Yazarlar
- Suleyman, Halis(167)
- Mammadov, Renad(95)
- Türkeş, Cüneyt(84)
- Aydin, Sonay(83)
- Altuner, Durdu(74)
- Suleyman, Bahadir(68)
- Isik, Arda(67)
- Beydemir, Şükrü(66)
- Kantarci, Mecit(64)
- Kurt, Nezahat(57)
- Demir, Yeliz(54)
- Bulut, Seval(51)
- Arslan, Yusuf Kemal(50)
- Sofu, Hakan(50)
- Coban, Taha Abdulkadir(49)
- Karakeçili, Faruk(47)
- Altay, Ahmet(46)
- Huyut, Mehmet Tahir(46)
- Aydin, Suleyman(45)
- Türkmenoğlu, Burçin(45)
- Kuzucu, Mehmet(40)
- Yazici, Gulce Naz(40)
- Peker, Kemal(39)
- Algul, Oztekin(38)
- Cicek, Betul(37)
- Mertoglu, Cuma(36)
- Camurcu, Yalkin(35)
- Suleyman, Zeynep(34)
- Bozkurt, Aliseydi(32)
- Mendil, Ali Sefa(32)
- Gunay, Murat(31)
- Gözcü, Sefa(31)
- Köksal, Ekrem(31)
- Yuca, Hafize(31)
- Dilek, Esra(30)
- Karakurt, Papatya(30)
- Ozcicek, Fatih(30)
- Süleyman, Halis(30)
- Onk, Didem(29)
- Ucpunar, Hanifi(29)
Yayınlar
- ArticleAçık Erişim2014Comparison of different legation techniques in laparoscopic varicocelectomy
Akin, Yiǧit; Ateş, Mutlu; Yücel, Selçuk; Başara, Işil; Çelik, Orçun; Bozkurt, Aliseydi; Nuhoǧlu, Bariş
Aim: To evaluate the effects of different intracorporeal legation techniques with titanium clips, Plasma Trisector (Gyrus, USA) (PTG), and surgical silk on bilateral laparoscopic varicocelectomy (LPVx). Materials and methods: Between May 2009 and August 2012, 100 patients who underwent bilateral LPVx were evaluated. Te demographic parameters of patients, preoperative radiological findings, semen analysis, operative data, and follow-up were recorded. All of the patients were divided into 3 groups, randomized prospectively. Te patients whose veins were legated by 5-mm titanium clips were included in group I, those whose veins were legated by PTG were included in group II, and those whose veins were legated by surgical silk were included in group III. Te recorded data of the groups were analyzed. Results: Mean follow-up time was 18.8 ± 1.1 months. According to the demographics of age, body mass index, spermiogram, and diameter of veins before surgery, there were no statistical differences between any of the groups (P > 0.05). However, operation time was longer in group III (P < 0.0001), while total numbers of legated veins did not differ among the groups (P > 0.05). Additionally, hospital stay, oral intake, and complications were not different among the groups (P > 0.05). In follow-up the sperm count analysis was higher than the preoperative count analysis for all of the groups (P < 0.05). Conclusion: PTG may provide a shorter operation time than using titanium clips and/or surgical silk in LPVx. Additionally, PTG may increase sperm count with fewer complications than the other legation techniques in LPVx. Terefore, PTG may be the new candidate electrosurgical standard device for LPVx in the nearby future.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Clinical results of anterior odontoid screw fixation for type II odontoid fractures
Keskin, Fatih; Gomleksiz, Cengiz; Sasani, Mehdi; Oktenoglu, Tunc; Suzer, Tuncer; Ozer, Ali Fahir
Aim: In this study, 31 patients with a diagnosis of Type II odontoid fractures were reported. All patients were treated with anterior transodontoid screw fixation and clinical outcomes were reported. Mater Ial and Meth ods: In this study, the retrospective clinical analysis of 31 patients with traumatic type II odontoid fractures who were treated through anterior transodontoid fixation in Neurosurgery Department at VKV American Hospital between 1998 and 2012 was performed. The age, sex, cause of injury, diagnosis time, neurological examination before and after surgery, follow-up period were evaluated. The neurological status of patients was classified according to the Frankel scale. Result s: In 4 patients, 2 transodontoid screws were inserted. The mean hospital stay was 3.35 days. Posterior occipito-cervical fusion was done in 1 patient due to the lack of fusion in the first operation. No vascular injury, screw malposition, infection, neurologic deterioration, or complications were observed during the peroperative and postoperative stage. The mean postoperative follow-up period was 36 months after surgery. Radiological imaging of patients were performed at the early and late postoperative stage. Conclusion: We found satisfying fusion rates and better patient comfort during the postoperative period. We think that stabilization and fusion through a transodontoid screw is a minimal invasive method.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Bone marrow metaplasia in multinodular goiter with primary hyperparathyroidism
Sayar, Ilyas; Isik, Arda; Akbas, Emin Murat; Eken, Huseyin; Demirtas, Levent
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Frequency, awareness, treatment and control of hypertension in the over 40 population of Erzincan; [Erzincan’da Kırk yaş ve üzeri bireylerde hipertansiyon sıklığı, farkındalığı, tedavisi ve kontrolü]
Aşılar, Rabia Hacıhasanoğlu; İnandı, Tacettin; Yıldırım, Arzu; Karakurt, Papatya; Sağlam, Rabia
RESULTS: The overall hypertension frequency was 67.0% (69.6% in women and 63% in men). In the study sample, 77.4% of individuals were aware of their hypertension, all were receiving anti-hypertensive drugs, and 33.9% of patients had their blood pressure under control. Among all hypertensive individuals, the percentage of controlled hypertension (HT) was 26.2%. The frequency of hypertension was associated with age, body mass index (BMI), smoking, level of education, the use of salt, and diabetes.; AIM: The aim of this study is to determine the frequency, awareness, treatment and control of hypertension in population over 40 years of age who came to the 5 primary health care centers in Erzincan for any reason.; METHODS: This cross-sectional study was completed with 1570 people aged 40 and older, who received care at health care centers between January and May 2009. The data were collected through face-to-face interviews, and blood pressures were measured twice. Participants were considered as hypertensive if their average systolic blood pressure was ≥140 mmHg, or their average diastolic blood pressure was ≥90 mmHg, or if they were taking antihypertensive medication. The awareness, treatment and control status of the individuals were also assessed.; CONCLUSION: These results indicate that the frequency of HT was high, and it was inadequately managed in individuals who came to the primary healthcare centers for any reason and received treatment. Many of the individuals were not aware of their illness. Therefore, it becomes very important and necessary to ensure early diagnosis and control of hypertension and to develop strategies to increase awareness.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Maternal magnesium level effect on preterm labor treatment
Uludaǧ, Eda Ülkü; Gözükar, Ilay Öztürk; Kucur, Suna Kabil; Uluǧ, Paşa; Özdeǧirmenci, Özlem; Erkaya, Salim
Objective: To compare the initial serum magnesium levels between preterm labor (PL) and control groups and to evaluate MgSO4 treatment response in preterm labor group according to their initial serum magnesium levels. Methods: Hundred women diagnosed as preterm labor between 28 and 33 weeks of gestation and 100 non-complicated pregnant women were enrolled in this prospective study. Total basal serum magnesium levels were measured in both the groups. After a 6 g intravenous bolus of MgSO4, a dose of 2 g/h was given as an infusion in the preterm labor group. Results: Serum magnesium levels were significantly lower in preterm labor group (p50.001). The active contractions stopped in 69 (73,4%) preterm patients. The basal Mg level was significantly lower in this preterm group (1.6 versus 1.9, respectively, p50.001). Predictive value of basal magnesium level measurement for magnesium tocolysis response was calculated by receiver operating characteristic analyses with 95% confidence interval. Positive predictive and negative predictive values were found as 64.5% and 92.5%, respectively, with 83% accuracy, when cut-off magnesium value was taken as a 51.75 mg/dl (sensitivity=80%, specificity=84,1%). Conclusions: Basal magnesium levels in preterm labor had a predictive value in evaluating MgSO4 tocolysis response. It may help to select patients who are appropriate for MgSO4 tocolysis.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014The approach of general surgeons to oncoplastic and reconstructive breast surgery in Turkey: A survey of practice patterns
Emiroğlu, Mustafa; Sert, İsmail; İnal, Abdullah; Karaali, Cem; Peker, Kemal; İlhan, Enver; Gülcelik, Mehmet; Erol, VarlıK; Güngör, Hilmi; Can, Didem
Background: Oncoplastic Breast Surgery (OBS), which is a combination of oncological procedures and plastic surgery techniques, has recently gained widespread use.; Aims: To assess the experiences, practice patterns and preferred approaches to Oncoplastic and Reconstructive Breast Surgery (ORBS) undertaken by general surgeons specializing in breast surgery in Turkey.; Study Design: Cross-sectional study.; Methods: Between December 2013 and February 2014, an elevenquestion survey was distributed among 208 general surgeons specializing in breast surgery. The questions focused on the attitudes of general surgeons toward performing oncoplastic breast surgery (OBS), the role of the general surgeon in OBS and their training for it as well as their approaches to evaluating cosmetic outcomes in Breast Conserving Surgery (BCS) and informing patients about ORBS preoperatively.; Results: Responses from all 208 surgeons indicated that 79.8% evaluated the cosmetic outcomes of BCS, while 94.2% informed their patients preoperatively about ORBS. 52.5% performed BCS (31.3% themselves, 21.1% together with a plastic surgeon). 53.8% emphasized that general surgeons should carry out OBS themselves. 36.1% of respondents suggested that OBS training should be included within mainstream surgical training, whereas 27.4% believed this training should be conducted by specialised centres.; Conclusion: Although OBS procedure rates are low in Turkey, it is encouraging to see general surgeons practicing ORBS themselves. The survey demonstrates that our general surgeons aspire to learn and utilize OBS techniques.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Reliability and validity of the Turkish form of the eight-item morisky medication adherence scale in hypertensive patients
Aşılar, Rabia HacıhasanoğLu; Gözüm, Sebahat; Çapık, Cantürk; Morisky, Donald E.
Objective: The aim of this study is to evaluate the reliability and validity of the Turkish version of the 8-item Morisky medication adherence scale. Methods: The study was conducted as a methodological design. The study included 196 patients with hypertension who applied to the Family Health Centers in three different regions of Turkey. Data were collected from February-June 2012.; Methods used in the analysis included factor analysis, assessment of Cronbach’s α test and item-total correlation in order to perform psychometric measurements. Variables influencing scores of medication adherence were determined using logistic regression analysis.; Results: Factor loadings of all items in the scale were above 0.40, and the variation explained was determined to be 42.4. The Turkish form consisted of a single domain. The Cronbach’s α coefficient of the items in the scale was 0.79. Item-total correlations of items in the scale were between 0. 30 and 0. 62. Scores of medication adherence were observed to be affected by low economic condition and city where said individuals reside.; Conclusion: It was determined that levels of reliability and validity of Turkish version of 8-item Morisky medication adherence scale is acceptable.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Very long-term angiographic results of off-pump coronary artery bypass graft surgery
Özkaynak, Berk; Yildirim, özgür; Aksüt, Mehmet; Onk, Oruç Alper; Kayalar, Nihan; Ömeroglu, Suat Nail; Erentug, Vedat; Yakut, Cevat
Background: This study aims to evaluate the long-term results of angiography in patients undergoing off-pump coronary artery bypass grafting (CABG). Methods: Between September 1993 and December 1995, a total of 162 patients who underwent off-pump CABG by the same two surgeons at a single center, followed by angiography were retrospectively analyzed. Results: The mean time from surgery to angiography was 9.8±1.2 years (range, 7.1 to 12.6 years). The overall patency rate of the left internal mammary artery graft was 95.57% and 46.03% in saphenous vein grafts (SVG). During follow-up, 27 patients (16.67%) underwent percutaneous coronary intervention. The procedure was performed due to severe stenosis in the SVG in eight of them and due to severe lesion formation in native coronary artery in the others. Five patients underwent repeated CABG. There was no significant association between pre-, intra-, and postoperative variables and graft patency. Conclusion: Off-pump CABG technique, in contrast to the conventional bypass, has well-known advantages such as lower transfusion of blood and blood products, shortened length of intensive care unit and hospital stay, reduced cost, and lower morbidity and mortality. Our very long-term angiographic follow-up study showed that off-pump CABG is as reliable as conventional bypass procedure with excellent outcome and patency particularly in the left anterior descending coronary artery. Therefore, off-pump CABG technique should be the primary procedure of choice in selected patients.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014An extremely rare manifestation of Behcet's disease: Urethrovaginal fistula
Akin, Yigit; Yucel, Selcuk; Baykara, Mehmet
Behcet's disease (BD) is a rare chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. However, the etiopathogenesis of the disease remains unknown, and diagnosis is basically dependent on clinical manifestations. Sometimes BD may be diagnosed with rare clinical entities. Herein, we presented an extremely rare case of urethrovaginal fistula which has been diagnosed as manifestation of BD. After surgical treatment of fistula, there was no complication in 6 months following surgical repair and the follow-up period has been going on.
RDL Kalıcı Kaydıİncele - Conference ObjectYalnız künye2014Balloon tamponade for the management of postpartum uterine hemorrhage
Kaya, Bariş; Tuten, Abdullah; Daglar, Korkut; Misirlioglu, Mesut; Polat, Mesut; Yildirim, Yusuf; Unal, Orhan; Kilic, Gokhan Sami; Guralp, Onur
Objective: To evaluate the use of the Bakri balloon in postpartum hemorrhage (PPH) resistant to medical treatment. Methods: The Bakri balloon was applied to 45 women with PPH after failure of initial management. Bilateral internal iliac artery ligation (BIIAL) and hysterectomy were performed if necessary. Results: The Bakri balloon was applied in 45 women; an additional BIIAL was required in nine women. The mean inflation volume of the Bakri balloon was 571±264 mL (range: 240-1300 mL). Hemostasis was achieved in 34 (75.5%) women with the Bakri balloon alone, and in six women with an additional BIIAL. The Bakri balloon was effective with additional procedures overall in 40 of 45 (88.8%) women. In 34 women with uterine atony, the Bakri balloon was successful alone in 27 (79.4%) and with an additional BIIAL in 30 (88.2%) women. An inflation volume of >500 mL was necessary in 18 women with uterine atony. Conclusion: The Bakri balloon may be performed as a first line of treatment for PPH resistant to uterotonic agents, and can be used not only in tertiary centers but also in limited-resource centers. The inflation volume of the Bakri balloon should be adjusted according to the type of PPH; a volume exceeding 500 mL may be necessary in uterine atony.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Importance of metastatic lymph node ratio in non-metastatic, lymph node-invaded colon cancer: A clinical trial
Isik, Arda; Peker, Kemal; Firat, Deniz; Yilmaz, Bahri; Sayar, Ilyas; Idiz, Oguz; Cakir, Coskun; Demiryilmaz, Ismail; Yilmaz, Ismayil
Background: The aim of this study was to evaluate the prognostic importance of the metastatic lymph node ratio for stage III colon cancer patients and to find a cut-off value at which the overall survival and disease-free survival change. Material/Methods: Patients with pathological stage III colon cancer were retrospectively evaluated for: age; preoperative values of Crp, Cea, Ca 19-9, and Afp; pathologic situation of vascular, perineural, lymphatic, and serosal involvement; and metastatic lymph node ratio values were calculated. Results: The study included 58 stage III colon cancer patients: 20 (34.5%) females and 38 (65.5%) males were involved in the study. Multivariate analysis was applied to the following variables to evaluate significance for overall survival and disease-free survival: age, Crp, Cea, perineural invasion, and metastatic lymph node ratio. The metastatic lymph node ratio (<0.25 or ≥0.25) is the only independent variable significant for overall and diseasefree survival. Conclusions: Metastatic lymph node ratio is an ideal prognostic marker for stage III colon cancer patients, and 0.25 is the cut-off value for prognosis.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Determination of correlation among heart rate variability, left atrium global strain, and nighttime blood pressure among patients with tinnitus
Değirmenci, Hüsnü; Bakırcı, Eftal Murat; Salcan, İsmail; Demirelli, Selami; Duman, Hakan; Ceyhun, Gökhan; Küçüksu, Zafer
Background: We aimed to examine the correlation among nighttime blood pressure, heart rate variability, and left atrium peak systolic global longitudinal strain among patients with subjective tinnitus.; Material/Methods: Eighty patients with tinnitus were assigned to Group 1 and 80 healthy individuals were assigned to Group 2. Clinical blood pressure measurements, ambulatory blood pressure monitoring, and Holter electrocardiography monitoring were performed. All of the cases included in the study were examined with conventional echocardiography and 2-dimensional speckle tracking echocardiography.; Results: Mean nighttime systolic blood pressure (130.3±5.4) and mean nighttime diastolic blood pressure (82.8±3.9) in Group 1 were higher than in Group 2 (125.1±5.4 and 80.7±4.7, respectively) (p<0.05). Mean heart rate in Group 1 was significantly lower than in Group 2 but there was no statistically significant difference between the groups in terms of heart rate variability parameters and left atrium peak systolic global longitudinal strain values (p>0.05).; Conclusions: Nighttime systolic blood pressure and nighttime diastolic blood pressure were higher among the patients with tinnitus. In light of these results, we can conclude that both clinical blood pressure measurement and ambulatory blood pressure monitoring are important for patients with tinnitus.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014A 9-kg ovarian mucinous cystadenoma in a 14-year-old premenarchal girl
Biçer, Şenol; Erkul, Zehra; Demiryilmaz, Ismail; Peker, Necla
Objective: Rare disease Background: Although ovarian tumors are most commonly observed in adults, they relatively rarely occur in children. The majority of ovarian masses encountered in the premenarchal or childhood stages are non-neoplastic lesions such as benign functional cysts. Epithelial tumors account for 8-10% of all ovarian tumors and are histologically classified as mucinous or serous. The most common benign epithelial ovarian tumor is cystadenoma. Case Report: We report the case of a 14-year-old premenarchal girl with chronic abdominal pain, constipation, and abdominal enlargement. A computed tomography detected a huge left ovarian cystic tumor. A 9-kg ovarian tumor was removed surgically. Pathology showed a benign mucinous cystadenoma (MCA). Conclusions: Ovarian neoplasms in children present a diagnostic quandary, and very often the diagnoses are missed or delayed. When the diagnosis is made, a prompt and fertility-preserving surgical treatment must be performed and followed to prevent recurrence.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Predictors of epicardial adipose tissue in patients with type 2 diabetes mellitus
Akbas, Emin M.; Hamur, Hikmet; Demirtas, Levent; Bakirci, Eftal M.; Ozcicek, Adalet; Ozcicek, Fatih; Kuyrukluyildiz, Ufuk; Turkmen, Kultigin
Background: Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were introduced as potential markers to determine inflammation in various disorders. Recently, atherogenic index of plasma (AIP) was found to be closely associated with atherosclerosis in general population. Waist circumference is commonly used to assess the risk factors in various metabolic disorders. There has been a well known relation between inflammation and peripheral adipose tissue in diabetes mellitus. However, the data regarding EAT and inflammation is scant in this population. Hence, we aimed to determine the relationship between PLR, NLR, AIP, waist circumference and EAT in diabetic patients. Methods. This was a cross-sectional study involving 156 patients with type 2 diabetes mellitus (87 females, 69 males; mean age, 53.62 ± 9.33 years) and 50 control subjects (35 females, 15 males; mean age, 51.06 ± 8.74 years). EAT was measured by using a trans-thoracic echocardiogram. Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum triglyceride to high density lipoprotein (HDL)cholesterol. NLR and PLR were calculated as the ratio of the neutrophils and platelets to lymphocytes, respectively. Results: Waist circumference, PLR, NLR, AIP and EAT measurements were significantly higher in diabetic patients when compared to control subjects. When diabetic patients were separated into two groups according to their median value of EAT (Group 1, EAT < 4.53 (n = 78) and group 2, EAT ≥4.53 (n = 78)), group 2 patients had significantly higher Body mass index (BMI), waist circumference, AIP, NLR and PLR levels. In the bivariate correlation analysis, EAT was positively correlated with PLR, NLR, AIP, BMI and waist circumference (r = 0.197, p = 0.014; r = 0.229, p = 0.004; r = 0.161, p = 0.044; r = 0.248, p = 0.002; r = 0.306, p < 0.001, respectively). Waist circumference was found to be independent variables of EAT. Conclusions: Simple calculation of PLR and measurement of waist circumference were found to be associated with increased EAT in diabetic patients.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Esophageal rupture complicated by acute pericarditis
Duman, Hakan; Bakirci, Eftal Murat; Karadaʇ, Zakir; Uʇurlu, Yavuz
Esophageal perforation is a serious condition with a high mortality rate. Delayed detection of esophageal perforation may result in devastating complications such as mediastinitis and pericarditis. Esophageal perforation is rarely due to aspiration of foreign bodies. Here we report the case of a 59-year-old male patient with complicated esophageal perforation due to ingestion of a chicken bone, whose first signs are considered to be acute non-specific pericarditis.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Evaluation of the temperament and character properties of patients with ankylosing spondylitis; [Bestimmung der Temperaments- und Charaktereigenschaften von Patienten mit ankylosierender Spondylitis]
Gokmen, F.; Altinbas, K.; Akbal, A.; Celik, M.; Savas, Y.; Gökmen, E.; Reşorlu, H.; Karaca, A.
Purpose: The aim of this study was to evaluate temperament and character of ankylosing spondylitis (AS) patients and to examine the association between these specific temperament and character properties and clinical variables.; Patients and methods: This study involved 73 AS patients. Temperament properties of patients were evaluated using Cloninger’s Temperament and Character Inventory (TCI). Association between clinical variables and specific temperament features were evaluated using correlation and regression analyses.; Results: Forty eight (65.8 %) of the study participants were men and the mean age was 42 ± 11.4 years. There was slight negative correlations between self directedness (S) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (p = 0.01, r = − 0.30), and between the Visual Analog Scale (VAS) and reward dependence (RD) scores (p = 0.03, r = − 0.26). Regression analysis showed that correlations between BASDAI and S, and between VAS and RD scores were statistically significant.; Conclusion: Our study showed that the dimensions temperament and character are related to disease activation, and disease course is more severe in patients who have low scores in these TCI dimensions. Therefore, we suggest that evaluating temperament and character properties of AS patients will help clinicians to predict treatment compliance and motivation of patients during disease course.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Damage induced by paracetamol compared with N-acetylcysteine
Kisaoglu, Abdullah; Ozogul, Bunyami; Turan, Mehmet Ibrahim; Yilmaz, Ismayil; Demiryilmaz, Ismail; Atamanalp, Sabri Selcuk; Bakan, Ebubekir; Suleyman, Halis
Background: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods: Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine+paracetamol, TPP+paracetamol, and N-acetylcysteine+paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results: The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion: Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Evaluation of the effects of single or multiple dose methotrexate administration, salpingectomy on ovarian reserve of rat with the measurement of anti-Müllerian hormone (AMH) levels and histological analysis
Ulug, Pasa; Oner, Gokalp
Study design: In this prospective controlled experimental study, forty female Wistar-albino rats were randomly divided into four groups; healthy control group (group 1), one month after single dose (50 mg/ m2) MTX administration group (group 2), multiple (1 mg/kg, 1, 3, 5, 7 days) dose MTX administration group (group 3), and unilateral salpingectomy applied group (group 4). Ovarian reserves were assessed with anti-Mu llerian hormone (AMH) and ovarian follicles including primordial, primary, secondary, tertiary and total follicle counts.; Setting: Kobay and Duzen experimental research laboratory.; Results: Serum AMH levels decreased significantly in the single and multiple dose MTX administration group and salpingectomy group compared with control group. Primordial follicle counts were comparable between single dose MTX group and control group whereas all type of follicle counts in single and multiple dose MTX and salpingectomy group were significantly reduced compared with control. The least affected ovarian reserve in the treatment groups was single dose MTX group.; Conclusions: Ovarian reserve markers including follicle counts and AMH levels were decreased after single, multiple dose MTX administration, and salpingectomy. Single dose MTX was the least detrimental method on ovarian reserve for the treatment of ectopic pregnancy.; Objective: To evaluate the effects of single, multiple dose methotrexate (MTX) administration and salpingectomy on ovarian reserve in a rat model.
RDL Kalıcı Kaydıİncele - Review ArticleYalnız künye2014Fully endoscopic interlaminar and transforaminal lumbar discectomy: Short-term clinical results of 163 surgically treated patients
Sencer, Altay; Yorukoglu, Ali Guven; Akcakaya, Mehmet Osman; Aras, Yavuz; Aydoseli, Aydin; Boyali, Osman; Sencan, Fahir; Sabanci, Pulat Akin; Gomleksiz, Cengiz; Imer, Murat
Objective To evaluate the clinical outcomes of patients with lumbar disc disease undergoing fully endoscopic surgery at a single clinic; Methods Between August 2009 and January 2012, 163 patients (74 men and 89 women) underwent fully endoscopic lumbar discectomy. All patients were followed for 1 year after surgery. The Oswestry Disability Index and a visual analog scale were used to analyze outcomes.; Conclusions Fully endoscopic interlaminar or transforaminal surgeries are safe and effective treatment modalities for lumbar disc herniations. Despite the difficulties of acquiring this new technique, good results can be achieved with sufficient experience.; Results During the follow-up period, 114 (70%) patients had no complaints, 30 (18%) patients had occasional pain, and 19 (12%) patients had no improvement. During postoperative follow-up, 8 patients required repeat surgery for recurrence or residual fragments. Postoperatively, 4 patients experienced dysesthesia, which completely resolved in time. Neurologic deterioration occurred in 5 patients, 4 of whom recovered completely without any intervention. Dural tears occurred in 6 patients.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014The diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors
Peker, Kemal; Sayar, Ilyas; Gelincik, Ibrahim; Bulut, Gülay; Ünal, Tuba Dilay Kökenek; Şenol, Serkan; Gökçe, Aysun; Isik, Arda
Background: The importance of the matrix metalloproteinase-7 (MMP-7) and nestin immunomarkers, C-kit proto-oncogene (CD117), and the efficiency of the Ki-67 proliferation index for gastrointestinal stromal tumors were evaluated. Material/Methods: This study was conducted by examining the microscope slides of 72 patients with gastrointestinal stromal tumors that were sent to the pathology laboratory between 2007 and 2012. Immunohistochemical staining for CD117, MMP-7, nestin, and marker of proliferation Ki-67 was performed. The correlations between the positive results for Ki-67, CD117, MMP-7, and nestin were evaluated relative to the tumor characteristics of size, localization, grade, cellular type, cellularity, cytology type, growth pattern, ulceration, necrosis, hemorrhage, invasion depth, and lymph node metastasis. Results: The tumor was localized in the stomach in 42 of the patients, the intestines in 19, the colon in 7, and the rectum in 4. Comparisons among the groups showed that MMP-7 was correlated with the tumor grade (p<0.001), cellularity (p<0.009), cytologic atypia (p<0.001), ulceration (p=0.002), necrosis (p<0.001), and tumor size (p=0.001). Nestin was correlated with the tumor grade (p=0.013), and tumor size (p=0.024). Correlations among CD117, MMP-7, nestin, and Ki-67 were examined. Nestin and Ki-67 were both significantly correlated with CD117 and MMP-7 [(r=0.279, p=0.018), (r=0.322, p=0.006), (r=0.386, p=0.001), (r=0.386, p=0.002)], respectively. Conclusions: MMP-7 and nestin may be beneficial as markers, given their sensitivity to gastrointestinal stromal tumors.
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