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- Suleyman, Halis(167)
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Yayınlar
- ArticleAçık Erişim2026Synthesis and Biological Evaluation of New Thiocarbamoylpyrazoline and Chalcone Derivatives on Bone Cancer Cell Lines: In Vitro and In Silico Studies
Demir, Fatma; Kahriman, Nuran; Aydın, Ali; Türkmenoğlu, Burçin; Mandal, Emre; Emirdağ, Safiye
In the pursuit of multifunctional therapeutic agents, a new series of thiocarbamoylpyrazoline derivatives were synthesized starting from chalcones, and all synthesized compounds (1–12) were structurally characterized using spectroscopic methods (NMR, FT-IR, and Q-TOF-LC-MS) and elemental analysis. The anticancer properties of the test compounds were evaluated in vitro against human bone cancer cell lines MG63 and SW1353 using MTT and LDH assays. LDH assay results demonstrated that the compounds exhibited no detectable cytotoxicity toward normal human chondrocyte (HC) cells. Compared to the reference drug 5-fluorouracil (5-FU), several compounds displayed notable antiproliferative activity. Tumor selectivity index (TSI) analysis identified compounds 1, 2, 4, and 10 as having high tumor selectivity, indicating a preferential cytotoxic effect toward cancer cells over normal cells. Among these, compounds 4 and 10 exhibited the most favorable anticancer profiles, combining potent antiproliferative activity with minimal toxicity to normal cells. Furthermore, to support the experimental anticancer findings, in silico molecular docking studies were performed using the crystal structures of caspase-3 (1GFW), human metalloproteinase-13 (3KEJ), human estrogen receptor (3ERT), and EGFR (1M17) against compounds 1, 2, 4, and 10, and their binding modes were analyzed.
- ArticleYalnız künye2026Emotional and psychological drivers of compulsive shopping: a qualitative exploration of triggers and coping mechanisms
Akın, Mustafa Seref
Background: Compulsive shopping is often driven by emotional and psychological factors that create a cyclical pattern of temporary relief followed by dissatisfaction. Emotional triggers such as sadness, loneliness, grief, frustration, anger, and nostalgia, as well as relational failures, unmet desires, and attempts to recapture a past identity, are believed to play a significant role in the development and persistence of compulsive shopping behaviors. Method: This study employed a qualitative research design, using in-depth interviews with participants who identified as compulsive shoppers. The interviews explored emotional and psychological triggers, the cyclical nature of compulsive buying behaviors, and coping mechanisms employed to manage these tendencies. Themes and patterns in participants’ narratives were analyzed to identify emotional drivers and potential strategies for intervention. Results: Participants reported using shopping as a temporary escape from emotional pain, such as sadness, loneliness, or grief, which often provided fleeting relief but was quickly followed by regret and dissatisfaction. Emotional dissatisfaction resulting from unmet shopping expectations, relational breakdowns, and attempts to preserve a past identity further perpetuated compulsive shopping cycles. Identified coping strategies included setting financial boundaries, engaging in therapy, building social connections, and practicing mindful consumption, which provided avenues for managing emotional triggers and reducing compulsive buying behaviors. Conclusion: This study underscores the significant role of emotional and psychological factors in compulsive shopping behaviors and highlights the cyclical nature of emotional triggers and dissatisfaction that sustains these patterns.
- ArticleAçık Erişim2026Positive and Negative Attitudes Toward Artificial Intelligence and E-Healthy Diet Literacy Among Adults: A Partial Least Squares Structural Equation Modeling Study
Özenir, Çiler; Altınsoy, Canan; Çubuk, Mihrican; Kılınç, Fatma Nişancı; Çakır, Biriz
Background/Objectives: This study aimed to examine the association between e-healthy diet literacy (e-HDL) and general attitudes toward artificial intelligence (AI) among adults. Methods: This cross-sectional study included 610 adults aged 19–64 years. Data were collected through face-to-face interviews using a questionnaire consisting of five sections, including sociodemographic characteristics, digital nutrition information practices, AI use in nutrition and dietetics, the e-Healthy Diet Literacy Questionnaire (e-HDLQ), and the General Attitudes toward Artificial Intelligence Scale (GAAIS). Descriptive statistics, validity and reliability analyses, correlation analyses, and Partial Least Squares Structural Equation Modeling (PLS-SEM) were performed. Statistical significance was accepted at p < 0.05. Results: The mean age of the participants was 33.07 ± 11.36 years, and 50.8% were female. The measurement model demonstrated acceptable reliability and convergent validity. Structural model analysis showed that positive attitudes toward AI were positively associated with e-HDL (β = 0.243, p < 0.001), whereas negative attitudes toward AI were negatively associated with e-HDL (β = −0.232, p < 0.001). Among the e-HDLQ dimensions, the strongest loading was observed for finding e-healthy diet information (β = 0.844), followed by applying e-healthy diet information (β = 0.641), digital healthy eating literacy (β = 0.636), judging e-healthy diet information (β = 0.308), and understanding e-healthy diet information (β = 0.277). Together, positive and negative attitudes toward AI explained 12.2% of the variance in e-HDL (R2 = 0.122), indicating a modest explanatory contribution. Conclusions: Positive and negative attitudes toward AI were independently associated with e-HDL among adults. Although the explained variance was modest, AI attitudes may represent one of several factors associated with digital nutrition literacy, warranting further investigation in future studies.
- ArticleAçık Erişim2026Biomechanical Behavior of Endodontically Treated Abutment Teeth with Periapical Lesions: A 3D Finite Element Analysis
Klrmall, Ömer; Zeynalll, Ayten; Akar, Türker; Celik, Huseyin Kursat
Objectives The stress distribution of teeth with periapical lesions, which are used as abutments in fixed prostheses, and its effect on the success of the restoration are not well known. This study investigates stress distribution in abutment teeth with periapical lesions and surrounding tissues under occlusal load using finite element analysis. Materials and Methods Three models were constructed: (1) a healthy mandibular premolar, (2) a premolar with a periapical lesion restored using a fiber post and single crown, and (3) a similar premolar used as an abutment for a three-unit bridge. A static load of 300 N was applied at a 45-degree angle to the tooth's long axis, targeting the lingual slope of the buccal cusp. Stress and deformation were analyzed across all structural components, including dental tissues and the surrounding trabecular bone. Results The results demonstrated that, in model 2, stress propagation extended more prominently along the root surface and progressed apically, resulting in a higher stress concentration in the periapical lesion region (0.061 MPa) when compared with model 3 (0.054 MPa). Furthermore, the greatest deformation was also observed in model 2. Across all models, peak stress was consistently localized in the cervicobuccal collar region of the tooth. Conclusion These findings underline the importance of prosthesis design in reducing the stress concentration in abutment teeth with periapical lesions and demonstrate the biomechanical advantage of splinted restorations over single crowns in cases with periapical lesions.
- ArticleYalnız künye2026Social media exposure by content type and orthorexia nervosa tendencies: multivariable and sex-stratified analyses in adults
Baspinar, Busra
Orthorexia nervosa (ON), characterized by a pathological preoccupation with dietary purity, has been increasingly linked to social media use. This cross-sectional study examined associations between four social media content categories—self-optimization and health, appearance and social comparison, entertainment, and informational and hobby content—and ON tendencies in adults (n = 2,435), using multivariable linear regression and sex-stratified analyses with the ORTO-11. Participants classified as having elevated ON tendency according to the sample-derived threshold (n = 586) were older, more likely to be female, and more highly educated; BMI did not differ between groups. In the fully adjusted model (R²=0.042), self-optimization and health content was the strongest correlate of lower Orto-11 scores (β=−0.45, 95%CI − 0.62 to − 0.28, p < 0.001). Informational and hobby content was also significantly associated with lower scores (β=−0.38, 95%CI − 0.67 to − 0.08, p = 0.013). Appearance-oriented and entertainment content were not independently associated with ON tendencies after adjustment. Sex-stratified analyses showed that the association with self-optimization content was consistent across sexes (males: β=−0.45, p = 0.01; females: β=−0.48, p < 0.001), with no significant sex × content interaction. Effect sizes were negligible (Cliff’s delta:0.006–0.125) and the model explained only 4% of variance, indicating limited practical magnitude. Given the cross-sectional design, causal inference is precluded and reverse causation cannot be excluded. These findings suggest that content type may be more informative than usage duration in characterizing the social media–ON relationship, with health-optimization content emerging as a modest but consistent correlate of ON tendencies across sexes.
- ArticleYalnız künye2026Evaluation of the protective effects of different antioxidants against the toxicity of herpes simplex virus 1 glycoprotein D
Işik, Gözde; Çakir, Deniz Arca; Yirün, Anil; Erdemli-Köse, Selinay Başak; Özçelik, İbrahim; Erkekoǧlu, Pinar
Herpes simplex virus type 1 (HSV-1) infects an estimated 3.8 billion people under age 50 worldwide and establishes lifelong neuronal latency, leading to recurrent disease manifestations such as neonatal and genital herpes; yet no vaccine or curative therapy exists. This study evaluated the oxidative-stress-modulating effects of HSV-1 glycoprotein D (gD) alone or in combination with two antioxidant agents - ascorbic acid and sodium selenite - in a human neuroblastoma cell line. Key oxidative-stress markers - including total glutathione (GSH), malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), 8-isoprostane and protein carbonyl content - were quantified following exposure to "gD,""gD plus ascorbic acid", or "gD plus sodium selenite". Additionally, molecular docking analyses compared the binding affinities of ascorbic acid and sodium selenite for gD. Results showed that co-administration of ascorbic acid or sodium selenite with gD significantly elevated reactive oxygen species (ROS) levels compared to gD, while GSH and protein carbonyl concentrations remained unchanged. Intermediate lipid-peroxidation products did not differ significantly across treatment groups. Docking studies suggested that ascorbic acid exhibits a stronger potential for biologically relevant interaction with gD than sodium selenite, indicating a more pronounced antioxidant effect. These findings underscore the complexity of gD-induced oxidative pathways and highlight the need for further in vitro and in vivo investigations to delineate the toxicological impact of HSV-1 gD, as well as to extend analysis to other viral proteins involved in oxidative stress.
- ArticleAçık Erişim2026Angiotensin 1–7 Modulates the Dynamics and Activation of the Proto-Oncogene Mas Receptor
Yasar, Ekrem; Dogru, Segun; Eroglu, Erol; Yaras, Nazmi
The proto-oncogene Mas receptor (MasR) is a class-A (orphan-type) G protein-coupled receptor (GPCR) that mediates the cardioprotective effects of Angiotensin 1–7 (Ang 1–7) within the renin–angiotensin system (RAS). Despite its therapeutic relevance, the molecular mechanisms underlying MasR activation remain elusive due to the lack of experimental structural data. In this study, we combined 1-μs all-atom molecular dynamics (MD) simulations of AlphaFold-modeled MasR with energetic network analyses to elucidate ligand-induced activation dynamics. Our results challenge the conventional electrostatic clamp model, revealing a distinct active anchor mechanism. We demonstrate that Ang 1–7 releases the inactive core lock (ARG245–TYR248) to engage a critical anchor cluster (SER109/PHE112). This interaction stabilizes a unique decoupled conformational state: while the NPxxY motif is fully activated and the intracellular vestibule expands via noncanonical communication hubs that substitute for the absent conserved microswitches, TM6 remains in a restricted, compact conformation (~10 Å). Thermodynamically, this partial activation is supported by favorable computed binding energetics and enhanced conformational plasticity. These findings provide a structural rationale for the partial agonist profile of Ang 1–7 and offer a transformative mechanistic framework for therapeutic targeting of the ACE2/Ang 1–7/MasR axis. We propose that rational drug design need not aim for maximal receptor opening; instead, strategies focusing on peptidomimetics or positive allosteric modulators (PAMs) that stabilize this specific compact active state could selectively potentiate protective RAS signaling.
- ArticleYalnız künye2026Assessment of cultural competence levels of healthcare professionals: a study in a university hospital with a health tourism authorisation certificate
Gedik, Özlem; Şimdi, Refika Ülke; Kara, Derya
This study aims to evaluate the cultural competence levels of healthcare professionals working in a university hospital authorised for health tourism, where patients from different cultures are concentrated. The research concluded that the cultural competence of healthcare professionals showed significant differences according to demographic characteristics, and characteristics related to cultural interest, curiosity, and experience. Cultural sensitivity had a partial mediating effect in the relationship between cultural knowledge and cultural skills. In the context of health tourism, possessing cultural knowledge alone is not sufficient for healthcare professionals to establish effective and trust-based communication with patients from different countries and cultural backgrounds. When this knowledge is combined with cultural sensitivity, it can be transformed into cultural skills, which in turn enhances patient satisfaction and improves the quality of healthcare services. It is crucial to re-evaluate global health service delivery with a knowledge-based approach to culture and to shape the understanding of solutions to existing or potential problems. In terms of achieving cultural competency, in-service training for staff could be a valuable recommendation for hospital management and contributing to the development of health tourism.
- ArticleAçık Erişim2026Smartphone Screen Time, Sleep Quality, and Headache in Young Adults Presenting to the Emergency Department: A Case–Control Study
Kantar, Yusuf; Aslan, Yusuf Ertuğrul; Eden, Arif Onur; Bilgin, Yasin; Tanrıverdi, Orhan; Yurttutan, Abdullah Emre; Çimen, Erdem Yakup; Sarı, Fatih Mehmet
Background: Smartphone screen exposure has increased substantially among young adults and has been associated with headache and sleep disturbances. This study aimed to investigate the associations between smartphone screen time, headache severity, sleep duration, and sleep quality in young adults presenting to the emergency department with headache. Methods: This single-center case–control study was conducted in the emergency department of a tertiary university hospital between November 2025 and April 2026. A total of 300 participants aged 18–40 years were enrolled, including 150 patients with headache and 150 controls without headache. Daily smartphone screen time was obtained from the built-in smartphone records for the preceding completed seven-day period, headache severity was assessed using the 11-point Numeric Rating Scale, and sleep quality was evaluated using the validated Turkish version of the Single-Item Sleep Quality Scale. Results: Participants with headache had longer smartphone screen time (7.0 vs. 5.0 h/day; p < 0.001), shorter sleep duration (7.0 vs. 8.0 h/day; p = 0.005), and poorer sleep quality (5.0 vs. 7.0; p < 0.001) than controls. Screen time correlated with headache severity (ρ = 0.430, p < 0.001) and inversely with sleep quality after adjustment for study group (partial ρ = −0.185, p = 0.001). Nonlinear multivariable modeling showed an association with headache presentation (p < 0.001); relative to 6 h/day, the aOR at 7 h/day was 8.83 (95% CI: 5.00–15.60), with a plateau at higher exposures. Conclusions: Longer device-recorded smartphone screen time was associated with headache presentation and severity in young adults. Participants with headache also reported poorer sleep quality and shorter sleep duration. These findings suggest relevant associations between smartphone exposure, sleep, and headache but do not establish causality or a clinical screen-time threshold. Prospective studies are warranted.
- ArticleAçık Erişim2026Protective Role of Chrysin against Mercury Chloride-Induced Testicular Damage via Oxidative Stress, Inflammation, Apoptosis, Endoplasmic Reticulum Stress, and Autophagy Pathways
Aygörmez, Serpil; Makav, Mustafa; Karadağ Sarı, Ebru; Dalkılınç, Elif; Uslu, Hamit; Maraşlı, Şaban
The aim of this research was to examine the potential ameliorative effects of chrysin (CHR) against mercuric chloride (HgCl2)-induced testicular damage in rats. For this purpose, rats were divided into four groups: Control, CHR, HgCl2 and HgCl2 + CHR. HgCl2 was administered intraperitoneally at a dose of 1.23 mg/kg, and CHR was administered orally at a dose of 50 mg/kg for 7 days. Biochemical, molecular and immunohistochemical analyses were performed to determine the effect of treatment-mediated changes in the testicular tissue. Based on the results obtained in testicular tissue, administration of HgCl2 was observed to lower antioxidant markers, elevate malondialdehyde (MDA) levels, and increase inflammatory marker expression in rat testicular tissue. It also led to reduced testosterone levels. Additionally, there was a decrease in the expression of antiapoptotic B-cell lymphoma 2 (Bcl-2) an apoptosis marker while the levels of Caspase-3 and Bcl-2-associated X protein (Bax) were found to be higher. The endoplasmic reticulum stress marker protein kinase R-like ER kinase (PERK) and the autophagy marker Beclin-1 showed strong immunoreactivity. Additionally, HgCl2 + CHR treatment were found to significantly reduce oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress and autophagy processes in testicular tissue. In conclusion, HgCl2 administration to rats caused testicular tissue damage compared to the other groups, but CHR treatment alleviated this damage. Overall, this demonstrates the potential ameliorative mechanisms of CHR as a possible agent for HgCl2-induced testicular damage.
- ArticleAçık Erişim2026Associations Between Complete Blood Count-Derived Inflammation Indices and Emergence Delirium in Children Undergoing Adenotonsillectomy
Altıparmak, Serkan; Kars, Ayhan; Salcan, Sara; Koç, Alparslan
Background: Emergence delirium (ED) is a common postoperative complication in the pediatric population. Although the pathophysiology of ED has not been fully elucidated, an association has been suggested between inflammation and the development of the condition. Aims: The aim of this study was to investigate the associations between the development of ED and preoperative inflammatory indices, primarily the systemic immune inflammation index (SII) and the pan-immune inflammation value (PIV) calculated from complete blood count parameters in pediatric patients undergoing adenoidectomy or adenotonsillectomy. Methods: This prospective study was conducted with children aged 3–12 years who underwent adenoidectomy or adenotonsillectomy at our hospital. Preoperative inflammatory indices were calculated from complete blood count parameters, including the SII (platelet × neutrophil/lymphocyte), PIV (platelet × neutrophil × monocyte/lymphocyte), neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and platelet-to-monocyte ratio (PMR). ED was assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale, while the Face, Legs, Activity, Cry, Consolability (FLACC) scale was used to minimize confounding by postoperative pain. Statistical analyses included receiver operating characteristic (ROC) curve analysis and multivariable logistic regression to assess the association between inflammatory indices and emergence delirium. Results: ED occurred in 32 out of 99 patients (32.3%). SII exhibited an AUC of 0.850 with a cut-off value of 412 (sensitivity 81.3%; specificity 86.6%). PIV exhibited an area under the curve of 0.883, with a cut-off value of 289 (sensitivity 75.0%; specificity 92.5%). In the univariable analysis, operative time, SII, and PIV were significantly associated with ED. In the multivariable analysis, operative time, SII and PIV were significantly associated with ED. Conclusions: SII and PIV values derived from routine complete blood count parameters were observed to be associated with the development of ED in pediatric patients undergoing adenotonsillectomy and may provide useful insights into the potential role of systemic inflammation in the pathophysiology of such delirium.
- ArticleAçık Erişim2026Positive future expectancy mediates the relationship between attitudes toward the future and future anxiety among Faculty of Sport Sciences students
Seçer, Emrah; Esentürk, Oğuz Kaan; Kabak, Serkan; Yarayan, Yunus Emre; Keskin, Kadir; Alkhamees, Nouf H.; Ibrahim, Zizi M.; Al-Mhanna, Sameer Badri; Batrakoulis, Alexios
Introduction and aim: This study was conducted to determine the mediating role of positive future expectations in the effect of future attitudes on future anxiety. Method: This study employed quantitative research methods and a survey model. The study group consisted of 269 university students enrolled in sports science faculties (160 male, 109 female). Data were collected using the Attitudes Toward Future Scale (ATF), Future Anxiety Scale in University Students (FAS), and the Positive Future Expectation Scale (PEF). During the analysis process, confirmatory factor analysis (CFA) was first conducted using the AMOS 21 program to validate the factor structure of the scales. To test the research hypotheses, correlation analysis was performed using the SPSS 25 program, and Bootstrap-based regression analysis was applied using the Process Macro add-on developed by Hayes (2022). Results: The study found statistically significant moderate correlations between ATF and FAS, between ATF and PEF, and between FAS and PEF. Bootstrap regression analysis revealed that ATF had a significant effect on PEF (β = 0.182; p <.001). When a mediator variable was added to the model, it was determined that ATF was not a predictor of FAS (b: 0.052; p >.050). When ATF was held constant, it was determined that PEF had a significant effect on FAS (-2.124, p<.001). Finally, it was determined that ATF had a significant indirect effect on FAS through PEF (-0.387; p<.001). Conclusion: The study found that the attitudes of sports science students toward the future affect their anxiety about the future, and that positive expectations for the future play an important role in reducing this anxiety.
- ArticleAçık Erişim2026Enjoyment as a motivational driver of sport continuation: a moderated mediation model of engagement and social support
Kaçay, Zülbiye; Seçer, Emrah; Yıldız, Nuh Osman; Esentürk, Oğuz Kaan; Talaghir, Laurentiu-Gabriel; Bentea, Cristina Corina; Ivan, Paula; Cristea, Florentina
Introduction and aim – The present study aimed to examine the effect of enjoyment of physical activities on intention to continue sport participation and to determine the mediating role of sport engagement and the moderating role of perceived social support in this relationship. Methods – This correlational study included 748 athletes (445 males, 303 females, M = 23.10, SD = 5.59). The Physical Activity Enjoyment Scale, Intention to Continue Sport Scale, Sport Engagement Scale, and Perceived Social Support Scale–Short Form were used as data collection instruments. The measurement model and construct validity of the scales were tested using confirmatory factor analysis (AMOS 21). Hypotheses were tested in SPSS 25 using PROCESS Macro models (4, 1, and 14). Results – To test the first hypothesis, the mediation effect was examined using PROCESS Model 4 (PACES → SES → ICSS). The indirect effect of PACES on ICSS via SES was found to be significant (b = 0.230, 95% CI [0.184, 0.279]). For the second hypothesis, PROCESS Model 1 was applied. The main effect of perceived social support (PSS) was not significant (b = 0.076, p > .05), whereas the interaction term representing the SES × PSS interaction was significant (b = −0.0147, 95% CI [−0.0245, −0.0049]), indicating that perceived social support moderated the relationship between sport engagement and intention to continue sport participation. To test the third hypothesis, a moderated mediation model (PROCESS Model 14) was conducted with PSS as a moderator. The index of moderated mediation was significant (b = −0.010, 95% CI [−0.020, −0.0005]), showing that perceived social support moderated the indirect effect of PACES on ICSS through SES. Conclusion – The findings revealed that the indirect effect of enjoyment of physical activities on intention to continue sport participation through sport engagement was stronger among athletes with lower perceived social support.
- ArticleYalnız künye2026Thin-slice 3D MR arthrographic analysis of capsular folds and fold-like structures in the superior shoulder joint
Ertogrul, Rodi; Ogul, Hayri; Yahsi, Yusuf; Sakci, Zakir; Ozdemir, Mustafa; Kantarci, Mecit; Levent, Akin
Background Superior capsular folds and fold-like structures in the glenohumeral joint are potential sources of superior shoulder POS=12ptpain. Purpose To obtain detailed information about the arthrographic anatomy and morphology of superior capsular folds and fold-like structures. Material and Methods This study followed a retrospective design and involved 300 consecutive shoulder magnetic resonance (MR) images and MR arthrograms in two centers. The origins and insertions of the superior capsular folds and fold-like structures in the glenohumeral joints were carefully examined and documented. Four subtypes of extensions in the sagittal-oblique plane of the posterior synovial fold were identified from the MR arthrograms, according to their associations with the biceps tendon long head, superior glenoid notch, and supraspinatus tendon. Further, two morphological subtypes of superior synovial folds were identified: cord-shaped and fan-shaped. Results Superior capsular folds and fold-like structures in the shoulder joint were identified in 11 (4%) patients. Of these 11 superior capsular folds, 6 (54.5%) were then confirmed upon arthroscopy. The cord-shaped type was the most common MR arthrographic superior synovial fold and was detected in 8/11 (72.7%) patients. Type B was the most common form according to the course and insertion of the superior capsular fold (4/11 [37%] patients). Conclusion Superior capsular folds, probably normal capsular anatomical variants, tend to be present in the posterior portions of the superior shoulder joint capsule and are rarely seen in MR arthrograms. These anatomical variations tend to be symptomatic, especially in young individuals.
- ArticleAçık Erişim2026Detorsion is not innocent: pirfenidone prevents contralateral ovarian damage following ovarian torsion
Halici, Hamza; Karakoy, Zeynep; Yurdgulu, Emir Enis; Ay, Yusuf Anil; Cadirci, Elif; Toktay, Erdem; Kavas, Betul
Ovarian torsion is a gynecological emergency caused by rotation of the vascular pedicle, leading to ischemia, necrosis, and potential fertility loss. Management remains controversial, particularly regarding oophorectomy versus ovarian preservation. Detorsed ovaries continue cytokine secretion, impairing contralateral ovarian function, and no protective therapy currently exists. This study aimed to compare oophorectomy and detorsion strategies and to determine whether post-detorsion long-term pirfenidone therapy preserves ovarian function, thereby providing experimental resolution to the clinically pivotal “save or sacrifice” dilemma. Forty female rats were divided into five groups: Healthy, IR, IR + OVX, IR + Pirfenidone 50 mg/kg, and IR + Pirfenidone 100 mg/kg. Ischemia was induced in the left ovary of IR groups; in IR + OVX, the ovary was excised at 3 h, while in other groups, ovaries were reperfused. Treatments continued for 30 days. Ovarian tissues and blood were analyzed histopathologically, biochemically, and molecularly. Ovarian ischemia–reperfusion induced a persistent inflammatory and profibrotic response not only in the ischemic ovary but also in the contralateral ovary, leading to reduced estrogen levels and marked histopathological damage. Importantly, detorsion alone did not prevent contralateral injury, whereas oophorectomy attenuated molecular alterations. Post-detorsion pirfenidone therapy dose-dependently restored estrogen production, suppressed inflammasome activation (IL-1β, NLRP3, caspase-1) and fibrotic signaling (SMAD2, SMAD3, TGF-β1), and preserved normal follicular architecture in both ovaries. These findings demonstrate that the detorsed ovary remains a biologically active source of injury and identify pirfenidone as a potential adjunct therapy capable of protecting ovarian function after torsion.
- ArticleAçık Erişim2026Diagnostic performance of clinical symptom combinations for Crimean-Congo hemorrhagic fever in emergency department patients with reported arthropod bites, stings, or exposure
Bilgin, Yasin; Sari, Fatih Mehmet; Sakal, Cemalettin; Cimen, Erdem Yakup; Tanrıverdi, Orhan; Yurttutan, Abdullah Emre; Binay, Umut Devrim
Background: Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal tick-borne viral disease that remains an important public health problem in endemic regions. Early recognition of CCHF in emergency departments is challenging because initial clinical manifestations are often nonspecific. This study aimed to evaluate the demographic, clinical, and exposure-related characteristics of adult patients presenting to the emergency department after reported or clinically suspected arthropod bites, stings, or contact and to investigate clinical predictors associated with CCHF. Methods: This retrospective single-center study included adult patients presenting to the emergency department after reported or clinically suspected arthropod bites, stings, or contact between October 1, 2023, and October 1, 2024. A total of 526 patients were screened; 24 patients with incomplete data and 2 patients younger than 18 years were excluded. Demographic characteristics, clinical symptoms, and history of tick exposure were recorded. Clinical findings associated with CCHF were analyzed using univariable and multivariable statistical methods. The diagnostic performance of symptom combinations with tick exposure was evaluated using sensitivity, specificity, predictive values, likelihood ratios, odds ratios, and relative risks. Results: A total of 500 adult patients were included, and CCHF was confirmed in 38 patients (7.6%). The mean age was 49.48 ± 15.91 years, and 62.8% of the patients were male. Fever, headache, diffuse body aches, malaise, nausea/vomiting, diarrhea, abdominal pain, rash, ecchymosis, and history of tick exposure were significantly more frequent in CCHF-positive patients (all p < 0.05). CCHF positivity was significantly higher among patients with a history of tick exposure than among those without tick exposure (11.9% vs 3.8%; OR: 3.45, p = 0.001). Among symptom combinations evaluated with tick exposure, diffuse body aches showed the highest specificity (100.0%) and a very high positive likelihood ratio after continuity correction; however, these estimates should be interpreted cautiously because no CCHF-negative patient had this combination. In multivariable logistic regression analysis, malaise (adjusted OR: 117.29, 95% CI: 28.23–487.33, p < 0.001) and fever (adjusted OR: 6.41, 95% CI: 1.87–21.94, p = 0.003) were independently associated with CCHF. Conclusion: Simple clinical findings and symptom combinations may provide valuable early diagnostic clues for CCHF in endemic regions, even before laboratory confirmation. In particular, malaise and diffuse body aches in patients with a history of tick exposure showed high diagnostic performance and may contribute to early recognition and appropriate management of CCHF in emergency department settings.
- ArticleYalnız künye2026The Relationship Between Attitudes Toward Sexuality During Pregnancy and Sexual Quality of Life
Kaloğlu Binici, Dilek; Köse Tuncer, Sevinç
Purpose: – This study aimed to examine the relationship between attitudes toward sexuality during pregnancy and sexual quality of life. Methods: – This descriptive and correlational study included 433 pregnant women who either visited the non-stress test unit of a public hospital between October 2021 and March 2022 or participated online via Google Forms, email, and WhatsApp between June and July 2022. Data were collected using 3 tools: the Pregnant Women’s Introductory Information Form, the Sexual Quality of Life-Female Scale, and the Attitude Toward Sexuality During Pregnancy Scale. Results: – Multiple linear regression analysis revealed that employment status, income level, receiving information about sexual life during pregnancy, satisfaction with sexual life before pregnancy, and satisfaction with sexual life during pregnancy significantly influenced sexual quality of life scores. Conclusions: – Pregnant women who hold positive beliefs and values about sexuality during pregnancy, experience less anxiety related to sexual activity, and who approve of sexuality during pregnancy tend to have higher sexual quality of life. Implications for Practice and Research: – Understanding the perceptions and concerns that contribute to negative attitudes toward sexuality during pregnancy, and providing individualized, evidence-based counseling can support the sexual well-being of pregnant women and their partners.
- ArticleAçık Erişim2026Rational design of pyrazole–oxime hybrids as dual-targeting agents for glioma and breast cancer brain metastasis
Gul, Merve; Alagoz, Mehmet Abdullah; Hepokur, Ceylan; Algul, Oztekin
To design, synthesize, and biologically evaluate a novel series of 1-(4-chlorophenyl)-2-(4-methylpyrazol-1-yl)ethenone oxime derivatives (5–15) as targeted anticancer agents, focusing on their selectivity for glioma, mechanistic action, and blood–brain barrier (BBB) permeability. The oxime derivatives were synthesized and characterized using 1H-NMR, 13C-NMR, and mass spectrometry. In vitro cytotoxicity was assessed against C6 (glioma), MCF-7 (breast cancer), and SH-SY5Y (human neuroblastoma) cell lines. Flow cytometry evaluated apoptosis and cell cycle arrest for the lead compound. Molecular docking simulations were performed against CDK6 (PDB: 5L2I) and P-glycoprotein/ABCB1 (PDB: 7A6E). All derivatives exhibited selective potency against C6 glioma cells. Compound 14 demonstrated the highest antiproliferative activity (IC₅₀: 31.23 µM) against tumor lines while sparing SH-SY5Y cells. Flow cytometry confirmed that compound 14 triggers apoptosis and induces cell cycle arrest in C6 cells. Molecular docking predicted the most favorable docking scores for compound 14 against both CDK6 and P-glycoprotein. Structure–activity relationships (SAR) analysis validates the 4-methylpyrazole core as a viable scaffold for targeted glioma therapy. These results suggest that further functionalization of the O-alkyl oxime moiety merits further investigation as a starting point for potentially brain-penetrant scaffolds, although in vivo and target-level validation are required.
- ArticleYalnız künye2026The serial mediation of job stress and work-family conflict in the relationship between compulsory citizenship behaviour and citizenship fatigue among healthcare workers
Özen, Şener; Yücel, İlhami
Purpose – This study aims to examine the sequential mediating roles of job stress (WS) and work-family conflict (WFC) in the relationship between compulsory citizenship behaviour (CCB) and citizenship fatigue (CF) among healthcare workers in Turkish public hospitals, grounded in Conservation of Resources (COR) theory and the job demands-resources (JD-R) model. Design/methodology/approach – A cross-sectional design was employed with 483 healthcare workers (67.7% female), including nurses, physicians, and administrative staff. Validated Turkish scales measured CCB, CF, WS and WFC. Data were analysed using correlation analysis, structural equation modelling (SEM) and Hayes' PROCESS macro (Model 6, 5, 000 bootstrap samples). Findings – CCB was positively associated with CF (β = 0.43, p < 0.001). Job stress and WFC sequentially mediated this relationship (total indirect effect β = 0.18, SE = 0.03, LLCI = 0.13 and ULCI = 0.25 95%). Results align with COR theory, demonstrating that CCB depletes resources, escalating stress and WFC, ultimately leading to CF. Originality/value – This study advances the literature by empirically testing a novel serial mediation model in healthcare, highlighting how CCB's effects extend beyond the workplace into family life. It underscores the need for organisational interventions to mitigate compulsory demands and support work-life balance.
- ArticleYalnız künye2026The Effect of Positive Childhood Experiences on Parenting Skills: A Study with Mothers of Primary School Children
Deleş, Bayram; Aral, Neriman
This study addresses a significant gap in understanding the impact of mothers' positive childhood experiences on their parenting skills. The study aims to fill this gap by examining the relationship between mothers' positive childhood experiences and parenting skills. A total of 490 mothers whose children attend private primary schools in various provinces of Türkiye participated in the study using a relational survey model. Data were collected using the ‘General Information Form,’ ‘Positive Childhood Experiences Scale’, and ‘Child Education Competence Scale.’ Statistical analyses were used for the Mann–Whitney U test, Kruskal–Wallis H test, and regression analysis. The findings revealed a significant relationship between mothers' childhood experiences and parenting skills, and mothers who experienced positive parent–child communication and grew up in rural areas had higher parenting skills. In addition, positive childhood experiences positively affected mothers' child education competencies. These results underline the importance of mothers' childhood experiences in shaping their parenting skills and highlight the need for intervention programs and comprehensive family education initiatives to improve parenting skills. This study aims to add valuable information to parenting education and family counseling and ultimately support the healthy development of children.
