical complications, patients-graft survivals. MATERIAL and METHODS: We enrolled 66 RTx (female/male: 36/30) patients including 40 cadaveric and 26 living donors. At admission age, gender, causes of renal failure, dialysis typeduration, type of RTx, induction and maintenance immunosuppressive modalities, rejection episodes, biochemistry-hemogram parameters at 1, 6, 12, 24 and 60 months after transplantation and medical complications were obtained from the medical records. RESULTS: Mean recipient age was 41 +/- 11.6 years. Mean transplant duration was 32.2 +/- 31.4 months, and the mean creatinine values was 1.4 +/- 0.9 mg/dl. The most commonly used immunosuppressive protocol was corticosteroid+tacrolimus+mycophenolate mofetil. Delayed graft function, chronic allograft nephropathy and acute rejection were observed in 27.3%, 25.7% and 13.6% of patients, respectively. 1-and 5-year patient survival rates were 100% and 100% for living donor patients and 85% and 85% for cadaveric patients, respectively. 1- and 5-year graft survival rates were 100% and 100% for living donor RTx patients, and 80% and 80% for cadaveric RTx patients, respectively. The most common medical complications were new onset diabetes mellitus and dyslipidemia. The most common early and late infection was urinary tract infection. CONCLUSION: RTx is the best renal replacement therapy in terms of patient-graft survival. However, patients should be closely moniterized for metabolic complications.
RDL Kalıcı Kaydıİncele - Book ChapterAçık Erişim2013Lung Cancer Surgery Part H: Interventional Bronchoscopy
Altin, Sedat; Balci, AE
The field of interventional bronchoscopy includes several endobronchial treatment techniques that are used to relieve obstruction of the trachea and large bronchi secondary to either benign or malignant process. Balloon dilatation, endobronchial laser therapy, electrocautery, argon plasma coagulation, cryotherapy, photodynamic therapy, brachytherapy and stent application are all frequently used in the management of these disorders. Each technique has a unique set of characteristics that may make it the more or less appropriate modality to use for a specific patient and condition. These procedures are performed using either rigid or flexible bronchoscopy depending on the particular patient and disease process involved, as well as the bronchoscopist's experience. Indications of interventional bronchoscopy are [1] malignant airway obstruction, [2] troubleshooting of benign airway obstruction, [3] foreign body aspiration, [4] hemoptysis, and [5] rarely the other applications.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Post-Traumatic Pneumoscrotum: Case Report
Peker, Kemal; Güllü, Huriye; Sahin, Murat; Issin, Ahmet
Pneumoscrotum is a rare pathology that has received little attention in the literature, although a few cases have been presented with different causes. Etiological factors that can cause pneumoscrotum include the lungs, retroperitoneal sources, surgical procedures or infections with microorganisms producing gas. A 57-year-old man was admitted to the emergency department following a motorcycle accident. He had chest excoriations and a painless crepitant scrotum. In conclusion, subcutaneous emphysema of the scrotum due to traumatic pneumothorax is not an urgent condition and assessment should be supportive with intervention directed at the etiology.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Investigation of Some Vitamin Type Inhibition on Human Cord Blood Carbonic Anhydrase I and II
Çetin, Ahmet; Çoban, Taha Abdulkadir; Çankaya, Murat; Nayki, Usmit; Kuzucu, Mehmet
Objective: Human cord blood, a specialized blood tissue, contains many substances including several enzymes which act by different biochemical reactions. Carbonic anhydrase (CA) isoenzymes are one of the most important enzyme family which are crucial for living organisms to survive. However, there is limited data regarding the effect of vitamins on CA isoenzymes. The aim of this study is to test the inhibitory effect of some widely used vitamins on human cord blood CA I and II (hcbCA I and hcbCA II). Methods: We purified hcbCA I and hcbCA II from human cord blood erythrocytes by Sepharose-4B-l-tyrosine- sulfanilamide affinity gel chromatography. The inhibitory effects of vitamin A (retinol), vitamin B12 (cyanocobalamin) and vitamin K (menadione sodium bisulfate, k3) on two isoenzyme were checked using IC50 values. Result: IC50 values for vitamin A, vitamin B12 and vitamin K were found to be 44, 90, and 31 mu M for hcbCA I and of 51, 62, and 21 mu M for hcbCA II; respectively. All these substances were found to be non-competitive inhibitors. Conclusion: Vitamins are vitally important for continuation of life and activity of some of enzymes. While the physicans recommend pregnant women to take vitamins during pregnancy, we suggest that the findings obtained in this study be taken into consideration.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Effectiveness of Intragastric Balloon Treatment for Obese Patients: Retrospective Clinical Trial
Peker, Kemal; Isik, Arda; Çimen, Orhan; Demirtas, Levent; Kuyrukluyildiz, Ufuk
Objective: Obesity is a serious and chronic disease with genetic and environmental interference. Several treatment modalities exist such as medical treatment, surgical treatment, endoscopic interventions. Methods: Thirteen patients' data were evaluated retrospectively at the Erzincan University Medical Faculty Hospital Endoscopy Unit. Intragastric balloons were performed between 2012 January-2013 December. When patients gain the desired weight, approximately 8 to 12 months later; the balloons were removed. Results: The mean duration of gastric balloons in patients was 10.0 +/- 1.22 months. It was determined that the mean weight loss within the prescribed time was 25.1 +/- 5.5 kg. There is a statistically significant difference among the values when comparing the values before and after gastric balloon (p=0.001) Conclusion: Intragastric balloon replacement is a safe and effective procedure for weight reduction. The intragastric balloon can play a role for the temporary weight reduction of morbidly obese patients in diet supporting, as well as in the preoperative treatment of patient candidates for bariatric surgery or other surgical procedures in order to decrease morbidity and mortality.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013The effect of the training given to the child development students about foreign body aspiration upon their knowledge levels
Çelik, Necla; Arikan, Duygu
Objective: This study was semi-experimentally conducted in order to determine knowledge levels of child development students about foreign body aspiration and to explore the effect of the training given to these students about foreign body aspiration upon their knowledge levels. Methods: The research was conducted with a total of 231 students who studied at the department of child development of two high schools and one vocational higher school in Erzincan Province located in the east of Turkiye between May 2011 and February 2012. The data were gathered using a questionnaire form of 38 questions. The training on foreign body aspiration (Power point presentation, video presentation and practice on a dummy) was provided in three phases. For the data evaluation; percentages, chi-square test and Mc Nemar test were used. Results: It was found out in the study that 91.8% of the students did not take any training/course about foreign body aspiration and 55% confronted situations of foreign body aspirations (ear, nose, airway).After the training about foreign body aspiration; it was noted that the number of the students who knew risky behaviors for foreign body aspiration increased and the increase in the number of the students was at the highest level among high schools (p<0.05). It was seen that the training was most effective among the university students in terms of knowing first-aid intervention in case a foreign body would obstruct airway among the children aged. <1 year (p<0.05). Conclusion: It was noted that the training which was applied on the dummy by using visual aids about foreign body aspiration increased the knowledge level of the students. Based on this finding, it may be recommended that nurses should perform their counseling and educator roles more actively for the families and those who are responsible for the baby care about foreign body aspiration by playing a more active role in the health care team.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Rare malformation of glans penis: Arteriovenous malformation
Akin, Y.; Sarac, M.; Yucel, S.
Pediatric glans penis malformations, especially arteriovenous malformations (AVM), are very rare. Herein, we report two rare cases. A 14-year-old boy attended our outpatient clinic with chief complaints of purple swelling and rapidly growing lesion on the glans penis. The lesion was excised surgically after physical and radiological evaluations. Pathology reported AVM and the patient is being followed up. The second case is a 2-year-old boy who was admitted with a big lesion involving glans penis and genital area that has been present since birth. In physical and radiological evaluations, lesion on the glans penis was pulsatile. Parents of the patient did not want any surgery and patient has been in follow-up. Diagnosis of the vascular lesions on glans penis is very easy by physical and radiological examinations today. Long-term follow-up is very important for AVM. Clinicians must make a careful effort to document new glans lesions in the pediatric population and decrease anxiety in the parents of affected children.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms i and II
Alp, Cemalettin; Maresca, Alfonso; Alp, Nurdan Alcan; Gültekin, Mehmet Serdar; Ekinci, Deniz; Scozzafava, Andrea; Supuran, Claudiu T.
Carbonic anhydrase inhibitors of primary sulfonamide type, RSO2NH2, have clinical applications as diuretics, antiglaucoma, antiepileptic, antiobesity and antitumor drugs. Here we investigated inhibition of two human cytosolic isozymes, hCA I and II, with a series of secondary/tertiary sulfonamides, incorporating tosyl moieties (CH3C6H4SO2NR1R2). Most compounds inhibited both isoforms in low micromolar range, with inhibition constants between 0.181-6.01 μM against hCA I, and 0.209-0.779 μM against hCA II, respectively. These findings point out that substituted benzenesulfonamides may be used as leads for generating interesting CAIs probably possessing a distinct mechanism of action compared to primary sulfonamides. Indeed, classical RSO2NH2 inhibitors bind in deprotonated form to the Zn(II) ion from the CA active site and participate in many other favorable interactions with amino acid residues lining the cavity. The secondary/tertiary sulfonamides cannot bind to the zinc due to steric hindrance and probably are accommodated at the entrance of the active site, in coumarin binding-site.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013Mapping corneal thickness using dual-scheimpflug imaging at different stages of keratoconus
Demir, Selim; Ortak, Hüseyin; Yeter, Volkan; Alim, Sait; Sayn, Osman; Taş, Ufuk; Sönmez, Barş
Purpose: To map the thickness of the entire cornea using dual-Scheimpflug imaging and to evaluate the changes in the corneal thickness over the entire cornea at different stages of keratoconus. Methods: Corneal pachymetry was performed using the Galilei dual-Scheimpflug analyzer. The thinnest (TCT), central (CCT), paracentral (PaCT), and peripheral corneal thicknesses (PeCT) were also analyzed. The study examined 150 eyes of 150 patients who had myopia or myopic astigmatism and 107 eyes of 75 patients with keratoconus. Of these 107 eyes, 48 were evaluated at stage I keratoconus, 32 at stage II, 12 at stage III, and 15 at stage IV keratoconus. The level of severity of the keratoconus was based on the Amsler-Krumeich classification. Results: There were significant decreases in the thickness values of the entire corneas at all the different stages of progression defined in the Amsler-Krumeich classification. Analysis of the receiver operating characteristic curve showed that the TCT provided a better parameter than did the CCT, PaCT, and PeCT for distinguishing between keratoconus at its different stages and myopic eyes. Although the TCT and CCT parameters provided an effective distinction of eyes with stage II, III, and IV keratoconus from normal eyes, they were not effective for discriminating eyes with stage I keratoconus from eyes with myopia. But, PaCT and PeCT parameters enabled the effective discrimination between eyes with stage IV keratoconus and those with myopia only. Conclusions: The data obtained by dual-Scheimpflug imaging for the corneal thicknesses of the entire cornea provide useful information for grading the severity of keratoconus.
RDL Kalıcı Kaydıİncele - LetterAçık Erişim2013Platelet-to-lymphocyte ratio: One of the novel and valuable platelet indices in hemodialysis patients
Turkmen, Kultigin
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013The effect of first dose of tamsulosin on flow rate and its predictive ability on the improvement of LUTS in men with BPH in the mid-term
Akin, Yigit; Gulmez, Hakan; Ucar, Murat; Yucel, Selcuk
Purpose To investigate if effects of the first single dose of tamsulosin 0.4 mg on uroflowmetry parameters would predict treatment response at the third month. Methods Men over 40 years old with complaints of lower urinary tract symptoms associated with benign prostatic hyperplasia were studied with physical examination, urine and blood analysis, uroflowmetry (UFM), post-voiding residual urine volume (PVR), international prostate symptom score (IPSS), qualityof- life (QoL) index and transrectal prostate ultrasonography (TRUS), and patients with prostate cancer suspicion, past urinary surgery, urinary tract infection and neurologic diseases were excluded. UFM, PVR, IPSS, QoL were repeated at 6th hour of the first day, first month and third month of oral tamsulosin 0.4 mg treatment. All parameters were recorded as baseline, and changes in the UFM parameters, PVR, IPSS and QoL were evaluated in clinical visits. Results As a total, 48men (mean 60.17 ± 1.18 years) were recruited. There was a significant increase in maximumurine flow rate (Q max) and average urine flow rate (Qave) and decrease in PVR from baseline with the first dose of tamsulosin as well as first and third month of treatment (p<0.05). IPSS andQoL scores significantly improved at the first month in correlation with UFM parameters. Tamsulosin treatment was effective in 33 (68.7 %) patients at the first administration and 35 (72.9 %) at the third month. Positive predictive value and negative predictive value ofQmax change at first dose for the third month response rate were 90.9 and 66.6 %, respectively. Conclusions The mid-term effectiveness of tamsulosin may be predicted by changes in UFM parameters achieved with its first dose.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Comparison of vessel sealing systems with conventional
Peker, Kemal; Inal, Abdullah; Güllü, Huriye; Gül, Düriye; Şahin, Murat; Ozcan, Ayca Dumanli; Kiliç, Kemal
Background: Haemorrhoids are cushions of submucosal vascular tissue located in the anal canal starting just distal to the dentate line. Haemorrhoidal disease is a common anorectal disorder which has symptoms of bleeding, prolapse, pain, thrombosis, mucus discharge, and pruritus. Haemorrhoidectomy is one of most frequently performed anorectal operation worldwide. Objectives: The aim of this study was to compare the effectiveness of the LigaSure tissue sealing device, Harmonic Scalpel and conventional MM open haemorrhoidectomy. Materials and Methods: Sixty-nine patients with newly diagnosed symptomatic grade three or grade four haemorrhoidal disease, from July 2011 to December 2011 were recruited for the study. Patients were prospectively randomized to LigaSure, Harmonic Scalpel and conventional haemorrhoidectomy. Patients were evaluated on the basis of the mean operative time, postoperative pain, day of discharge, early and late complications. Results: Each group has twenty-three patients. Ten (14.5 %) were female and fifty-nine (85.5 %) were male. Mean age were 44.5 ± 10.8 for LigaSure group, 39.5±14.4 for Harmonic Scalpel group and 39.8 ± 13.6 for conventional haemorrhoidectomy group. Mean operative time was 12.6 ± 2.9 for LigaSure group, 12.6 ± 2.5 for Harmonic Scalpel group and 22.3 ± 4.5 for conventional haemorrhoidectomy group. Postoperative pain and required analgesic dose were significantly lower for conventional haemorrhoidectomy. Wound healing was also more rapid in conventional haemorrhoidectomy than both LigaSure and Harmonic Scalpel. Conclusions: Lateral heat dissipation of energy based cautery such as Harmonel Scalpel and LigaSure is considerably high when compared with conventional methods. More thermal damage which is generated on tissue seems to be the reason for increased degree of postoperative pain and delay in wound healing.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2013Fatigue, anxiety and depression levels, activities of daily living of patients with chronic obstructive pulmonary disease
Karakurt, Papatya; Ünsal, Ayla
The aim of this cross-sectional study was to determine the fatigue, anxiety and depression levels, activities of daily living of patients with chronic obstructive pulmonary disease (n=255). It was found that there was significant difference between Visual Analogue Scale for Fatigue (VAS-F) point averages and gender, education levels, marital status and economical status of patient with chronic obstructive pulmonary disease. Among the participants in this study, 36.5% had an anxiety disorder whereas 69.0% exhibited depression. In the study, it was determined that 85.5% of those were independent in their Katz's Index of Activities of Daily Living (ADLs) and 49.4% of those were independent in their Lawton and Brody's Index of Instrumental Activities of Daily Living (IADLs). This study has shown that VAS-F, the Hospital Anxiety and Depression Scale, ADL and IADL instruments that measure the various aspects of health-related quality of living can contribute considerably to a more diversified understanding of the patients' situation with chronic obstructive pulmonary disease.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running
Aydin, Suleyman; Aydin, Suna; Kuloglu, Tuncay; Yilmaz, Musa; Kalayci, Mehmet; Sahin, Ibrahim; Cicek, Demet
The purpose of this study was to ascertain (1) whether human saliva contains irisin and whether its level correlates with serum irisin concentration, (2) whether salivary glands, eccrine glands and sebaceous glands in human skin produce irisin, (3) how the changes in saliva and serum irisin concentrations after the Turkish bath at 47 ± 3 C compare with the changes caused by moderate exercise in obese and normal weight subjects. Seven obese male subjects and seven normal weight subjects were enrolled for Turkish bath. Seven obese male subjects and seven normal weight subjects were also enrolled for moderate outdoor exercise, and thirteen male normal weight subjects neither exercised nor showered at the Turkish bath. From each participant, 1.5 ml of saliva and 5 ml blood were collected simultaneously before and after the moderate exercise and Turkish bath. Salivary glands and eccrine and sebaceous glands in the skin were screened immunohistochemically for irisin while serum and saliva irisin were measured with an ELISA. Submandibular glands, eccrine glands and sebaceous glands in the human skin showed strong irisin immunoreactivity. Human saliva contained irisin and its level was significantly higher than the serum levels in both obese and normal weight subjects. However, irisin concentrations were more markedly increased in both saliva and serum samples from subjects who had showered at a Turkish bath than in obese subjects who had exercised or in normal weight subjects. Human submandibular glands, eccrine sweat glands and sebaceous glands synthesize irisin.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum
Gungor, Sami; Gurates, Bilgin; Aydin, Suleyman; Sahin, Ibrahim; Kavak, Salih Burçin; Kumru, Selahattin; Celik, Husnu; Aksoy, Aziz; Yilmaz, Musa; Catak, Zekiye
Objectives: The goal of this study was to compare levels of acyl and des-acyl ghrelin, obestatin, nesfatin-1 and leptin in healthy gravidas to hyperemesis gravidarum (HG) patients. Design and methods: Twenty pregnant women with HG and twenty healthy pregnant women all of similar ages, BMI and all at similar pregnancy development comprised the study cohort. Fasting serum samples were obtained and measured for acyl and des-acyl ghrelin, leptin, obestatin and nesfatin-1. Results: Nesfatin-1 concentrations in the HG group were higher compared to the control group whereas; leptin concentrations during pregnancy were lower in the HG group as compared to the control group. The two groups did not differ with regard to acyl and des-acyl ghrelin and obestatin. Conclusion: This pilot study suggests a possible role of leptin and nesfatin-1, which might be involved in the pathology of the disease.
RDL Kalıcı Kaydıİncele
