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ArticleYalnız künye2011/r/ebyu/17449
Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid
Altun, D.; Uysal, H.; Ayar, A.; Aşkın, H.
In this study, the effects of chlormadinon acetate (CMA) and CMA + nordihydroguaiaretic acid (NDGA) on various developmental stages of Drosophila melanogaster were investigated. Different concentrations of CMA (1.0; 3.0; 5.0 and 10.0 μM/100 mL medium) and CMA + NDGA as the concentrations of CMA (1.0 + 1.0; 3.0 + 3.0; 5.0 + 5.0 and 10.0 + 10.0 μM/100 mL medium) were carried out during the developmental periods of the flies. When F1progeny of control and application groups were compared, CMA was found to extend the process of metamorphosis and decrease the total offspring numbers. However, these negative effects were inhibited by NDGA treatment at different concentrations. These results suggest that NDGA could effectively inhibit CMA-induced abnormalities in developmental stages of D. melanogaster. It was found that the difference between the groups was significantly important (p < 0.05).
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ArticleYalnız künye2011/r/ebyu/17448
Healthy lifestyle behaviour in university students and influential factors in eastern Turkey
Hacihasanoǧlu, Rabia; Yildirim, Arzu; Karakurt, Papatya; Saǧlam, Rabia
Hacihasanoǧlu R, Yildiri{dotless}m A, Karakurt P, Saǧlam R. International Journal of Nursing Practice 2011; 17: 43-51 Healthy lifestyle behaviour in university students and influential factors in eastern Turkey This research was carried out to determine the healthy lifestyle behaviour of university students receiving education in central Erzincan. The population of this descriptive and cross-sectional research included a total of 4506 students receiving education at Erzincan University in the city centre, and the sampling included 981 students selected by a simple random sampling method from these schools. Data were collected between April and May 2008 by using an identification form and the Health Promotion Life-Style Profile (HPLP) Scale. Healthy lifestyle behaviour point averages of students were detected to be at medium level (118.41±20.90). It was established that student's grade, educational level of parents, economic status of the family and the student, the place where the student stays and smoking status of the student resulted in a significant difference in HPLP Scale total score average and the mean score of the majority of subscales.
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ArticleAçık Erişim2011/r/ebyu/17330
Antioxidant and antimicrobial activity of Turkish endemic Sonchus erzincanicus extracts; [Türkiyede yetişen endemik Sonchus erzincanicus'un ekstraktlarının antioksidan ve antimikrobiyal aktiviteleri]
Mavi, Ahmet; Yiǧit, Nimet; Yiǧit, Demet; Kandemir, Ali
Sonchus erzincanicus (Asteraceae) is a plant species that is endemic to Turkey and grows in Erzincan. Lipid peroxidation inhibition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and total phenolic content of the methanol and water extracts of the plant were determined. Antimicrobial activity of the extracts was also tested against 107 clinical isolates of human pathogenic microorganism strains belonging to Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans using the disc-diffusion method, and the minimal inhibition concentration (MIC) value of each active extract was determined. The extracts were observed to have antioxidant potential, although no better than that of BHT (butylated hydroxytoluene), which is a wellknown commercial antioxidant. The extracts exhibited antimicrobial effects on all the tested microorganism species, except for P. aeruginosa and E. aerogenes. In addition, antifungal activity of the methanol extract against C. albicans was better than that of the water extract (inhibition zone: 25 mm; MIC: 0.156 mg/mL). As a consequence, it was observed that the methanol and water extracts of Sonchus erzincanicus had in vitro lipid peroxidation inhibition and antimicrobial effects against some microorganisms.
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ArticleAçık Erişim2011/r/ebyu/17252
Diet-induced obesity suppresses ghrelin in rat gastrointestinal tract and serum
Sahin, Ibrahim; Aydin, Suleyman; Ozkan, Yusuf; Dagli, Adile Ferda; Akin, Kadir Okhan; Guzel, Saadet Pilten; Catak, Zekiye; Ozercan, Mehmet Resat
The aims of the present study were to examine ghrelin expression in serum and gastrointestinal tract (GIT) tissues, and to measure tissue ghrelin levels and obesity-related alterations in some serum biochemical variables in rats with diet-induced obesity (DIO). The study included 12 male rats, 60 days old. The rats were randomly allocated to two groups (n = 6). Rats in the DIO group were fed a cafeteria-style diet to induce obesity, while those in the control group were fed on standard rat pellets. After a 12 week diet program including an adaptation period all rats were decapitated, tissues were individually fixed, ghrelin expression was examined by immunohistochemistry, and tissue and serum ghrelin levels were measured by radioimmunoassay. Serum biochemical variables were measured using an autoanalyzer. When the baseline and week 12 body mass index and GIT ghrelin expression were compared between DIO and control rats, BMI had increased and ghrelin expression decreased due to obesity. The RIA results were consistent with these findings. Serum glucose, LDL cholesterol, and total cholesterol levels were elevated and HDL cholesterol significantly decreased in the DIO group. A comparison of GIT tissues between the control and obese groups demonstrated that ghrelin was decreased in all tissues of the latter. This decrease was brought about a decline in the circulating ghrelin pool. This suggests that rather than being associated with a change in a single tissue, obesity is a pathological condition in which ghrelin expression is changed in all tissues.
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ArticleYalnız künye2011/r/ebyu/17194
The effect of patient education and home monitoring on medication compliance, hypertension management, healthy lifestyle behaviours and BMI in a primary health care setting
Hacihasanoǧlu, Rabia; Gözüm, Sebahat
Aims: The aim of this study was to determine the effect of anti-hypertensive patient-oriented education and in-home monitoring for medication adherence and management of hypertension in a primary care setting, by providing education on healthy lifestyle behaviours and medication adherence. Background: Hypertension is the third most common cause of death worldwide. Prevalence of hypertension in Turkey is approximately 30% in the general population and 45-50% in population over 50. Design: Randomised controlled study. Methods: This study conducted in Turkey used a study group comprised of 120 subjects (40 Group A, 40 Group B, 40 controls), all previously diagnosed with hypertension and who started medication therapy at least oneyear prior to start of study. The study was conducted between February-November 2006 at public primary health care facilities and homes of the study participants. Participants in Group A and B received a total of six monthly education sessions, four times during clinic visits and two home visits. Medication adherence education for Groups A and B and education about healthy lifestyle behaviours for Group B were administered in a structured and individualised format. The control group was routinely monitored in health care facilities. Results: Healthy lifestyle behaviours and perception of self-efficacy regarding medication adherence showed improvement after education sessions in Groups A and B. Systolic and diastolic blood pressures of subjects in Group A and B showed a significant decrease compared with those of the control group; the blood pressure decrease in Group B was greater than in Group A. Conclusion. Nurses play an important role in uncontrolled hypertension detection and can improve medication adherence and healthy lifestyle behaviours. Relevance to clinical practice. Patient education medication adherence alone and in combination with healthy lifestyle behaviour teaching is an effective tool for blood pressure reduction in the hypertensive population in primary health care settings.
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LetterAçık Erişim2011/r/ebyu/17192
To what extent is it right to measure serum vaspin, obestatin, and apelin-36 levels without a protease inhibitor in nonalcoholic fatty liver disease?
Aydin, Suleyman; Sahin, Ibrahim; Demirel, Ulvi; Aksoy, Aziz
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ArticleAçık Erişim2011/r/ebyu/17064
Investigation of the protective effects of vitamin C, Iron and desferrioxamine on heat stress resistance in the model organism Caenorhabditis elegans
Kiliçgün, Hasan; Olgun, Abdullah; Köksal, Zeynep
The aim of this study was to determine the effects of Vitamin C (Vit. C), iron, the iron chelating agent desferrioxamine (DF) and their most effective dose combinations on thermotolerance of Caenorhabditis elegans (C. elegans). Due to the fact that studies on aging and lifespan take long time, thermotolerance was used as a first step analysis for using the time more effectively. The data of this study showed that when compared with the control group, the use of vitamin C, DF and iron alone or their combinations were associated with an increase in the survival of C. elegans under heat shock. However, the treatment with DF and its combinations resulted in a survival rate significantly higher than the other combinations. The results of our study suggested that under conditions of heat stress, treatment of DF has the most significant beneficial effect on survival of C. elegans, suggesting some possible pleiotropic mechanisms other than iron chelation.
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ArticleYalnız künye2011/r/ebyu/17040
Determination of the effects of genistein on the longevity of Drosophila melanogaster Meigen (Diptera; Drosophilidae)
Altun, Deniz; Uysal, Handan; AşkIn, Hakan; Ayar, Arif
In this study, the effects of genistein on the longevity of Drosophila melanogaster were investigated. The effects of different concentrations of genistein (1, 3, 5 and 10 μM/100 mL medium) were separately administered one by one to female and male populations of D. melanogaster for application groups. In the control group, the maximum life span was determined to be 57 days for ♀♀, 46 for ♂♂. The maximum life span for the lowest (1.0 μL) and highest (10.0 μL) application groups among the adult populations of D. melanogaster subjected to genistein were observed to be 54, 50, 40 and 36 days for ♀♀ and 51, 48, 40 and 33 days for ♂♂. These values indicate a negative correlation (R = 0.513 for ♂♂ and R = 0.509 for ♀♀) between the maximum life span of the application groups and changing genistein concentrations.
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ArticleAçık Erişim2010/r/ebyu/18798
Effects of oral supplementation of mint extract on muscle pain and blood lactate
Sönmez, Gul Tiryaki; Çolak, Mergul; Sönmez, Sedat; Schoenfeld, Brad
Study aim: To determine the effects of mint extract on muscle pain and blood lactate levels after a 400-m run. Material and methods: A group of 16 physical education students (mean age 21.81 +/- 2.13 years) volunteered to participate in the study. The subjects were randomly assigned into 3 groups: mint, placebo or control. The mint group was given orally mint extract (5 ml/kg of body mass) and the placebo group was given unsweetened tea (5 ml/kg) in a double-blind fashion and cross-over design one hour before a 400-m running test. Subjects in the control group remained untreated. The effect of mint extract on muscle pain was recorded by an inquiry; blood lactate levels were measured after the running test. Results: Oral administration of mint extract significantly (p<0.01) decreased blood lactate concentrations but muscle pain levels remained unchanged in all groups. Conclusions: Oral administration of mint extract may have a beneficial effect on blood lactate clearance and therefore may increase athletic performance.
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Conference ObjectYalnız künye2010/r/ebyu/17821
Indoor and outdoor gamma dose measurements for specific counties of Trabzon-Turkey
Kurnaz, Asli; Küçükömeroǧlu, B.; Okumuşoǧlu, N.T.; Yeşilbaǧ, Y.Ö.; Angelopoulos, A; Fildisis, T
In this study, it was determined environmental gamma radiation dose rate for some counties of Trabzon-Turkey. A detailed ambient gamma dose measurement has been performed in the seven counties of Trabzon, using a portable environmental survey meter (NaI detector, INSPECTOR 1000). The measurements were performed indoor and outdoor of buildings and also at each spot, a reading was taken at 1 m above ground level. The dose rates varied from 42.69 nGy/h and 140.91 nGy/h for indoor gamma dose and 27.84 nGy/h and 121.80 nGy/h for outdoor gamma dose. Average indoor and outdoor gamma dose rates were ascertained to be 71.05 nGy/h and 60.20 nGy/h, respectively. The annual effective doses were calculated from indoor and outdoor gamma doses to be 348.56 μSv/y and 73.83 μSv/y, respectively.
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Conference ObjectAçık Erişim2010/r/ebyu/17793
The effect of perceived social support on subjective well-being
Gülaçti, Fikret; Uzunboylu, H
The aim of this study is to determine whether perceived social support is a meaningful predictor of subjective well-being. 87 students registered to primary classroom teacher training department joined to this survey. In the phase of data collection, "Subjective Well-Being Scale" and "Multi-Dimensional Perceived Social Support Scale" were used. It was discovered that perceived social support predicted 43 per cent of subjective well-being. In addition to this, it was determined that perceived family support predicted subjective well-being, and on the other hand the support which was perceived towards a special person and perceived friend support did not predicted subjective well-being.
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ArticleYalnız künye2010/r/ebyu/17783
Antimicrobial and antioxidant activity and chemical composition of the essential oil of tanacetum macrophyllum (Waldst. et Kit.) Schultz. Bip.
Javidnia, K.; Gholami, M.; Firuzi, O.; Özer, H.; Kandemir, A.
The essential oil of Tanacetum macrophyllum growing wild in Turkey was obtained by hydrodistillation, and antimicrobial activity of the essential oil was tested against six bacteria and two yeasts including Candida albicans and Aspergillus niger by disc diffusion method. Further the oil of this plant was analyzed by GC and GC/MS technique. Best effect of the oil was against pseudomonas earuginosa. Twenty-eight components, representing 95.6% of the total oil, were identified. The main component of the oil was β-eudesmol (89.5%). The antioxidant activity of the essential oil was measured by the ferric reducing antioxidant power (FRAP) assay.
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ArticleAçık Erişim2010/r/ebyu/17723
A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies
Alp, Cemalettin; Ekinci, Deniz; Gültekin, Mehmet Serdar; Şentürk, Murat; Şahin, Ertan; Küfrevioǧlu, Ömer Irfan
Here we propose a novel one-pot synthesis of new tosyl-pyrrole derivatives. By means of the new developed method, pyrrole derivatives were synthesized at room temperature in a single step, and a useful method is proposed for the synthesis of similar compounds. Moreover, inhibitions of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II by 1-tosyl-pyrrole and 1-tosyl-pyrrol-2-on derivatives were investigated. 1-Tosyl-pyrrole, 1-tosyl-1H-pyrrol-2(5H)-one, 5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one and 5-oxo-1-tosyl-2,5-dihydro-1H-pyrrol-2-yl acetate showed inhibitory action with Ki values in the range of 14.6-42.4 μM for hCA I and 0.53-37.5 μM for hCA II, respectively. All pyrrole derivatives were competitive inhibitors with 4-nitrophenylacetate as substrate. Some new synthesized pyrrole derivatives showed very effective hCA II inhibitory effects, in the same range as the clinically used sulfonamide acetazolamide, and might be used as leads for generating enzyme inhibitors targeting other CA isoforms.
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ArticleAçık Erişim2010/r/ebyu/17680
Correlation between antioxidant effect mechanisms and polyphenol content of Rosa canina
Kilicgun, Hasan; Altiner, Dehen
Rosa canina L. is a member of Rosaceae family, which is well-known for its high phenolic contents. These compounds are known to possess antioxidant, antimutagenic and anticarcinogenic effects. However, they have yet to pass controlled clinical trials for efficacy, and their potential for prooxidant activity is an understudied field of research. In order to estimate the correlations between phenolic contents and antioxidant/proxidant effect mechanisms, different concentrations of R. canina fruit extracts were examined in this study. R. canina showed antioxidant activities at all concentrations with respect to the reducing power, hydrogen peroxide scavenging activity and superoxide anion radical scavenging (O2-) activity assays, whereas a negative correlation was observed with the metal ion chelating activity and free radical scavenging activity [1,1-diphenyl-2-picryl-hydrazil (DPPH) % inhibition] assays at higher concentrations with the phenolic content of R. canina. These results suggest that R. canina may act not only as an antioxidant, but also as a prooxidant with the effects depending on its concentrations.
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ArticleAçık Erişim2010/r/ebyu/17664
Ghrelin, nitrite and paraoxonase/arylesterase concentrations in cement plant workers
Aydin, Suleyman; Aydin, Suna; Croteau, Gerry A.; Sahin, Íbrahim; Citil, Cihan
Occupational cement dust exposure has been associated with an increased risk of liver abnormalities, pulmonary disorders, and carcinogenesis. Decreased antioxidant capacity and increased plasma lipid peroxidation have been posed as possible causal mechanisms of disease. Accordingly, this study examined the serum paraoxonase (PON1) arylesterase (AE), ghrelin, HDL-C, LDL-C and serum nitrite (NOx) levels in cement dust exposed workers. Twenty-eight volunteer male cement plant workers and 30 volunteer control male workers, aged 29-54 years, participated. The concentrations of serum PON1, AE, NOx, ghrelin, and HDL-cholesterol and LDL-cholesterol were measured in both groups. PON-1, AE, ghrelin and HDL-cholesterol were lower in the cement plant workers than in controls. Serum nitrite (NOx), and LDL-C levels in cement plant workers were higher (p<0.05) than in the control group workers. No correlation was observed between the serum levels of HDL-cholesterol and PON1 and between HDL-cholesterol and ghrelin. A weak negative correlation was detected between the serum ghrelin and NOx. The study results strongly suggest that HDL-paraoxonase, AE, ghrelin, HDL-C, and high NOx, and LDL-C levels may have a role in disease involving oxidative damage. However, some studies are necessary to address the association between occupational dust exposure and respiratory symptoms.
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ArticleAçık Erişim2010/r/ebyu/17608
Extended longevity of Drosophila melanogaster by water and ethanol extracts of Stachys lavandulifolia
Altun, Deniz; Ayar, Arif; Uysal, Handan; Kara, Aye Aydan; Nal, Elif Leman
Context:Stachyss species have been used as a medicine for centuries throughout the world. Stachys lavandulifolia Vahl. var. lavandulifolia (Lamiaceae) is of interest to researchers because the constituents such as betulinic acid, oleanolic acid, rosmarinic acid, and ursolic acid are similar to other Stachys species commonly used as an alterative in medicinal preparations. Objective:The present study investigated the effects of water extract (SLE w) and ethanol extract (SLEe) obtained from S. lavandulifolia (SLE) on the longevity of Drosophila melanogaster Meigen. Materials and methods:The effects of different concentrations of SLE (ControlDMSO; 4.0; 12.0 and 20.0 μL/100mL medium) were administered separately to female and male populations of D. melanogaster for control and SLE groups. Results:In all application groups, each population's longevity increased, depending on the concentration of SLE. The mean life-span of the extract groups which are applied with SLE(w) was determined to be shorter than the extract groups which are applied with SLE(e). For example, the maximum mean life-span applied with SLE(w) increased from 31.86±0.92 days to 43.21±1.33 days and the maximum mean life-span applied with SLE(e) increased from 31.86±0.92 days to 49.62±1.62 days in females. Conclusion:These findings demonstrate that the constituents of S. lavandulifolia have great potential as a source for natural health products for D. melanogaster management.
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Conference ObjectAçık Erişim2010/r/ebyu/17572
Measurement of secondary school student's test-anxiety levels and investigation of their causes
Gürses, Ahmet; Kaya, Özgür; Doǧar, Çetin; Günes, Kübra; Yolcu, H. Hasan; Keser, H; Ozcinar, Z; Kanbul, S
Test anxiety is concerned about a large portion of our society (students, family environment). The portion affected from the test anxiety is increasing year by year. Test anxiety is not related with studying or studying much. The idea that studying much and getting new knowledge cause anxiety and stress is common. A student being tired by studying much can rest after a brief relaxation and exercise. What creates the anxiety is the fear of being unsuccessful and the thought that is the end of some values because of the failure. Determination of students' test anxiety is very important for the success in applied teaching activities. In this study intending to determine secondary school students' test anxiety, test anxiety scale and data collected from interviews were evaluated from the view of gender, class grades and enrolled educational institutions. After the analyses gained by descriptive statistical techniques and One-Way ANOVA, it was found that the students had mid-level test anxiety, and girls had higher test anxiety level than boys.
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ArticleYalnız künye2009/r/ebyu/18773
An application of multinomial response models using bayesian approach
Cengiz, Mehmet Ali; Terzi, Yuksel; Savas, Nurettin
This study focuses on a specific case of Generalized Linear Models for multinomial responses and investigates their analysis using Bayesian methods. The important problem of surgical planning for arterial occlusive disease is considered in some detail, as a medical application of these models. The study investigates the potential benefits which accrue when these ideas are applied to the important medical problem of locating and assessing the severity of lower-limb arterial occlusive disease.
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ArticleYalnız künye2009/r/ebyu/17812
Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms
Çetin, Bülent; Özer, Hakan; Çakir, Ahmet; Mete, Ebru; Tosun, Murat; Öztürk, Erdoǧan; Polat, Taşkin; Kandemir, Ali
The oil obtained by hydrodistillation from the aerial parts of Artemisia incana (L.) DRUCE from Turkey was analyzed by GC and GC/MS. Sixty-three compounds were characterized, representing 97.2% of the total components detected, and camphor (19.0%), borneol (18.9%), 1,8-cineole (14.5%), bornyl acetate (7.8%), camphene (4.9%), and α-thujone (4.8%) were identified as predominant components. The essential oil was also tested for its antimicrobial activity against 44 different foodborne microorganisms, including 26 bacteria, 15 fungi, and 3 yeast species. The essential oil of A. incana exhibited considerable inhibitory effects against all bacteria, fungi, and yeast species tested. However, the oil showed lower inhibitory activity against the tested bacteria than the reference antibiotics.
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ArticleYalnız künye2009/r/ebyu/17807
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV
Abdülkadir Coban, T.; Beydemir, Şükrü; Gücin, Ilhami; Ekinci, Deniz; Innocenti, Alessio; Vullo, Daniela; Supuran, Claudiu T.
Sildenafil citrate, a phosphodiesterase-5 (PDE5) inhibitor widely used for the treatment of erectile dysfunction was investigated for its interaction with the zinc-enzyme carbonic anhydrase (CA, EC 4.2.1.1), as it has in its molecule a piperazine moiety also found in some CA activators (CAAs). Sildenafil was a potent, low micromolar activator of several CA isozymes, such as CA I, VA and VI (KAs in the range of 1.08-6.54 μM), and activated slightly less the isoforms CA III, IV and VA (KAs of 13.4-16.8 μM). CA isozymes II, IX, XIII and XIV showed activation constants in the range of 27.5-34.0 μM, whereas the least activated isoforms were CA VII and XII (KAs of 72.9-73.0 μM). Sildenafil citrate was also given orally to Sprague-Dawley rats at 1 mg/kg body weight. Red blood cell CA activity was inhibited in the treated animals at 3-5 h post-administration (in the range of 60-85%), probably due to NO/nitrite formed by PDE5 inhibition or by another, unknown mechanism. Whether CA activation by sildenafil has clinical consequences in humans is beyond the scope of the present work and warrants further studies.
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