Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

Yazarlar

Yayınlar

Yeniden eskiyeEskiden yeniye
  • ArticleAçık Erişim2026
    65 Yaş Üzeri Bireylerin Yaşlılığı Algılama Düzeylerinin Aktif Yaşlanma Sürecine Etkisi: Tanımlayıcı Çalışma

    Demir, Sevgi; Güneş, Demet; Demirkıran, Bedriye Cansu

    Amaç: Bu çalışma, yaşlı bireylerin yaşlılığı algılama düzeyle rini belirleyip, aktif yaşlanma sürecine etkisini değerlendirmek ama cıyla yapılmıştır. Gereç ve Yöntemler: Tanımlayıcı ve ilişki arayıcı nitelikte yapılan bu çalışma, Doğu Karadeniz bölgesinde bulunan bir devlet hastanesine başvuran 65 yaş üzeri 305 birey ile yürütülmüştür. Veriler, araştırmacı tarafından gerekli izinler alındıktan sonra yüz yüze görüşme tekniği ile tanımlayıcı bilgi formu, Yaşlılığı Algılama Anketi Kısa Formu ve Aktif Yaşlanma Ölçeği kullanılarak toplanılmıştır. Bul gular: Çalışmamızda, Yaşlılığı Algılama Ölçeği puan ortalamasının 53,66±11,19, Aktif Yaşlanma Ölçeği puan ortalamasının 122,18±53,49 olduğu belirlendi. Cinsiyet, birlikte yaşama durumu ile Yaşlılığı Algı lama Ölçeği ve çocuk sayısı, eğitim durumu, meslek durumu, katılım cıların sağlığı algılama durumu, kronik hastalık durumu, kronik hastalık tanısı ile Aktif Yaşlanma Ölçeği arasında anlamlı bir ilişki olduğu bu lundu (p<0,05). Yerleşim yeri, medeni durumu, gelir durumu ile Yaş lılığı Algılama Ölçeği ve Aktif Yaşlanma Ölçeği toplam puan ortalaması arasında anlamlı bir fark bulunmamıştır (p˃0,05). Yaş ile aktif yaşlanma arasında negatif yönde orta düzeyde, yaşlılığı algılama ile aktif yaşlanma arasında negatif yönde orta düzeyde ilişki olduğu be lirlendi. Yaşlılığı algılamanın aktif yaşlanma üzerinde anlamlı bir etki sinin olduğu belirlendi (t=-3,756, p<0,05). Sonuç: Yaşlılığı algılamanın, aktif yaşlanma üzerinde olumlu bir etkisinin olduğu bu lunmuştur. Yaşlılığı algılamaya yönelik yapılacak olan hemşirelik gi rişimleri ve müdahaleler bireylerin, aktif yaşlanma sürecinin iyi yönetilmesine katkı sağlayacaktır.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    COVID-19 Pandemi Döneminde Erzincan Kent Merkezinde Trafik Kazalarının Zaman-Mekân Küpü Yöntemiyle Zamansal – Mekânsal Analizi (2020-2023)

    Kesik, Ozan Arif; Güney, Ertuğrul

    Bu çalışma, 2020-2023 döneminde Erzincan kent merkezinde meydana gelen ölümlü ve yaralanmalı trafik kazalarının zamansal ve mekânsal dinamiklerini, COVID-19 pandemisinin etkileri bağlamında incelemektedir. Erzincan, Doğu Anadolu Bölgesi’nde bin kişi başına düşen araç sayısında birinci sırada yer alması ve düşük nüfusuna rağmen yüksek kaza istatistikleri göstermesi nedeniyle çalışma alanı olarak seçilmiştir. Araştırmada; Sıcak Nokta Analizi (Getis-Ord Gi*), Kernel Yoğunluk Analizi ve Zaman-Mekân Küpü Analizi yöntemleri kullanılarak kazaların dağılımı haritalanmıştır. Ayrıca, Analitik Hiyerarşi Süreci (AHP) ile kaza risk faktörleri ağırlıklandırılmıştır. Bulgular, COVID-19 kısıtlamalarının yaşandığı 2020 yılında kaza sayılarında belirgin bir düşüş yaşandığını, ancak normalleşme süreciyle birlikte 2023 yılında kaza ve yaralı sayılarının pandemi öncesi seviyeleri aşarak zirve yaptığını ortaya koymuştur. Mekânsal analizler, kaza riskinin Dörtyol kavşağı ve ana arterler üzerinde "yoğunlaşan sıcak nokta" karakteri sergilediğini; AHP sonuçları ise trafik yoğunluğu (%46) ve hızın (%33) temel risk faktörleri olduğunu kanıtlamıştır. Çalışma, elde edilen bulgular ışığında, riskli kavşaklar ve trafiğin zirve yaptığı saatler için yerel ölçekte uygulanabilir trafik güvenliği stratejileri sunmaktadır.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Annelerin Tamamlayıcı Beslenmeye Yönelik Tutum ve Uygulamaları ile Bebeklerin Tamamlayıcı Beslenmeye Geçiş Davranışlarının İncelenmesi

    Akça, Kamile; Şahin, Ayşe; Özcan, Meltem

    Amaç: Annelerin tamamlayıcı beslenmeye yönelik tutum ve uygulamaları ile bebeklerin tamamlayıcı beslenmeye geçiş davranışlarının incelenmesi amacıyla yapılmıştır. Yöntem: Araştırma, tanımlayıcı ve kesitsel türde olup Mart-Temmuz 2023 tarihleri arasında 6–24 ay arası bebeği olan 220 anne ile yapılmıştır. Veriler, ‘‘Anneye ve Bebeğe ait Tanıtıcı Bilgi Formu’’, ‘‘Annelerin Tamamlayıcı Beslenmeye Yönelik Tutum ve Uygulamaları Anketi’’ ve ‘‘Tamamlayıcı Beslenmeye Geçiş Davranışları Ölçeği’’ kullanılarak toplanmıştır. Bulgular: Çalışmaya katılan annelerin %57.3’ünün emzirmeye devam ettiği belirlenmiştir. Annelerin, tamamlayıcı beslenmede en sık kullandığı besinin yoğurt olduğu, %60.9’unun beslenmeye ilişkin bilgiyi sağlık çalışanından aldığı, %53.6’sının birkaç gün ara ile yeni besine geçtiği saptanmıştır. Tamamlayıcı beslenmeye geçiş davranışları ölçeğinin puan ortalamasının 110.24±17.50 olduğu tespit edilmiştir. Sonuç: Çalışmada; gelir düzeyi, annenin çalışma ve emzirmeye devam etme durumu, bebeğin cinsiyeti, çocuk sayısı ve tamamlayıcı beslenmeye geçiş zamanının, tamamlayıcı beslenmeye geçiş davranışlarını etkilediği sonucuna varılmıştır. Annelerin tamamlayıcı beslenme konusunda bilgi düzeylerinin artırılmasına yönelik eğitim faaliyetlerinin planlanması, tamamlayıcı beslenme sürecinin daha doğru ve sağlıklı geçirilmesini sağlayacaktır.

    • SDG 2 · Açlığa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleYalnız künye2026
    Bireylerin Deprem Korkusu ve Deprem Hazırlık İnancı Arasındaki İlişkinin Belirlenmesi

    Tercan, Bahadır; Akgül, Fatma

    Bu çalışmanın amacı, bireylerin deprem korkusu ve depreme hazırlık inançları arasındaki ilişkinin belirlenmesidir. Türkiye'de yaşayan 18 yaş ve üzeri bireyler ile yürütülen kesitsel, tanımlayıcı ve ilişki arayıcı bir çalışma olarak tasarlanmıştır. Çalışmanın verileri Nisan-Haziran 2025 tarihleri arasında "Sosyo-Demografik Bilgi Formu", "Deprem Korkusu Ölçeği" ve "Depreme Hazırlık İnançları Ölçeği" kullanılarak toplanmıştır. Sonuçlara göre kadınların, evli olanların, afet eğitimine sahip olmayanların, genç ve orta yaş grubunda olan bireylerin daha yüksek deprem korkusu puanlarına sahip olduğu belirlenmiştir. Buna karşılık, genç ve orta yaş grubunda bulunan, lisans ve lisansüstü eğitim düzeyine sahip ve orta ile yüksek sosyoekonomik düzeyde yer alan bireylerin depreme hazırlık inanç puanlarının daha yüksek olduğu saptanmıştır. Deprem korkusunun, deprem hazırlık inancını anlamlı düzeyde yordadığı tespit edilmiştir. Yani, deprem korkusu arttıkça, deprem hazırlık inancı da artmaktadır. Bireylerin depreme hazırlık inançlarının korku düzeyi açısından ele alınması, toplum temelli afet risk azaltma ile katılım odaklı politika ve müdahalelerin geliştirilmesine katkı sağlayabilir. Bunun yanı sıra, bireylerin çağdaş afet yönetimi süreçlerinde daha aktif ve sorumluluk alan bir rol üstlenmelerini destekleyebilir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Kafeinin ağızda çalkalanmasının aralıklı koşu performansı üzerine etkisi: gün zamanı

    Akcan, İbrahim Orkun; Karayigit, Raci; Kayabaş, Oğulhan

    Kafeinin ağızda çalkalanmasının (KAÇ) aralıklı koşu performansı iyileştirdiğine yönelik çalışmalar literatürde yer almaktadır. Bununla birlikte, bu iyileştirme etkisinin günün farklı zamanlarında nasıl bir etki göstereceği tam olarak bilinmemektedir. Bu araştırmanın amacı, benzer sirkadiyen ritme sahip sporcularda farklı gün zamanı dilimlerinde KAÇ uygulamasının aralıklı koşu performansına etkisini incelemektir. Araştırmaya 14 sağlıklı ve kronotipleri ara tip olan amatör sporcu katılmıştır. Katılımcılar 4 farklı test protokolüne randomize bir şekilde dağıtılmış, çift kör ve çapraz döngülü bir çalışma dizaynında, sabah (10.00) ve akşam (18.00) olmak üzere 25 ml plasebo ve kafein (300 mg) solüsyonlarını 8 kez ve 5’er saniye çalkalayarak aralıklı koşu testini (Yo-Yo IRT1) tamamlamışlardır. Her bir katılımcı, sabah plasebo ve kafein çalkalama, akşam plasebo ve kafein çalkalama testlerini gerçekleştirmiştir. Testlerin sonunda katılımcıların zirve kalp atım hızları (KAH) ve algılanan zorluk dereceleri (RPE) ölçülmüştür. Koşu testlerinin sonucunda, KAÇ uygulamasının plaseboya kıyasla koşu performansı süresini artırdığı (%10) (p0.05). KAH ve RPE ölçümlerinde testler arasında anlamlı bir farklılık olmadığı da tespit edilmiştir (p>0.05). Sonuç olarak, KAÇ uygulaması plaseboya kıyasla koşu performansını artırırken, iki farklı gün zamanı arasında istatistiksel olarak anlamlı bir farklılık yaratmamaktadır. Özellikle ara tip kronotipe sahip olan amatör sporcularda, KAÇ uygulamasının faydasını farklı gün zamanlarında görebilmek mümkün olabilmektedir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Diagnostic Comparison of MRI/Ultrasound Fusion Biopsy and Systematic Biopsy in PI-RADS 4-5 Prostate Lesions

    Levent, Akın; Durmaz, Önder

    Objective: Multiparametric magnetic resonance imaging (mpMRI) has transformed prostate cancer (PCa) diagnosis by enabling lesion-targeted biopsies. The optimal biopsy approach—systematic biopsy (SB), MRI-ultrasound fusion targeted biopsy (TB), or their combination (CB)—remains debated, especially in patients with high-risk Prostate Imaging-Reporting and Data System (PI-RADS) 4-5 lesions. This study compared these strategies for detecting overall and csPCa. Methods: This retrospective study included 330 patients who underwent MRI-ultrasound fusion TB with 12-core SB between July 2022 and May 2025. Only lesions classified as PI-RADS v2.1 category 4 or 5 were analyzed. Detection rates of overall PCa and csPCa (Gleason score ≥ 7) were compared among SB, TB, and CB. Subgroup analyses were performed by PI-RADS category and lesion location (anterior, middle, posterior). Logistic regression identified independent predictors of csPCa. Results: A total of 429 lesions were evaluated. Overall, PCa detection rates were 62% for SB, 70% for TB, and 77% for CB (P < 0.001); the corresponding csPCa rates were 47%, 56%, and 63% (P < 0.001). TB detected csPCa more effectively than SB (56% vs. 47%, P < 0.01). PI-RADS 5 lesions had higher detection rates than PI-RADS 4 lesions across all methods. CB achieved the highest rates in all locations, especially in anterior and middle lesions. Age, positive digital rectal examination, prostate-specific antigen density, prior biopsy, and PI-RADS category 5 were independent predictors of csPCa. Conclusion: In PI-RADS 4–5 lesions, combined SB and TB provide the highest detection rate for csPCa. While TB improves selective detection, SB remains essential to avoid missing significant disease.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    The Relationship Between Mammographic Features of BI-RADS 4 and 5 Calcifications and Pathological Diagnoses

    Babatürk, Andelib; Kaymaz, Esin; Seyfettin, Ayça; Eskalen, Zeynep; Büyükceran, Emre Utkan; Memis, Kemal Bugra; Gültekin, Serap

    Objective: To evaluate the relationship between mammographic features of BI-RADS category 4 and 5 breast calcifications and their corresponding pathological diagnoses, and to determine whether specific morphological or distribution patterns are predictive of malignancy. Methods: This retrospective study included 54 patients who underwent biopsy for suspicious breast calcifications between August 2021 and March 2024. Among these patients, 30 underwent stereotactic vacuum-assisted biopsy, and 24 underwent wire-guided localization followed by excisional biopsy. The mammographic morphology and distribution patterns of the calcifications were assessed using the BI-RADS lexicon, and the corresponding histopathological diagnoses were recorded. The association between mammographic features and pathological outcomes was subsequently analyzed. Results: Fine pleomorphic calcifications were the most common morphology (40.7%). A grouped distribution was the predominant pattern (61.1%). Benign lesions were mostly categorized as BI-RADS 4A, B3 lesions as BI-RADS 4B, and DCIS cases as BI-RADS 4C (P = 0.03). The Grouped distribution was more frequent among benign and B3 lesions, whereas DCIS exhibited more frequent linear and segmental patterns (P = 0.01). Malignancy rates were highest for fine linear/branching and fine pleomorphic morphologies. Conclusion: A significant association exists between the mammographic characteristics of BI-RADS 4 and 5 calcifications and their pathological outcomes. In our study, fine pleomorphic morphology and linear or segmental distribution patterns consistently indicated a increased likelihood of malignancy, particularly ductal carcinoma in situ, whereas benign and B3 lesions were more commonly associated with grouped distribution patterns. These results highlight that detailed evaluation of calcification morphology and distribution on mammography can improve diagnostic confidence, aid in distinguishing higher-risk lesions, and contribute to more informed biopsy decision-making.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Evaluation of Aortic and Pulmonary Artery Diameters Using Computed Tomography Angiography

    Kabalci, Halime; Gülmez, Ali Osman

    Objective: The truncus pulmonalis, the main pulmonary artery (MPA), originates from the right ventricle at the level of the upper edge of the left third rib cartilage and carries blood to both lungs. After a short course, it branches into two arteries beneath the aortic arch: the right pulmonary artery (RPA) and the left pulmonary artery (LPA). The aorta, the main artery that carries blood to the body, originates from the left ventricle. It is divided into three sections: the ascending aorta (AA), the aortic arch, and the descending aorta. Methods: Between January and December 2023, the files of adult patients who were suspected of having pulmonary embolism and who underwent thoracic CT angiography (CTA) at the Erzincan Mengücek Gazi Training and Research Hospital Emergency Department were reviewed. The patients’ DICOM-format images were exported. These images were uploaded to the 3D-Slicer (version 5.10.0 for Windows) and the MPA, RPA, LPA, and AA diameters were measured in the axial plane. The MPA-to-AA diameter ratio was calculated for each patient and designated PA:A. Results: This study included 52 men and 50 women, for a total of 102 patients. The patients’ average age was 67. No significant difference in vessel diameters was observed between genders. AA, MPA, RPA, and LPA diameters were higher in the >67 age group than in the ≤67 age group. There was no significant difference in the PA:A ratio between age groups. A positive, moderate, and statistically significant correlation was found between age and the diameters of AA, MPA, RPA, and LPA. No significant correlation was found between age and the pulmonary artery-to-aorta (PA:A) ratio. A strong, positive, and statistically significant correlation was found between MPA diameter and the diameters of RPA and LPA. A positive, moderately significant correlation was found between MPA diameter and AA diameter. A strong, significant positive correlation was found between RPA diameter and LPA diameter. Conclusion: Aortic and pulmonary artery diameters have been evaluated using various methods in previous studies. To better understand the clinical importance of aortic and pulmonary artery diameters in cardiopulmonary diseases, it is necessary to know their normal reference values. The Framingham Heart Study reported an average MPA diameter of 25.1 mm and an average PA:A ratio of 0.77. In our study of the Turkish population, the mean AA, MPA, RPA, and LPA diameters were 34.1 mm, 25.9 mm, 21.1 mm, and 20.2 mm, respectively, and the PA:A ratio was 0.78. Further studies in larger populations are needed to establish reference values for aortic and pulmonary artery diameters in healthy individuals.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Investigation of Nailfold Capillary Structures Using Digital Dermatoscopy in Rheumatological Diseases

    Ozdemir, Sevki; Sari, Haticetul Kubra

    Objective: Evaluating the microvascular structure in rheumatological diseases provides important information for understanding the pathogenesis and clinical management of these diseases. Nail capillaroscopy is a reliable method that allows non-invasive examination of these changes. This study aimed to evaluate nail capillary findings in rheumatological diseases using digital dermoscopy and to compare capillary patterns in different disease groups. Methods: The study included 200 patients diagnosed with rheumatological diseases and 50 healthy volunteers. The nail bed capillaries of all participants were evaluated using a digital dermatoscope. Capillary examination assessed the presence of edema, tortuous, elongated, dilated, and brush-like capillaries, microhemorrhages, and avascular areas. Statistical analyses were performed using appropriate parametric and non-parametric tests, and a P value < 0.05 was considered statistically significant. Results: The frequency of capillary abnormalities was significantly higher in the patient group than in the control group. The most frequently observed findings were edema and tortuous, elongated capillaries. Capillary patterns differed by disease group, with more specific findings particularly prominent in patients with systemic sclerosis. Conclusion: Nail capillaroscopy is an effective, easily applicable, and non-invasive method for evaluating microvascular changes in rheumatological diseases. Capillary patterns observed in different disease groups can provide clinically valuable information for diagnosis and disease monitoring.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Clinical Characteristics of Geriatric Patients Admitted to the Emergency Department and Evaluation According to Age Groups

    Bilgin, Yasin; Kantar, Yusuf; Tanrıverdi, Orhan; Sari, Fatih Mehmet; Çimen, Erdem Yakup; Yurttutan, Abdullah Emre

    Objective: To evaluate the demographic and clinical characteristics, reasons for admission, triage distribution, consultation requests, and hospitalization rates of geriatric patients presenting to a tertiary emergency department, and to examine the associations between age groups and emergency department utilization patterns and outcomes. Materials and Methods: This retrospective and descriptive study was conducted among patients aged 65 years and older who presented to the emergency department of Mengücek Gazi Training and Research Hospital between July 1, 2024, and June 30, 2025. Data on demographic characteristics, triage categories, reasons for admission, consultation requests, hospitalization status, emergency department outcomes, and repeat visits were obtained from the hospital information management system. The data were analyzed using descriptive statistical methods. Results: A total of 18,269 geriatric patients were included in the study. The mean age was 74.0 ± 7.2 years, and 54.5% of the patients were female. The highest proportion of admissions was observed in the 65-74 age group. Hospitalization occurred in 11.4% of cases. As age increased, ambulance admissions, repeat emergency department visits, and hospitalization rates increased significantly (P < 0.05). The most common reasons for admission were musculoskeletal, respiratory, and cardiovascular diseases. Conclusion: This study demonstrates that geriatric patients presenting to the emergency department exhibit distinct clinical and utilization characteristics by age group. The findings indicate that patients in older age groups require more complex clinical evaluation and tailored care during management in the emergency department.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Comparison of the Syringe Preparation Time for Ranibizumab Prefilled Syringe versus Bevacizumab, Ranibizumab, and Aflibercept Vials

    Uğurlu, Adem; Taşlı, Nurdan Gamze; Karakurt, Yucel; Somuncu, Ahmet Mehmet; Çiçek, İbrahim

    Objective: To compare the syringe preparation time for ranibizumab prefilled syringe versus bevacizumab, ranibizumab, and aflibercept vials in routine retinal practice. Methods: The study was conducted retrospectively between July 2019 and February 2021 at the Ophthalmology Department of the Erzincan Binali Yıldırım University Faculty of Medicine, Türkiye. Syringe preparation times for 157 eyes were collected for the study. For each injection, one independent observer recorded the duration of each step required to prepare the syringe, starting with the removal of the ranibizumab prefilled syringe or bevacizumab, ranibizumab, and aflibercept vials from their respective packaging, and ending at the moment the dose was ready for injection. Injections were excluded if disruptions during the drug administration process were due to external factors or if other errors occurred in measuring preparation time. In addition to preparation time, formation of air bubbles during syringe preparation was qualitatively observed. Results: Forty-five eyes were treated with the ranibizumab prefilled syringe, while bevacizumab, ranibizumab, and aflibercept vials were used to treat 40, 36, and 36 eyes, respectively. The mean injection preparation time was 46.5±4.8 s for the syringe and 66.1±7.2 s, 64.2±5.1 s, and 74.7±8.5 s for the bevacizumab, ranibizumab, and aflibercept vials, respectively. Air bubble formation was more frequently observed in the vial groups, particularly in the aflibercept group, than in the prefilled syringe group. Conclusion: The ranibizumab-prefilled syringe required fewer preparation steps and had a lower incidence of bubble formation compared with other vials. Specifically, when preparing the aflibercept vial for injection, dose adjustment took longer than for the bevacizumab and ranibizumab vials, primarily due to air bubbles.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Diagnostic Performance of the BioFire® Joint Infection Panel in Native Septic Arthritis and Periprosthetic Joint Infection: A Retrospective Diagnostic Accuracy Study

    Gür, Volkan; Akyüz, Sümeyye; Yapici, Furkan; Gülhan, Barış; Doğan, İbrahim; Gökgöz, Mehmet Burak; Ozturk, Akin; Topaluğurlu, Nedim Batuhan; Dündar, Harun

    Objective: Rapid identification of causative microorganisms is essential in suspected native septic arthritis and periprosthetic joint infection. This study evaluated the diagnostic performance of the BioFire® Joint Infection Panel and assessed its agreement with conventional culture and systemic inflammatory biomarkers. Methods: Hospital records from January 2025 to April 2026 were retrospectively reviewed. Of 115 screened patients with suspected joint infection, nine were excluded because BioFire® testing had not been performed and only culture results were available. The final analysis included 106 synovial fluid samples. All samples were tested using conventional culture and the BioFire® Joint Infection Panel during the same clinical episode. Demographic data, infection category, localization, C-reactive protein, erythrocyte sedimentation rate, procalcitonin, and white blood cell count were recorded. Agreement was assessed using Cohen’s kappa, discordance using the McNemar test, and diagnostic performance using culture as the reference method. Results: Sixty-five samples (61.3%) were classified as suspected native septic arthritis and 41 (38.7%) as periprosthetic joint infection. BioFire® was positive in 22 samples (20.8%) and culture was positive in 32 (30.2%). Overall agreement was 86.8%, with substantial agreement according to Cohen’s kappa (0.656). Discordance was significant, predominantly due to culture-positive/BioFire®-negative samples (P = 0.013). BioFire® showed 62.5% sensitivity [95% confidence interval (CI): 43.7-78.9), 97.3% specificity (95% CI: 90.6-99.7), 90.9% positive predictive value, 85.7% negative predictive value, and 86.8% accuracy. C-reactive protein, procalcitonin, and white blood cell counts were significantly higher in patients with suspected native septic arthritis. Conclusion: The BioFire® Joint Infection Panel provides rapid and highly specific microbiological support in suspected joint infection. However, its moderate sensitivity and inability to detect off-panel organisms indicate that it should complement rather than replace conventional culture.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • Review ArticleAçık Erişim2026
    Pharmacological Modulation of Mitochondrial Dysfunction in Experimental Models of Hepatic Injury

    Bilgin, Aslı Özbek

    Mitochondrial dysfunction plays a central role in the pathogenesis of various liver diseases, ranging from drug-induced liver damage to steatotic liver disease associated with metabolic dysfunction. This review synthesizes recent advances in pharmacological strategies targeting mitochondrial quality control mechanisms. The shift from non-specific antioxidants to mitochondria-targeted agents is highlighted, as are the emerging roles of cardiolipin stabilizers (SS-31), next-generation cyclophilin inhibitors (Rencofilstat, C105SR), and modulation of immunometabolic pathways such as cGAS-STING and NLRP3. The transition of these promising experimental agents to clinical applications is also presented.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Quantifying Clinical Pharmacy Research ın Intensive Care Unit: Bibliometric Analysis Using VOSviewer

    Koç, Alparslan; Polat, Eyup Can

    Objective: Clinical pharmacy is a health field that is spreading all over the world. Numerous studies have demonstrated that clinical pharmacy services offered to healthcare providers lead to improved therapeutic outcomes. Intensive care units are the primary clinics where clinical pharmacists work. Due to factors such as variable clinical conditions of patients and the use of multiple medications, drug-related problems are frequently encountered in intensive care units. This study aims to conduct a comprehensive bibliometric analysis of research on clinical pharmacy in intensive care units by examining productivity trends, citation impact, collaboration networks, and thematic evolution using VOSviewer software. Methods: We used all relevant studies from the Web of Science database published between 1981 and 2024 that included the keywords "intensive care unit" and "clinical pharmacy" for this analysis. The analyses were performed using the VOSviewer (v1.6.20) software. Results: A total of 866 publications were analyzed. The country with the most publications was the United States. Original research articles were the most common publication type, and the most cited article was by Tsuji et al. (n=535). The most frequently used keywords were "critical care", "intensive care unit", "clinical pharmacy", and "clinical pharmacist". Conclusion: Our results show that research on clinical pharmacy in intensive care units is increasing steadily every year and that the services provided in these settings have a beneficial effect on treatment outcomes. Therefore, our study will be an important guide for researchers investigating clinical pharmacy services in intensive care units.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    In vitro evaluation of the antimicrobial, antioxidant, and cytotoxic effects of Zingiber officinale Roscoe ethanolic extract on A2780 ovarian cancer cells

    Gunay, Murat; Akyüz, Sümeyye; Akyüz, Emrullah

    Aim: To evaluate the in vitro antimicrobial, antioxidant, and anticancer activities of the ethanol extract obtained from Zingiber officinale Roscoe rhizomes (ZRE) against the A2780 ovarian cancer cell line. Materials and Methods: Antimicrobial activity was assessed using disk diffusion and broth microdilution methods. Antioxidant capacity was determined by DPPH and ABTS radical scavenging assays. Anticancer effects were investigated via the XTT cell viability assay. Results: The highest antimicrobial activity was observed against Staphylococcus aureus (16,67±0,57 mm, MIC 64 μg/mL) and Candida albicans (18,67±0,57 mm, MIC 64 μg/mL). Strong, concentration-dependent antioxidant activity was detected in both DPPH and ABTS assays. The IC₅₀ values in the A2780 cell line were determined to be 185±12 μg/mL at 24h and 92±8 μg/mL at 48h. Conclusion: ZRE exhibited notable antimicrobial activity, potent antioxidant capacity, and cytotoxic effects. The originality of this study lies in the simultaneous investigation of ZRE’s multifaceted biological activities.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Comprehensive MEFV Variant Spectrum in Pediatric Patients with Suspected Familial Mediterranean Fever: A Whole-Gene Sequencing Study

    Gunay, Murat; Demir, Abdussamed Yasin; Yeter, Bahtinur

    Objective: To determine the Mediterranean Fever (MEFV) variant spectrum using whole-gene next-generation sequencing (NGS) in pediatric cases with suspected Familial Mediterranean Fever (FMF). Methods: This retrospective cross-sectional study included 471 pediatric cases referred for MEFV analysis. All exons were analyzed using NGS, and variants were classified according to American College of Medical Genetics and Genomics criteria. Results: At least one MEFV variant was detected in 59.4% of cases. A total of 23 variants were identified, predominantly in exon 10 (43.5%) and exon 2 (34.8%). The most frequent variants were R202Q (43.3%), E148Q (16.3%), and M694V (13.7%). A low-frequency variants of uncertain significance, G150R, was detected in one case. Heterozygous genotypes were the most common (59.6%). Conclusion: Whole-gene sequencing enables the detection of both common and rare MEFV variants that may be missed by limited mutation panels. However, frequently detected variants, such as R202Q, require careful interpretation because of their high population frequency and controversial pathogenicity.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Kadınların Yaşadıkları Finansal Sıkıntılar ve Çözüm Önerileri Üzerine Bir Araştırma

    Sarı, Sali̇m Sercan; Karabulut, Turgut

    Kadınların karşı karşıya kaldıkları ekonomik sıkıntı ve finansal zorlukların temel nedenlerini inceleyen araştırmalar artan bir ilgi görmektedir. Araştırmanın amacı, kadınların yaşadıkları finansal sıkıntıları ve bunların nedenlerini ortaya koymak, ardından çözüm önerileri sunarak finansal refahlarını artırmaktır. Veri toplama kısmında kullanılan finansal sıkıntı anketi Erzincan ilinde yaşayan kadınlara uygulanmıştır. Bu veriler SPSS 27 programı kullanılarak analiz edilmiştir. Verilerin analizinde güvenirlik, faktör, bağımsız örneklem t testi ve tek yönlü varyans analizleri kullanılmıştır. Bulgular, kadınların medeni durumu, eğitim durumu, çalışma durumu ve konut mülkiyet durumu ile yaşadıkları finansal sıkıntı arasında anlamlı farklılıklar olduğunu göstermiştir. Kadınların finansal bilgi düzeylerinin yeteri düzeyde olduğu ortaya konmuştur. Ayrıca ikili ilişkilerde, fiziksel ve psikolojik durumlarda, kredi kartı kullanımında ve fatura ödemelerindeki sıkıntıların düşük düzeyde olduğu saptanmıştır. Sonuçta ise genel olarak finansal sıkıntı yaşama düzeylerinin düşük olduğu görülmüştür. Bu sonuçlar ışığında kadınların herhangi bir finansal sıkıntı belirtisi görmeye başladıklarında, finansal sorunlarla ilgili sıkıntı ve sorunlarına yardımcı olabilecek deneyimli kişilere yönlendirilmeleri önerilmektedir.

    • SDG 1 · Yoksulluğa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 5 · Toplumsal Cinsiyet Eşitliği
    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
    • SDG 10 · Eşitsizliklerin Azaltılması
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    The Effects of Medications Used in the Treatment of Rheumatological Diseases on Pregnancy and Fertilization: A Single-center Experience

    Şahin, Ali; Karataş, Beliz; Yalçın, İlker; Çelik, Neşe Çabuk; Pire, Gizem; Eren, Hatice Seyma; Karakaş, Burak; Kuzu, Merve Şenol; Yildirim, Merve; Özdamar, Burcu Nur

    Objective: Considering that the group of rheumatological patients generally consists of women in their reproductive period due to hormonal effects, we aimed to investigate the effects of the treatments given to prevent joint and organ damage caused by these diseases on pregnancy and fertilization. Methods: This study included 1,000 female patients who were followed up due to rheumatological diseases at the rheumatology department of the internal medicine department of our hospital between January 2014 and January 2021. The patients’ ages, rheumatological disease diagnoses, pregnancy status, abortion status, curettage status, medications used, medications used during pregnancy, pregnancy complications, infertility data were retrospectively analyzed. Results: The number of patients who became pregnant after diagnosis increased with the use of colchicine and anakinra, while it decreased with the use of methotrexate and leflunomide. It was observed that the number of abortions before diagnosis increased in the presence of antiphospholipid antibody syndrome (APS) and systemic lupus erythematosus. It was determined that the number of patients giving live births decreased in the presence of an APS diagnosis. It was determined that the number of patients who had live births with the use of colchicine and hydroxychloroquine during pregnancy increased. Conclusion: It should be considered that women of reproductive age with rheumatic diseases may desire pregnancy and may present to the clinic with either planned or unplanned pregnancies during their follow-ups, and accordingly, efforts should be made to avoid medications that could cause infertility as much as possible.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Diagnostic Effectiveness of Ischiofemoral Space and Quadratus Femoris Distance Measurements in Ischiofemoral Impingement Syndrome

    Kızılgöz, Volkan; Sunar, Mukadder; Gökgöz, Mehmet Burak; Kolak, Merve

    Objective: To ascertain whether measurements of the quadratus femoris and ischiofemoral intervals obtained on pelvic magnetic resonance imaging (MRI) examinations are useful for diagnosing ischiofemoral impingement (IFI) syndrome. Methods: MRIs of 178 patients (104 females and 74 males) were reinterpreted bilaterally for signal changes on T2-weighted sequences in the ischiofemoral space (IFS) and quadratus femoris space (QFS), indicating IFI. Receiver operating characteristic (ROC) curves were plotted for each measurement parameter, and the corresponding area under the curve (AUC) values were reported. A P value of less than 0.05 was considered to indicate a significant difference, and the results were assessed at the 95% confidence level. Results: There was no significant difference in age between females and males (P = 0.064). Radiologically, 17.7% of all participants were diagnosed with IFI. Significant differences were observed between IFS and obturator femoris space values by gender, with both values being significantly lower in women. A higher percentage of patients testing positive for IFI was observed in women compared with men. In the ROC analysis conducted according to IFS, the AUC was 0.840. The highest value of sensitivity × specificity was 21.29 mm. The sensitivity at this value was 0.676. The specificity at this value was 0.857. In the ROC analysis using QFS, the AUC was 0.856. The highest value of (sensitivity × specificity) was 16.17 mm. The sensitivity at this value was 0.765. The specificity at this value was 0.794. Conclusion: The results of the current study indicated a significant relationship between the IFS and QFS measurements and IFI. These intervals showed a significant negative correlation with age. This study also identified important cut-off values for IFS and QFS intervals that indicate IFI, with relatively high sensitivity and specificity.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele
  • ArticleAçık Erişim2026
    Investigation of Sensitivity and Specificity of Biochemical Markers for Cardiac Contusion due to Blunt Chest Trauma

    Elma, Bekir; Bilgin, Yasin; Sari, Fatih Mehmet; Emet, Mucahit; Öz, Funda

    Objective: There remains a significant need for precise biomarkers to diagnose cardiac contusion. The objective of this study is to examine the diagnostic significance of cardiac myosin-binding protein-C (cMyBP-C) in thoracic injuries, including cardiac contusion. Methods: The inclusion criteria were patients who consented to take part, were over 18 years of age, had sustained severe blunt chest injuries, were admitted within 24 hours post-injury, had their blood samples taken within the first 2 hours of admission, and had at least one of the following injuries: sternal, rib, or left scapular fractures; hemothorax, pneumothorax, pulmonary contusion, traumatic asphyxia, or pneumomediastinum. Troponin I levels ≥ 0.04 ng/mL, measured within 2 hours of admission, are considered the gold standard for diagnosing cardiac contusion. Serum troponin-I concentrations were assessed using an immunochemical technique. Serum cMyBP-C concentrations were measured using an enzyme-linked immunosorbent assay. Results: Participants included 85 patients, with 59 men (69.4%) and a mean age of 48.6 ± 20.8 years (range: 18-84 years). Among them, 18 individuals (21.2%) experienced cardiac contusion. No significant difference was observed in cMyBP-C levels between the cardiac contusion group and the other group (17.7 ± 18.6 vs. 14 ± 15.3, P = 0.328). Receiver operating characteristic analysis revealed that the discriminative performance of cMyBP-C in distinguishing contusion was not statistically significant. In this analysis, the area under the curve for cMyBP-C was 0.575 ± 0.077 (95% confidence interval, 0.425-0.726; P = 0.328), indicating poor discriminative ability and a lack of statistically significant diagnostic value for contusion. Conclusion: While cMyBP-C holds theoretical promise as a cardiomyocyte-specific biomarker, our findings suggest that its current diagnostic performance may be limited in the context of blunt cardiac contusion. Further studies with larger cohorts and refined detection methods are warranted to clarify its clinical utility.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    RDL Kalıcı Kaydıİncele