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- Suleyman, Halis(167)
- Mammadov, Renad(95)
- Türkeş, Cüneyt(84)
- Aydin, Sonay(83)
- Altuner, Durdu(74)
- Suleyman, Bahadir(68)
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- Arslan, Yusuf Kemal(50)
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- Coban, Taha Abdulkadir(49)
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- Altay, Ahmet(46)
- Huyut, Mehmet Tahir(46)
- Aydin, Suleyman(45)
- Türkmenoğlu, Burçin(45)
- Kuzucu, Mehmet(40)
- Yazici, Gulce Naz(40)
- Peker, Kemal(39)
- Algul, Oztekin(38)
- Cicek, Betul(37)
- Mertoglu, Cuma(36)
- Camurcu, Yalkin(35)
- Suleyman, Zeynep(34)
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- Gunay, Murat(31)
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- Köksal, Ekrem(31)
- Yuca, Hafize(31)
- Dilek, Esra(30)
- Karakurt, Papatya(30)
- Ozcicek, Fatih(30)
- Süleyman, Halis(30)
- Onk, Didem(29)
- Ucpunar, Hanifi(29)
Yayınlar
- MakaleAçık Erişim2024C-terminal cross-linking telopeptide levels in COVID-19 patients: A prospective case-control study
Gul, Mehmet Ali; Kurt, Nezahat; Ozgeris, Fatma Betul; Yuce, Neslihan; Kocak, Omer Faruk; Parlak, Emine
Background. Coronavirus disease 19 (COVID-19) is a viral infection mediated by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). The disease may affect biochemical parameters and electrolytes. C-terminal cross-linking telopeptide (CTX-I) is released during mature bone resorption and is a biomarker for predicting bone resorption. Objectives. As the pandemic progressed, understanding the effects of COVID-19 disease remained critical. Inflammatory responses triggered by the virus can result in a bone metabolism regulation imbalance. As such, this study aimed to analyze serum levels of CTX-I, calcium (CA), phosphorus (P), magnesium (Mg), C-reactive protein (CRP), and alkaline phosphatase (ALP) in COVID-19 patients to investigate the relationship between bone resorption and the disease. Materials and methods. The study included 56 individuals with COVID-19 (divided into mild, moderate and severe subgroups depending on disease severity) and 25 healthy adults as a control group. Serum CTX-I concentrations were measured with enzyme-linked immunosorbent assay (ELISA). In addition, CRP, Ca, Mg, P, and ALP levels were measured using an automated clinical chemistry analyzer. Results. Serum CTX-I levels were significantly higher in COVID-19 patients than in the control group (p < 0.05). Furthermore, a positive weak relationship was detected between CRP and CTX-I (r = 0.303, p < 0.05). Conclusions. Increased serum CTX-I levels in the patient group caused COVID-19-driven bone degradation, though serum CTX-I levels did not differ according to disease severity.
- Derleme MakaleAçık Erişim2024Earthquakes from a radiological perspective: what is demanded from the radiologists, and what can we do? A pictorial review
Aydin, Sonay; Kazci, Omer; Ece, Bunyamin; Kantarci, Mecit
Earthquakes are among the most destructive and unpredictable natural disasters. Various diseases and ailments, such as bone fractures, organ and soft-tissue injuries, cardiovascular diseases, lung diseases, and infectious diseases, can develop in the aftermath of severe earthquakes. Digital ra-diography, ultrasound, computed tomography, and magnetic resonance imaging are significant imaging modalities utilized for the quick and reliable assessment of earthquake-related ailments to facilitate the planning of suitable therapy. This article examines the usual radiological imaging characteristics observed in individuals from quake-damaged regions and summarizes the strengths and functionality of imaging modalities. In such circumstances, where quick decision-making processes are life-saving and essential, we hope this review will be a practical reference for readers.
- MakaleYalnız künye2024Comparison of Selenic Acid and Pyruvic Acid-Loaded Silver Nanocarriers Impact on Colorectal Cancer Viability
Erdemir, Gökçe; DANIŞMAN-KALINDEMIRTAŞ, Ferdane; KARIPER, İshak Afşin; KURUCA, Dürdane Serap; ÖZERKAN, Dilşad
Colorectal cancer (CRC) is a leading cause of morbidity and death worldwide. As current cancer drugs are ineffective, new solutions are being sought in other fields, including nanoscience. Similarly, silver nanoparticles play an important role in the pharmaceutical industry as they act as anti-cancer agents with less harmful effects and are usually 1 to 100 nm in size. Selenic acid (SA) and pyruvic acid (PA) are involved in various metabolic pathways in cancer. For this reason, we decided to detect their influence on colorectal cancer using silver-based (Ag) nanocarriers. DLS, Zetasizer, SEM and UV-Vis analyses were used to characterize AgSA and AgPA. A UV spectrophotometer was used to analyze the release of the NPs. MTT analyses were used to measure the viability of HCT116 and HUVEC cells, and IC50 values were calculated using GraphPad Prism. The indicated dosage and particle size of AgSA NPs proved to be suitable for cytotoxicity. Moreover, injection of these nanoparticles into non-cancer cells proved safe due to their minimal toxicity. In contrast, the AgPA NPs have no cytotoxicity and induce proliferation of HCT116 cells. Finally, only the synthesised AgSA nanoparticles could be used for advanced cancer therapy, which is both inexpensive and has minimal side effects.
- MakaleAçık Erişim2024Design and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation
Durgun, Mustafa; Akocak, Suleyman; Lolak, Nebih; Topal, Fevzi; Koçyiğit, Ümit Muhammet; Türkeş, Cüneyt; Işık, Mesut; Beydemir, Şükrü
The present study focused on the synthesis and characterization of novel pyrazole carboxamide derivatives (SA1-12). The inhibitory effect of the compounds on cholinesterases (ChEs; AChE and BChE) and carbonic anhydrases (hCAs; hCA I and hCA II) isoenzymes were screened as in vitro. These series compounds have been identified as potential inhibitors with a KI values in the range of 10.69±1.27–70.87±8.11 nM for hCA I, 20.01±3.48–56.63±6.41 nM for hCA II, 6.60±0.62-14.15±1.09 nM for acetylcholinesterase (AChE) and 54.87±7.76–137.20 ±9.61 nM for butyrylcholinesterase (BChE). These compounds have a more effective inhibition effect when compared to the reference compounds. In addition, the potential binding positions of the compounds with high affinity for ChE and hCAs were demonstrated by in silico methods. The results of in silico and in vitro studies support each other. As a result of the present study, the compounds with high inhibitory activity for metabolic enzymes, such as ChE and hCA were designed. The compounds may be potential alternative agents used as selective ChE and hCA inhibitors in the treatment of Alzheimer′s disease and glaucoma.
- MakaleAçık Erişim2024Hyalinizing Clear Cell Carcinoma
Irgul, Baris; Aydin, Sonay; Issin, Gizem; Kantarci, Mecit
- MakaleYalnız künye2024Investigation of play skills of children with typical development and language and speech disorders according to demographic variables
Barmak, Elife; Aysu, Burçin; Aydoğdu, Fatih; Aral, Neriman; Uysal, Halil Tayyip
The purpose of this study was to examine the play skills of children with typical development and those with speech and language disorders (SLD) based on gender, the presence of siblings, and parents’ education levels. There were 270 children included in the study's sample. In the study, ‘The Play Behaviour Scale’ was used. Reticent behaviour scores of girls with SLD were significantly higher than those of boys, and scuffle play, scores of typically developing boys were significantly higher than those of girls. The social play scores of children with SLD were statistically significant when they had a sibling. Children whose parents had a high school education or less had considerably higher scuffle play ratings than children whose parents had a university degree or above. Consequently, it was observed that demographic variables influenced the play skills of children with SLD. Defining these children's play behaviours based on various variables will be beneficial for creating intervention programmes.
- MakaleAçık Erişim2024Quantification of Heavy Metals in the Nasal Turbines of Smokers and Nonsmokers
Öner, Fatih; Mazlumoğlu, Muhammet Recai; Kurt, Osman; Kurt, Nezahat; Ücüncü, Harun
Objectives: Cigarette smoke is known to contain toxic heavy metals. In this study, heavy metal levels in the nasal turbinate tissues of smokers and nonsmokers were measured and compared with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Methods: Forty patients who come to the Otorhinolaryngology outpatient clinic due to nasal obstruction and are given an appointment for partial turbinate reduction operation due to inferior turbinate hypertrophy, according to their smoking status, were divided into two groups: those who had smoked one pack/day for at least 10 years and those who had never smoked. The levels of heavy metals (Al, As, Ba, Cd, Cr, Co, Cu, Pb, Mn, Hg, Ni, Se, and Ag) were compared by ICP-MS in nasal turbinate tissues. Results: Al (p = 0.002), Cr (p < 0.001), Co (p < 0.001), Ni (p = 0.001), Cu (p < 0.001), As (p < 0.001), Se (p < 0.001), Ag (p < 0.001), Cd (p = 0.001), Ba (p = 0.008), Hg (p < 0.001), and Pb (p < 0.001) values in the smoker group were found to be significantly higher than the values of nonsmokers. Although the Mn level was high in smokers, no significant difference was observed (p = 0.299). Conclusions: Smoking can cause nasal and sinus problems. In this study, we observed that the smoking group had significantly higher levels of almost all the heavy metals investigated in the nasal turbinate tissues. As smoking damages, the mucociliary system and the mucosa, heavy metals from cigarettes may accumulate further and cause harm to the nasal tissues. Level of Evidence: 3 Laryngoscope, 134:3562–3567, 2024.
- MakaleAçık Erişim2024Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats
Bozkurt, Ayse; Karakoy, Zeynep; Aydin, Pelin; Ozdemir, Bengul; Toktay, Erdem; Halici, Zekai; Cadirci, Elif
This study aimed to examine the effect of Phosphodiesterase 4 (PDE4) inhibition on Aquaporin-5 (AQP5) and its potential cell signaling pathway in the ovarian ischemia reperfusion (OIR) model. Thirty adult female rats were divided into five groups: Group 1; Control: Sham operation, Group 2; OIR that 3 hour ischemia followed by 3 hour reperfusion, Group 3; OIR + Rolipram 1 mg/kg, Group 4; OIR + Rolipram 3 mg/kg, Group 5; OIR + Rolipram 5 mg/kg. Rolipram was administered intraperitoneally to the rats in groups 3-4 and 5 at determined doses 30 minutes before reperfusion. From ovary tissue; Tumor necrosis factor-a (TNF-α), Cyclic adenosine monophosphate (cAMP), Nuclear factor kappa (NF-κB), Interleukin-6 (IL-6), Phosphodiesterase 4D (PDE4D), Mitogen-activated protein kinase (MAPK) and AQP5 levels were measured by ELISA. We also measured the level of AQP5 in ovary tissue by real-time reverse-transcription polymerase chain reaction (RT-PCR). In the OIR groups; TNF-α, NF-κB, IL-6, MAPK inflammatory levels increased, and cAMP and AQP5 levels decreased, which improved with the administration of rolipram doses. Also histopathological results showed damaged ovarian tissue after OIR, while rolipram administration decrased tissue damage in a dose dependent manner. We propose that the protective effect of PDE4 inhibition in OIR may be regulated by AQP5 and its potential cell signaling pathway and may be a new target in OIR therapy. However, clinical studies are needed to appraise these data in humans.
- MakaleAçık Erişim2024Endovascular treatment for anterior cerebral artery occlusions
Ozdemir, Gokhan; Eren, Fettah; Aygul, Recep; Kizildag, Nazım; Kocaturk, Idris; Mammadi, Azer; Ersoy, Ayse Nur; Ildiz, Omer Faruk; Gunduz, Zehra Betul; Korez, Muslu Kazım
Background: We sought to examine the feasibility, safety and preliminary efficacy of anterior cerebral artery (ACA) occlusions in patients undergoing endovascular treatment. Methods: Four hundred five consecutive patients with large-vessel occlusion treated with endovascular treatment were analysed to identify all patients with acute ACA occlusion who underwent endovascular treatment. Results: Twenty had ACA occlusion (primary ACA occlusion: 9, rescue ACA occlusion: 11), 395 patients had other occlusions (internal carotid artery and MCA). The median [IQR] mRS score in the third month was significantly higher in the ACA-rescue occlusion group versus the ACA-primary occlusion group. The rate of haematoma in patients with ACA-occlusions was significantly higher compared with the ACA-primary occlusion group. Moreover, the three-month mortality rate was higher in patients with ACA-rescue than the patients with ACA-primary. Conclusions: Although endovascular treatment can be considered in patients with primary ACA occlusions, our data suggest that future clinical trials are needed to determine the efficacy of endovascular treatment for ACA occlusions. Unfavourable outcomes in our study were considered to occur in the rescue ACA occlusions.
- MakaleYalnız künye2024Hydrazide-Bridged Pyridazines for Cholinesterase Inhibitors: Synthesis, Characterizations, In Silico, and In Vitro Evaluation
Gursoy, Sule; Taskor Onel, Gulce; Turkmenoglu, Burcin; Bozbey Merde, Irem; Dilek, Esra; Hepokur, Ceylan; Algul, Oztekin
In this study, we investigate the inhibitory potential of a series of hydrazide derivatives bearing different substituents with the pyridazine structure (5 a–i and 6 a–f) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using a modified Ellman's method. The inhibitory profiles of the synthesized compounds were assessed by comparing their IC50 and Ki values. Our results demonstrate that all the compounds exhibit significant inhibitory activity against both AChE and BChE when compared to the reference compound, tacrine. Particularly, compound 6 a exhibited the highest activity against Electrophorus electricus AChE (EeAChE) with a Ki value of 3.26 nM, while compound 5 a displayed the most potent inhibition against equine BChE (eqBChE) with a Ki value of 0.94 nM. The compounds did not possess significant cytotoxicity action using the MTT assay on the cancer cell lines. The DPPH assays revealed that all the compounds have moderate antioxidant activities. Furthermore, molecular docking studies provided valuable insights into the interaction mechanisms of these compounds within the active sites of AChE and BChE crystal structures (PDB ID: 4EY7 and 4BDS, respectively). The above results indicated that the pyridazine-based compounds were a promising functional agent for the treatment of Alzheimer's disease.
- MakaleAçık Erişim2024Host Genetic Polymorphisms and Disease Severity in Pregnant Women with COVID-19 in Türkiye
Polat, Seher; Kiremitli, Sevil; Kiremitli, Tunay; Kirkinci, Ahmet; Kurnuç, Fatma Zehra; Arslan, Yusuf Kemal
Objective: The study aimed to analyze the association between coronavirus disease-2019 (COVID-19) disease severity and genetic susceptibility in pregnant women. Material and Methods: The research included 54 pregnant women with confirmed COVID-19 diagnosis. All volunteers were evaluated physically and biochemically. Angiotensin-converting enzyme (ACE)2 (p.T27A A>G, p.G326E G>A, p.K419T A>C, ACE (p.T776T A>G, and g.16471_16472delinsALU (I/D), AGTR1 c.*86A>C, methylenetetrahydrofolate-reductase (MTHFR) p.A222V C>T and PAI-1-844 G>A were analyzed. Results: The allele frequency was also compared with control groups of the different studies made on Turkish women. MTHFR “CT” genotype compared to “CC” had lower platelet counts (p=0.015). In ACE “ID” genotype, there was a lower D-dimer level compared to “DD” genotype (p=0.02). In PAI-1-844G>A, the AA vs. AG+GG genotype and AA vs. GG genotype elevate the risk of hospitalization 6.4-fold (OR: 6.4 95% (Cl): 1.6-25.8 p=0.009), and 4.6-fold (OR: 4.6 95% CI:1.0-21.6 p=0.049), respectively. In MTHFR p.A222V, to have CC vs. CT genotype increased the risk of enoxaparin and antibiotic use 4.1-fold and 3.2-fold at the borderline significance (OR: 4.1 95% Cl: 0.99-16.9 p=0.052 and OR: 3.2 95% Cl: 0.98-10.5 p=0.053), respectively. An allele frequency difference wasn't found between the patient and the healthy women related to the investigated polymorphisms. Conclusion: PAI-1-844G>A, MTHFR p.A222V, and ACE (I/D) associated with a poor COVID-19 outcome, the risk of enoxaparin and antibiotic use, and also increased risk of hospitalization. Allele frequencies of the genes were not different between healthy control women and women with COVID-19; genetic variation may not influence the risk of infection but disease severity.
- MakaleAçık Erişim2024Yogurt consumption in Türkiye, commercial use of yogurt yeast, and evaluation of consumers' attitudes toward yogurt-like products produced using different yeasts; [Türkiyede’ki yoğurt tüketimi, ticari olarak yoğurt mayasının kullanılması ve tüketicilerin farklı mayalıklar kullanılarak üretilen yoğurt benzeri ürünlere karşı tutumlarının değerlendirilmesi]
Yangilar, Filiz; Karaca, Özlem
This study aims to determine the consumption of ready-made and homemade yogurt, the level of knowledge about different yeasts (chickpea, dewdrop, sugar, cone, vinegar, etc.) that can be used while fermenting yogurt, and their attitudes toward using yogurt leavening in case it is sold commercially. The research was carried out with 500 participants, 427 females (85.4%) and 73 males (14.6%) between 18 and 74. 77.0% of the female participants and 61.6% of the men shared that they had fermented yogurt. 80.1% of the women and 84.9% of the men did not know about using different raw materials as leavening agents other than yogurt yeast. According to their educational status, 54.5% of associate degree graduates wanted yogurt yeast to be sold in the market, like rennet, 55.9% of postgraduate participants wanted to use it if it was sold, and 48.5% of them said yes to the reliability of yogurt yeast. In addition, the participants stated that they liked to consume yogurt in general, found homemade yogurt healthier, and made their yogurt.
- MakaleAçık Erişim2024Health-Related Cognitions and Metacognitions Indirectly Contribute to the Relationships Between Impulsivity, Fear of COVID-19, and Cyberchondria
Eşkisu, Mustafa; Çam, Zekeriya; Boysan, Murat
The aim of the study was to converge a structural equation model to unfold the compositive relationships between trait impulsivity, health cognitions, metacognitions about health, fear of COVID-19 and cyberchondria, after controlling for gender, age, marital status, having a chronic illness and chronic illness among first-degree relatives. Six hundred fifty-one participants (423 females, 65%; 228 males, 35%) participated in the study. The Short UPPS-P Impulsive Behavior Scale (S-UPPS-P), Health Cognitions Questionnaire (HCQ), The Meta-Cognitions about Health Questionnaire (MCQ-HA), Cyberchondria Severity Scale –Short Form (CSS-12), and Fear of COVID-19 Scale (FCV-19 S) were completed by volunteered participants. The structural model showed that the S-UPPS-P directly and indirectly contributed to the HCQ, MCQ-HA, CSS-12, and FCV-19 S. The multi-group structural analysis by gender showed that the structural model had a partial measurement and factorial invariance. We concluded that the significant associations between impulsivity, fear of COVID-19 and cyberchondria were indirectly contributed by health-related cognitions and metacognitions.
- MakaleAçık Erişim2024The effects of morin and methotrexate on pentose phosphate pathway enzymes and GR/GST/TrxR enzyme activities: An in vivo and in silico study
Caglayan, Cuneyt; Temel, Yusuf; Türkeş, Cüneyt; Ayna, Adnan; Ece, Abdulilah; Beydemir, Şükrü
In this study, the mechanisms by which the enzymes glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), glutathione reductase (GR), glutathione-S-transferase (GST), and thioredoxin reductase (TrxR) are inhibited by methotrexate (MTX) were investigated, as well as whether the antioxidant morin can mitigate or prevent these adverse effects in vivo and in silico. For 10 days, rats received oral doses of morin (50 and 100 mg/kg body weight). On the fifth day, a single intraperitoneal injection of MTX (20 mg/kg body weight) was administered to generate toxicity. Decreased activities of G6PD, 6PGD, GR, GST, and TrxR were associated with MTX-related toxicity while morin treatment increased the activity of the enzymes. The docking analysis indicated that H-bonds, pi–pi stacking, and pi–cation interactions were the dominant interactions in these enzyme-binding pockets. Furthermore, the docked poses of morin and MTX against GST were subjected to molecular dynamic simulations for 200 ns, to assess the stability of both complexes and also to predict key amino acid residues in the binding pockets throughout the simulation. The results of this study suggest that morin may be a viable means of alleviating the enzyme activities of important regulatory enzymes against MTX-induced toxicity.
- Derleme MakaleYalnız künye2024A Meta-Analysis of the Graduated Guidance Procedure
Tekin-Iftar, Elif; Ault, Melinda Jones; Collins, Belva C.; Olcay, Seray; Degirmenci, H. Deniz; Aydın, Orhan
We conducted a descriptive analysis and meta-analysis of single-case research design (SCRD) studies investigating the effectiveness of the graduated guidance procedure. Once we identified studies through electronic databases and reference lists, we used What Works Clearinghouse (WWC) Standards to evaluate each study. Then, we described studies in terms of various descriptive variables, calculated effect sizes through three non-parametric effect size methods, and analyzed results across studies. Results showed 11 of the 27 studies met WWC Standards or met standards with reservation. Of the 11, seven studies resulted in a large effect. We found the graduated guidance procedure to be an evidence-based practice when evaluating the findings against contemporary evidence standards. However, this review also showed that the majority of the reviewed studies (n = 20) had no effects and only one third of the studies had moderate or strong effects. Implications for researchers and practitioners are discussed.
- MakaleAçık Erişim2024Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Bengueddach, A.; Tidjane, A.; Tabeti, B.; Behilil, C.; Boudjenan-Serradj, N.; Bensafir, S.; Meharzi, S.E.I.; Aissat, A.; Ghouali, A.K.; Larabi, K.
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion: Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov).
- MakaleAçık Erişim2024Orthorexia nervosa predisposition and eating behaviors in hypertension patients: A case-control study
Yanmis, Safiye; Turan, Gülcan Bahçecioğlu; Özer, Zülfünaz
The aim of this case-control study is to evaluate whether there is a difference between individuals with hypertension and healthy individuals in terms of orthorexia nervosa and eating attitudes. This case-control study was conducted with hypertension patients (n=218) and healthy individuals (n=226) who met the research criteria in an internal medicine clinic and outpatient clinics of a university hospital between April and June 2021. The data were collected with face-to-face interview method by using ―Descriptive Information Form‖, ―Orthorexia Nervosa-11 (ORTO-11) Scale‖ and ―Eating Attitude Scale (EAT-26)‖. ORTO-11 score of HT patients was found as 26.39±4.96, while ORTO-11 score of healthy individuals was found as 27.58±4.26. EAT-26 score of HT patients was found as 9.87±7.88, while EAT-26 score of healthy individuals was found as 8.31±7.31. Statistically significant difference was found between me an ORTO-11 and EAT-26 scores of groups (p<0.05). Mean scores of 59% of HT patients and 41% of healthy individuals were found to be below ORTO-11 ≤ 27. Mean scores of 14.2% of HT patients and 10.1% of healthy individuals were found to be above EAT-26 ≥20. In the regression analysis, EAT-26 (β=-0.401, p<0.05) variable was found to have a negative and significant effect on ORTO-11. Higher orthorexia and eating disorder risk was found in hypertension patients when compared with healthy individuals. In addition, it was found that abnormal eat ing behaviour caused individuals to show more orthorexia behaviour.
- MakaleYalnız künye2024Chemical composition, antifungal, antibacterial, and insecticidal activity of Echinophora chrysantha essential oil
Akşit, Zeynep; Fırat, Mehmet Çağlar; Akşit, Hüseyin; Bayar, Yusuf; Alkan, Mustafa; Şimşek, Samed
This study presents an investigation of the chemical composition and biological activities of the essential oil (EO) extracted from aerial parts of Echinophora chrysantha (EC). Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of twenty-two components, representing 97.5% of the total oil. Major constituents were determined as α-phellandrene (55.74%), β-phellandrene (17.41%), and p-cymene (8.95%). The EO was screened for antimicrobial and antifungal activity against a panel of bacteria and fungi using a broth micro-dilution and fumigant activity assay, respectively. EO sample exhibited better activity against Listeria monocytogenes, Staphylococcus aureus Enterococcus faecium with 31.25, 31.25, and 62.5 μg/mL MIC values. EOs showed moderate mycelium growth inhibitory activity against Phytophthora infestans (32.9±1.9%), Verticillium dahliae (42.3±1.8%), and Fusarium oxysporum f. sp. lycopersici (53.0±2.9%) at 8 μL/petri concentration. The insecticidal activity of EO was also evaluated against two insects (Rhyzopertha dominica and Tribolium confusum) showing moderate activity with mortality rates of 25.8±0.6% and 37.9±1.2% at a 5% (v/v) concentration. Literature search has not revealed any previous work on the antimicrobial, antifungal, and insecticidal activities of the EO from E. chrysantha. In conclusion, this is the first report describing the biological activities of this plant EOs. Additionally, these findings highlight the practical implications of the utilizing essential oil of EC as a potential natural remedy against a spectrum of microbial threats in both pharmaceutical and food preservation applications.
- MakaleAçık Erişim2024Health anxiety model of cyberchondria, fears, obsessions, sleep quality, and negative affect during COVID-19
Yalçın, İlhan; Boysan, Murat; Eşkisu, Mustafa; Çam, Zekeriya
The aim of the study was to explore the relationships among cyberchondria, fear of COVID-19, health anxiety, obsessions, sleep quality, and negative affect in a national community sample of Turkish participants. A sample of 8,276 volunteers, aged between 18 and 65, were recruited via an online platform. The Perceived Vulnerability about Diseases Questionnaire, Fear of COVID-19 Scale, Cyberchondria Severity Scale, Short Health Anxiety Inventory, Depression Stress Anxiety Scale-21, Obsessive–Compulsive Inventory–Revised, and Pittsburgh Sleep Quality Index were completed by participants. Data were analyzed using mixture structural equation modelling approach. Results revealed that perceived vulnerability to disease was found to be positively related with cyberchondria, poor sleep quality, health anxiety, and obsessive–compulsive symptoms. Negative affect was positively associated with obsessive–compulsive symptoms, fears of COVID-19, cyberchondria severity, and poor sleep quality. Additionally, fear of COVID-19 was positively related to health anxiety. Also, cyberchondria severity was found to be positively associated with poor sleep quality and obsessive–compulsive symptoms. Mixture analysis classified participants into six latent classes: 1) Risk-Aversive Healthy Group, 2) Incautious Healthy Group, 3) Infection Obsessions Group, 4) Health Anxiety Group, 5) Negative Affect Group, and 6) General Psychopathology Group. The national survey data showed that perceived vulnerability to diseases, negative affect, fear of COVID-19, cyberchondria, health anxiety, obsessive–compulsive symptoms, and sleep quality appeared to be at the center of pandemic health anxiety.
- MakaleYalnız künye2024Modification and Validation of the Vaccine Hesitancy Scale for Turkish Adult Vaccination
Çelik, Hakan; Özer, Mustafa; Zincir, Handan
Background and Purpose: For public health, it is important to investigate vaccine hesitancy, determine populations reluctant for vaccines, and investigate barriers and facilitators for vaccination in these groups. This study aims to modify and validate the Vaccine Hesitancy Scale specific to adults in Turkish society. Methods: The study, which was designed as a methodological and survey type, was conducted using a Google questionnaire with 720 participants who met the inclusion criteria with a convenient sampling method. Results: After factor and reliability analysis, a 2-factor, 10-item scale with an acceptable and perfect range of fit index values emerged. It has been observed that individuals who are young, single, do not have children, have vaccine allergy, and do not believe that the vaccine will protect the society are adversely affected by the environment, and those who do not have COVID-19 and flu have a high level of hesitancy to vaccine. Conclusions: The Vaccine Hesitancy Scale is a valid and reliable tool to detect vaccine hesitation in adults in Turkish society.
