SDG 3 · Sağlık ve Kaliteli Yaşam · SDG · Erzincan Binali Yıldırım Üniversitesi

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Conference ObjectYalnız künye2026/r/ebyu/18455
Investigation of the Anticancer Efficacy of the Combination 6-Gingerol and Apigenin in Cervical Cancer Cells
Çetinkaya, B. Demir; Gözcü, S.
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ArticleAçık Erişim2026/r/ebyu/18450
Effect of education on oral antiviral use on medication adherence and quality of life in patients with chronic hepatitis B: a randomised trial
Korkmaz Binay, Sengul; Özakgül, Aylin
Background: Adherence to oral antiviral therapy is essential to reduce progression from chronic hepatitis B (CHB) to cirrhosis and hepatocellular carcinoma. Aim: To evaluate the effect of education on oral antiviral use on medication adherence and quality of life (QoL) in patients with CHB. Methods: This randomised controlled trial included 60 of 105 eligible patients with CHB. All completed the study. The intervention, delivered by the researcher, consisted of individualised education and telephone counselling tailored to patients' learning needs and focused on medication adherence. The control group received usual care. Data were collected using the MARS-5, MedTake test, LDSI, SF-12 and PLNS at baseline and 3 months. Data were analysed using SPSS 26. Results: At baseline, there were no significant differences between the groups in medication adherence and laboratory parameters (p > 0.05). Mean baseline PLNS scores were 154.43 +/- 3.61 in the control group and 162.63 +/- 9.6 in the intervention group. At 3 months, the proportion of patients achieving medication adherence above 80% was significantly higher in the intervention group (p < 0.01). The intervention group showed significant improvements in MARS-5, MedTake Test scores, SF-12 and LDSI scores, with lower HBV-DNA, ALT and AST levels (p < 0.01). Conclusion: Individualised education may improve medication adherence and QoL in patients with CHB.
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ArticleAçık Erişim2026/r/ebyu/18341
A Rare Cause of Respiratory Failure in an Alzheimer's Patient: Esophagual ForeignBody
Kantar, Yusuf
Foreign body impaction in the esophagus is a common emergency, particularly among children; however, unusual presentations in geriatric patients are rarely encountered. The clinical manifestation may vary depending on the type and location of the foreign body and the patient's underlying condition. We report the case of a 79-year-old bedridden male patient with Alzheimer's disease who presented to the emergency department with shortness of breath and audible wheezing. Initial evaluation and imaging studies revealed no acute pulmonary pathology. A lateral neck X-ray demonstrated an image consistent with a foreign body at the cervical level, which was later confirmed by computed tomography to extend along the esophagus. Under sedation with fentanyl and ketamine, the foreign body-a sock-was successfully removed using a laryngoscope and long forceps. The patient recovered uneventfully and was discharged after clinical stabilization. This case is remarkable due to the atypical presentation and the unusual nature of the ingested object. While most esophageal foreign bodies in adults are accidental or intentional, this case resulted from unconscious behavior related to Alzheimer's disease. Emergency physicians should maintain a high index of suspicion when evaluating elderly or cognitively impaired patients presenting with atypical respiratory symptoms, as early recognition and prompt intervention can be lifesaving.
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ArticleAçık Erişim2026/r/ebyu/18339
Antioxidant and Antimicrobial Activities and Phenolic Composition of Vaucheria aversa Isolated from the Tigris River (Diyarbakır, Türkiye)
Uç, Osman; Pabuçcu, Koksal
This study aims to evaluate the pharmaceutical potential of Vaucheria aversa isolated from the Tigris River through the assessment of its antioxidant capacity, antimicrobial activities, and phenolic compound composition. In this study, samples collected from benthic habitats were purified using a mechanical isolation method. The phenolic and flavonoid contents of the prepared extracts were measured by spectrophotometric methods, and their phenolic profiles were determined using LC-MS/MS analysis. Antioxidant activities were assessed using FRAP, DPPH, and ABTS assays, while antimicrobial activities were tested on E. coli, S. aureus, and C. albicans using the agar well-diffusion method. The total phenolic content of V. aversa was determined to be 64.28 f 2.11 mg GAE/g, while the flavonoid content was 15.21 f 0.89 mg QE/g. Regarding antioxidant activities, the FRAP value was 65.55 f 3.18 mg TE/g, the DPPH IC 50 value was 38.25 f 1.41 & micro;g/ml, and the ABTS IC50 value was 16.39 f 1.02 & micro;g/ml. LC-MS/MS analysis revealed that cinnamic acid and gallic acid were present at higher levels compared to other phenolic compounds. In antimicrobial assays, ethanol and methanol extracts exhibited strong inhibition zones against E. coli and C. albicans. The activity of V. aversa against Gram (-) negative bacteria and fungi was found to be particularly noteworthy compared to other Vaucheria species. Its antioxidant and antimicrobial capacities are presumed to be directly associated with its phenolic compound content. The findings of this study indicate that in order to evaluate V. aversa as a natural antioxidant and antimicrobial agent in pharmaceutical research, further compound isolation and in vivo investigations are required to elucidate its effective pharmaceutical potential in detail.
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ArticleAçık Erişim2026/r/ebyu/18312
Evaluation of Paramedic Pre-hospital's Analgesic Management of Trauma Patients
Kantar, Y.; Hayme, S.
Background:Although analgesic management is a critical priority in the guidelines for trauma patients, paramedics' prehospital administration practices vary.Objectives:This study evaluated the paramedics' practices regarding prehospital analgesia administration in trauma patients.Methods:The study was conducted in two phases. In the first phase, the records of patients 18 years and above who were brought to our hospital via ambulance were retrospectively reviewed. A total of 506 patients with trauma were included in this phase of the study. In the second phase, paramedics' practices regarding pre-hospital analgesic administration to trauma patients, such as drugs, and frequency. Data were analyzed using descriptive statistics, and are presented as mean +/- standard deviation for numerical variables and as frequency and percentage for nominal variables. Nominal variables were evaluated using the Pearson Chi-Square test.Results:According to data collected retrospectively in the first phase of the study, prehospital analgesia was administered to only 1% of the 506 patients. In the second phase of the study, when asked about the reasons for not administering prehospital analgesia, it was found that 77.5% of paramedics believed that doing so would interfere with the hospital physician's examination.Conclusion:High rates of interventions such as spinal board immobilization, cervical collar application, and appropriate splinting or dressing have been observed in trauma patients. Paramedics were also found to be quite successful in establishing intravenous access. However, the rates of fluid administration and analgesia were considerably lower compared to the literature.
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ArticleYalnız künye2026/r/ebyu/18280
Childhood traumas and criminal thinking effects on criminal behaviours: unexpected outcomes of intimate partner violence
Babacan, Hakki Halil; Gölge, Zeynep Belma
This study explores the relationship between violent and non-violent criminal behaviour and various factors among university students. The factors include criminal thinking styles, childhood traumas, male gender, drug use, harming animals, frequent fighting in childhood and the level of disciplinary punishment received. The study involved 854 university students from 96 universities, all of whom are over 18 and have not received any judicial punishment. The analysis revealed that higher levels of childhood traumas, criminal thinking, drug use and disciplinary punishments in school correlate with an increase in both violent and non-violent criminal behaviours. Additionally, males, those who harmed animals and those who fought frequently in childhood are more likely to exhibit these behaviours. Notably, intimate partner violence was uniquely linked to power orientation, entitlement, and emotional and sexual abuse. The research highlights the complex interactions between individual psychological factors and childhood experiences in leading to criminal behaviours and emphasizes the need for more studies focusing on societal and cultural risk factors for intimate partner violence.
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ArticleAçık Erişim2026/r/ebyu/18240
Effects of early shoulder exercise on functional recovery after cardiac implantable electronic device implantation: A 3-year randomized cohort follow-up
Cosgun, Muharrem Said; Cosgun, Cansu
Background. Shoulder dysfunction after cardiac implantable electronic device (CIED) implantation may impair upper-extremity function and quality of life (QoL). Although a prior randomized trial demonstrated short-term benefits of early postoperative exercises, long-term outcomes remain unclear. Aim. To evaluate the 3-year efficacy and safety of an early postoperative shoulder exercise protocol after CIED implantation. Methods. Of 92 patients randomized in the original trial, 82 completed the 3-year follow-up. Participants had completed a 6-week intervention consisting of pendulum exercises (PE), stretching & strengthening exercises (SSE) or standard care, without further structured exercise. Outcomes included Visual Analog Scale (VAS) pain scores, grip strength, shoulder flexion and abduction range of motion (ROM), Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), and the Physical and Mental Component Summary scores (PCS and MCS) of the 36-Item Short-Form Survey (SF-36). Lead-related complications were also assessed. Results. VAS and SF-36 MCS scores were comparable across groups. However, compared with standard care, both exercise groups maintained superior outcomes at 3 years for grip strength (PE: +9.0 kgf; SSE: +9.0 kgf), shoulder flexion ROM (PE: +10.0 degrees; SSE: +11.0 degrees), shoulder abduction ROM (PE: +7.0 degrees; SSE: +7.0 degrees), QuickDASH (PE: -5.0 points; SSE: -6.0 points), and SF-36 PCS (PE: +9.0 points; SSE: +10.0 points) (all P < 0.05). No lead-related complications occurred during follow-up. Conclusion. Early postoperative shoulder exercise after CIED implantation provides sustained improvements in shoulder function and physical QoL without compromising lead safety.
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ArticleAçık Erişim2026/r/ebyu/11581
Impact of Intraperitoneal Drain Placement on Postoperative Pain After Total Laparoscopic Hysterectomy
Küçükatalay, Özge; Kantarcı, Sercan; Dağlı, Uğurcan; Kanmaz, Ahkam Göksel; Töz, Emrah; Ileri, Alper; Inan, Abdurrahman Hamdi
Introduction: Total laparoscopic hysterectomy (TLH) is widely performed for benign gynecologic conditions; however, postoperative pain particularly shoulder pain related to residual intraperitoneal CO2 remains a clinical concern. This study aimed to evaluate whether drain placement reduces postoperative pain and analgesic requirements after benign TLH. Methods: In this prospective observational study, 129 women undergoing TLH were included; 86 received an intraperitoneal drain and 43 did not. Drain placement was based on the surgeon’s intraoperative judgment. To ensure a homogeneous low-complexity cohort, cases with complications or deviations from standard TLH were excluded. Postoperative shoulder, chest, and abdominal pain were assessed using a 10-point visual analog scale at 6, 12, and 24 hours. Analgesic use and early postoperative outcomes were also recorded. Results: Baseline demographic and perioperative characteristics were comparable between groups. Multivariable regression analysis showed that drain placement was independently associated with higher shoulder pain at 6 and 12 hours (p = 0.015 and p < 0.001) and higher chest pain at 6 hours (p = 0.039). Abdominal pain was higher at 6 hours but lower at 24 hours in the drain group (p = 0.039 and p = 0.032). Despite these time-dependent differences, overall postoperative analgesic consumption during the first 2 days was significantly higher in patients with drains (p < 0.05). Conclusion: Intraperitoneal drain placement after benign TLH was associated with increased early postoperative pain and did not reduce overall analgesic consumption. Routine drain use cannot be recommended, and selective placement should be reserved for specific clinical situations.
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ArticleAçık Erişim2026/r/ebyu/11523
Neuroendocrine effects of exogenous adropin administration on the hypothalamic pituitary testicular axis in male rats
Eraslan, Ersen; Tanyeli, Ayhan; Güler, Mustafa Can; Özbek Bilgin, Aslı; Ekinci Akdemir, Fazile Nur; Polat, Elif; Çomakli, Selim; Kurt, Nezahat; Bal Taştan, Tuğba
Background/aim: Obesity impairs male fertility through metabolic dysfunction, oxidative stress, and disruption of the hypothalamic– pituitary–testicular (HPT) axis. Adropin (ADR), a peptide hormone whose circulating levels are reduced in obesity, plays emerging roles in metabolic homeostasis; however, its involvement in reproductive endocrine regulation remains unclear. The present study was conducted in healthy, nonobese male rats and aimed to investigate the neuroendocrine and testicular effects of exogenous ADR administration, focusing on circulating reproductive hormones, hypothalamic regulatory peptides, and testicular antioxidant pathways. Materials and methods: Thirty-two male Wistar rats were randomized into control, sham, low-dose ADR (4 μg/kg/day), and high-dose ADR (40 μg/kg/day) groups and treated for 10 days. An enzyme-linked immunosorbent assay (ELISA) was used to measure circulating gonadotropins, testosterone, inhibin B, and activin A. Hypothalamic gonadotropin-releasing hormone (GnRH) and kisspeptin expression, and testicular superoxide dismutase 1 (SOD1) localization were assessed by immunohistochemistry. Brain and testis morphology were examined histologically. Results: High-dose ADR administration was associated with increased hypothalamic GnRH and kisspeptin expression, accompanied by reduced circulating LH levels, while FSH concentrations remained unchanged. Testosterone and inhibin B levels were higher, whereas activin A levels were lower, in the high-dose ADR group compared with controls. ADR administration was also associated with enhanced testicular SOD1 immunoreactivity and dose-dependent reductions in body weight. No overt histopathological alterations were observed in the cerebral cortex or testicular tissue. Conclusion: In healthy, nonobese male rats, exogenous ADR administration was associated with changes in central neuroendocrine markers and testicular antioxidant responses without overt histopathological alterations. These findings do not demonstrate improvements in fertility but suggest that ADR may be involved in pathways linking metabolic signals with reproductive endocrine regulation. The potential relevance of these observations to obesity-associated male reproductive dysfunction remains hypothesis-generating and requires confirmation in appropriate disease models and functional reproductive studies.
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ArticleYayıncıda açık erişim2026/r/ebyu/11522
Investigation of the Effect of Akkermansia muciniphila Muc T (ATCC BAA-835) on TLR4/NF-Kappa B/NLRP2 Signaling Pathway and Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome in Rats
Ucar, Mahmut; Celebi, Demet; Celebi, Ozgur; Baser, Sumeyye; Guler, Mustafa Can; Tanyeli, Ayhan; Kılıclıoglu, Metin; Yıldırım, Serkan
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder associated with gut microbiota dysbiosis, intestinal barrier dysfunction, and low-grade inflammation. This study aimed to evaluate the effects of Akkermansia muciniphila Muc T (ATCC BAA-835) on gut microbiota composition, intestinal barrier integrity, and TLR4/NF-κB/NLRP2-mediated inflammatory signaling in a stress-induced rat model of IBS-D. IBS-D was induced in rats using combined chronic and acute stress paradigms. Animals received A. muciniphila supplementation during the experimental period. Serum inflammatory cytokines and tight junction–related proteins were quantified by ELISA. Protein expression levels of TLR4, NF-κB, and NLRP2 were assessed by Western blotting. Gut microbiota composition was analyzed using 16 S rRNA gene sequencing of fecal samples. Histopathological and immunofluorescence analyses were performed to assess tissue inflammation and cellular damage. IBS-D rats exhibited increased inflammatory cytokine levels, impaired tight junction protein expression, activation of the TLR4/NF-κB/NLRP2 pathway, and significant alterations in gut microbiota diversity. A. muciniphila supplementation significantly attenuated inflammatory responses, restored intestinal barrier–associated proteins, and suppressed inflammatory signaling. Microbiota analysis revealed partial correction of dysbiosis, including increased abundance of beneficial taxa such as Faecalibacterium prausnitzii. A. muciniphila alleviates IBS-D–associated intestinal inflammation and barrier dysfunction by modulating gut microbiota composition and inflammatory signaling pathways, supporting its potential as a microbiota-based therapeutic strategy for IBS-D.
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ArticleYalnız künye2026/r/ebyu/11502
Association between environmental literacy and carbon footprint awareness among future healthcare professionals
Aydın Kahraman, Handan; Bozcu Kartal, Ebru
Climate change poses significant threats to global health, necessitating a healthcare workforce equipped to handle these challenges. This study aimed to evaluate the level of environmental literacy among nursing students and to determine its predictive impact on their carbon footprint awareness. This descriptive, cross-sectional study was conducted with 402 undergraduate nursing students at a public university in eastern Türkiye. Data were collected using a Personal Information Form, the Environmental Literacy Scale for Adults (ELSA) to assess environmental consciousness, concern, and awareness, and the Carbon Footprint Awareness Scale (CFAS) to measure climate-conscious daily behaviors. Participants demonstrated high environmental literacy (mean ELSA score: 79.01 ± 10.35) and substantial awareness (mean CFAS score: 68.19 ± 9.69). A strong, positive correlation existed between environmental literacy and carbon footprint awareness (r = 0.694; p < 0.001). Regression analysis indicated that environmental literacy is a significant predictor, explaining 48% of the variance in carbon footprint awareness (R2=0.480; F = 371.608; p < 0.001). Environmental literacy strongly predicts carbon footprint awareness. Integrating comprehensive planetary health and environmental literacy strategies into nursing curricula is essential to foster a generation of nurses conscious of their carbon footprint and capable of leading sustainable healthcare practices.
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ArticleYayıncıda açık erişim2026/r/ebyu/11495
p-Coumaric Acid Attenuates Lead Acetate-induced Neurotoxicity in Rats by Improving Behavioral Dysfunction and Suppressing Oxidative Stress, Neuroinflammation, Apoptosis, and Plasticity-related Molecular Alterations
Karaarslan, Tuba; Bolat, Merve; Bolat, İsmail; Orhan, Betul; Senocak, Esra Aktas; Tekin, Samet; Lacin, Burak Batuhan; Golgeli, Ayse; Atasever, Aslıhan
This study evaluated the neuroprotective effects of p-coumaric acid (p-CA) against lead acetate (PbAc)-induced neurotoxicity in rats by focusing on oxidative stress, neuroinflammation, apoptosis, and neuronal plasticity. 35 male rats were randomly assigned to five groups: Control, p-CA (100 mg/kg), PbAc (30 mg/kg), PbAc + p-CA (50 mg/kg), and PbAc + p-CA (100 mg/kg). Treatments were administered orally for 14 days. Behavioral performance was assessed using the open field test (OFT) and elevated plus maze (EPM). Biochemical analyses of brain tissue included the measurement of MDA, GSH, SOD, CAT, and GPx levels. Western blotting was performed to determine the protein expression levels of inflammatory, glial, and synaptic markers, including NF-κB, IL-1β, IL-6, TNF-α, Iba-1, GFAP, PSD-95, and AChE. Quantitative real-time PCR was used to assess the mRNA expression levels of Bax, Bcl-2, Caspase-3, MAP-2, NeuN, and GAP-43. Histological evaluations included hematoxylin-eosin (H&E) staining for neuronal morphology, immunohistochemistry (IHC) for 8-OHdG, GABA, and GFAP, and immunofluorescence (IF) staining for BDNF expression. PbAc exposure caused marked oxidative damage, neuroinflammatory activation, enhanced apoptotic signaling, and impaired neuronal plasticity, accompanied by reduced antioxidant defenses and altered expression of plasticity-related markers. Co-treatment with p-CA significantly ameliorated these biochemical, molecular, and histopathological alterations in a dose-dependent manner. The 100 mg/kg dose of p-CA showed the strongest neuroprotective effect, restoring many parameters close to control levels. Overall, these findings suggest that p-coumaric acid exerts neuroprotective effects against PbAc-induced brain injury by attenuating oxidative stress, neuroinflammation, and apoptosis while supporting neuronal plasticity. Therefore, p-CA may represent a promising natural compound for further investigation in heavy metal-induced neurotoxicity models. However, further studies are required to clarify the upstream molecular signaling pathways involved and to determine whether these protective effects can be maintained under long-term exposure conditions.
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ArticleYalnız künye2026/r/ebyu/11491
Air quality index modeling using ensemble and data-intelligence modeling
Pande, Chaitanya Baliram; Katipoğlu, Okan Mert; Radwan, Neyara; Sidek, Lariyah Mohd; Pal, Subodh Chandra; Yaseen, Zaher Mundher; Ali, Tarig; Chakrabortty, Rabin; Refadah, Samyah Salem; Khan, Mohd Yawar Ali
Urban population growths, expansion of the industrial economy, burning stubble, and other major sources have significantly contributed to the increasing levels of air pollution in urban areas. Therefore, accurate prediction of the Air Quality Index (AQI) is essential for effective monitoring and planning within cities. In this research, an ensemble machine learning (ML) called Gradient Boosting (GB) model with 5- and 10-folds’ cross-validation was developed to achieve more precise and operative prediction outcomes based on important air quality related input variables. The results demonstrated that the suggested hybrid model attained the best accuracy in comparison with other benchmark ML models for predicting AQI values of Delhi city. Statistically, GB model reported second best model based on statistical metrics (R2 = 0.96, R = 0.98, RMSE = 23.03, MSE = 530.71, MAE = 15.16 and MARE = 11.96). Whereas Light Gradient Boosting Machine (LightGBM) model third best accuracy reported (R2 = 0.96, R = 0.98, RMSE = 23.21, MSE = 538.74, MAE = 14.68, and MARE = 11.33). The AQI prediction values are presented as spatial thematic maps for better understanding, highlighting city areas with high AQI levels to support air quality planning. The daily AQI prediction maps were prepared using various ML models. Further, the current research forecasted five days of AQI values and compared with the observed values. The results of five-day forecasting of GB model again indicated the best match with observed data of AQI values. Finally, forecasting accuracy results of GB (Boosting) models was attained 90% match with the observed values of AQI as compared with hybrid model. In conclusion, the reported results provided better understanding of AQI modeling for values and classes of spatial maps.
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ArticleAçık Erişim2026/r/ebyu/11458
Phytochemical profiling of Artemisia absinthium essential oils from different regions of Türkiye and preliminary evaluation of their antibacterial and honeybee locomotor effects
PORTAKAL, Pınar; TUFEKCI, Ali Rıza; ARSLAN, Okan Can; AKŞIT, Hüseyin; GÖÇERI, Ali; KÜRSAT, Murat
This study aimed to determine the phytochemical composition of essential oils obtained from Artemisia absinthium collected in Sivas (AAS), Erzincan (AAE) and Hakkari (AAH) and to evaluate their effects on honeybee locomotor activity. The chemical composition of the essential oils was analyzed by GC–MS, revealing notable regional differences. Chamazulene was identified as the predominant compound in all samples, with the highest concentration in AAH (64.6%), while AAE was characterized by a high β-thujone content (18.3%). Locomotor activity assays showed no significant differences between control and treated groups over a 24-hour period (H (3) = 4.270, p=0.234; F (3,121)=0.867, p=0.460), indicating no detectable acute locomotor alterations under the tested conditions. The antibacterial activity of the essential oils was evaluated using the disc diffusion method against both Gram-positive and Gram-negative bacteria. Antibacterial effects varied depending on the oils' geographical origin and chemical composition. AAE and AAS essential oils showed comparatively larger inhibition zones, particularly against Staphylococcus aureus and Bacillus cereus, whereas AAH showed selective activity against Pseudomonas aeruginosa. No inhibition of Listeria monocytogenes was observed with any of the tested oils. Overall, the oils' antibacterial activity was moderate and selective compared with the positive control, imipenem. These findings suggest that regional variation significantly influences the chemical composition and biological activity of A. absinthium essential oils. Furthermore, the tested oils did not produce detectable acute locomotor alterations in honeybees under the conditions tested. These findings provide preliminary insight into the relationship between regional phytochemical variability and the biological properties of A. absinthium essential oils.
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ArticleYalnız künye2026/r/ebyu/11446
Development and characterization of olopatadine and verbascoside-loaded thermoresponsive in situ gels for ocular drug delivery: a factorial design approach for allergic conjunctivitis
Polat, Heybet Kerem; Çopur, Tuğba; Pezik, Esra; Turanlı, Yasin; Karakuyu, Nasıf Fatih; Köngül, Esra; Ünal, Sedat; Gözcü, Sefa; Sarman, Emine
Objective: Allergic conjunctivitis is one of the most prevalent conditions affecting the eyes, and various medications are used in its treatment. In this study, olopatadine and verbascoside were used in combination. Methods: A factorial design was employed to evaluate the effects of Poloxamer 407 and sodium alginate. The impact of polymer concentration on parameters such as viscosity, gelation time, mucoadhesion, pH, and gelation temperature–considered indicators of ideal formulations–was assessed. Results: The optimal formulation, determined through the factorial design, included 0.5% sodium alginate and 20% poloxamer 407. The obtained values were viscosity at 25 °C = 7451.8 cP, viscosity at 35 °C = 11367.3 cP, pH = 7.12, gelation temperature = 30 °C, gelation time = 52 s, and mucoadhesion = 0.301 N. Cytotoxicity tests on ARPE-19 and L929 cells, along with irritation studies, indicated acceptable safety profiles. In vitro release tests demonstrated an initial burst release of verbascoside and olopatadine during the first 2 h, followed by a controlled release over the subsequent 8 h. Mathematical analysis of the release kinetics revealed a good fit with the Weibull model. No adverse effects were observed in rats during Draize’s in vivo test. Conclusions: Consequently, the drug-loaded in situ gel formulation may be a promising option for treating allergic conjunctivitis.
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ArticleYalnız künye2026/r/ebyu/11436
The Relationship Between Parents' E-Health Literacy and Attitudes Toward Childhood Vaccination: A Descriptive-Correlational Study
Aras Doğan, Şenay; Kasımoğlu, Necla; Oluç, Tuğba
Objective: This study aimed to examine the relationship between parents' e-health literacy and attitudes toward childhood vaccination. Design: A descriptive-correlational study. Sample: The study included 396 parents of children aged 0 to 72 months, recruited between May and December 2022. Measurements: Data were collected using the Demographic Information Form, the E-Health Literacy Scale (E-HLS), and the Caregiver Vaccination Attitudes Scale (CVAS). Analyses were performed using SPSS (version 24). Results: The mean age of the parents was 30.13 ± 5.22 years. E-HLS scores differed significantly by education level (F = 6.914, p < 0.001, η2 = 0.034), with higher scores among university-educated parents (29.72 ± 5.99) compared to those with secondary (26.86 ± 6.64) or primary education (27.48 ± 5.98). Economic status also showed significant differences in E-HLS (KW = 6.982, p = 0.03, ε2 = 0.012); parents with good economic status (29.54 ± 5.89) scored higher than those with poor status (26.35 ± 4.32). A statistically significant but weak positive correlation was found between CVAS and E-HLS (r = 0.172, p < 0.001), indicating a small effect size. Conclusions: This study showed that parents with higher e-health literacy tend to have more positive attitudes toward childhood vaccination. However, the relationship between these two variables was weak, suggesting only a limited association between e-health literacy and vaccination attitudes. In addition, parents with higher education and better economic status had higher e-health literacy scores. Due to the weak correlation observed, it is important for nurses to understand that increasing e-health literacy alone is unlikely to produce significant improvements in parental vaccination attitudes. Despite the weak correlation, these results may help guide future research exploring the broader context of vaccine attitudes among parents.
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ArticleAçık Erişim2026/r/ebyu/11434
Determination of antimicrobial activity of Niaouli Essential Oil (Melaleuca quinquenervia) by two different methods; [Nioli Esansiyel Yağının (Melaleuca quinquenervia) antimikrobiyal aktivitesinin iki farklı yöntemle belirlenmesi]
Akyüz, Sümeyye
Objective: This study aimed to investigate the antimicrobial activity of Niaouli Essential Oil (Melaleuca quinquenervia), a commercially available oil known for its antiseptic, antimicrobial, antioxidant, anti-inflammatory, and antiprotozoal properties due to its bioactive constituents, against eight different standard bacterial strains, two standard yeast strains, and one clinical Candida isolate. Methods: The antimicrobial activity of niaouli essential oil against the isolates was evaluated using the disk diffusion and broth microdilution methods in accordance with EUCAST and CLSI guidelines. Ten of the microbial strains were American Type Culture Collection (ATCC) strains, and one was a clinical Candida auris isolate. The isolates were obtained from the strain collection of our university. Results: In this study, the disk diffusion method revealed that niaouli essential oil (Melaleuca quinquenervia) was most effective against Staphylococcus aureus (20 ± 0.0 mm) and Streptococcus pneumoniae (17.3 ± 0.57 mm) among the bacterial strains, and against Candida albicans (20.6 ± 0.57 mm) among the fungal strains. The Candida auris isolate exhibited an inhibition zone of 16.0 ± 1.0 mm. The lowest MIC values determined by the broth microdilution method were 62.5 μg/mL for both S. aureus and C. albicans. Among the Gram-negative isolates, Klebsiella pneumoniae was the most susceptible (125 μg/mL), whereas Pseudomonas aeruginosa, Salmonella enteritidis, and Enterococcus faecalis were the least susceptible (>250 μg/mL). The MIC value for C. auris was determined to be 250 μg/mL, which is one dilution higher than the positive control (fluconazole: 125 μg/mL). Conclusion: Niaouli essential oil demonstrated antimicrobial activity against standard microbial strains, with varying levels of antibacterial and antifungal effects. According to both methods used, it was more effective against Gram-positive bacteria and fungi than Gram-negative bacteria. While it was particularly effective against Candida albicans among the yeasts, it also exhibited antimicrobial activity against the increasingly important Candida auris strain. Due to the increasing resistance to antibacterial and antifungal agents, further studies investigating alternative treatment options are needed.
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ArticleAçık Erişim2026/r/ebyu/11423
The Effect of Nursing Training Given to Parents of Asthmatic Children on Home Design Awareness and the Child’s Quality of Life: A Quasi-Experimental Study
Özdemir, Selen; Bilgin, Sonay
Background: This study aimed to examine how nursing training provided to parents of asthmatic children affects the child’s quality of life by increasing their awareness of home environment arrangements. Methods: This study, which was conducted using a single-group pre-test post-test design, was conducted in a Training and Study Hospital in a province of Turkey. The study sample consisted of 35 asthmatic children and their parents who were hospitalized in the pediatrics polyclinic and inpatient ward during the pandemic period between March and July 2021. The data were collected with the “Asthmatic Child Information Form,” “Pediatric Ashtma Quality of Life Questionnaire,” and “Home Design Awareness Scale in Children with Asthma.” Frequency, percentage, mean, SD, paired samples t-test, Wilcoxon signed-rank test, independent t-test, and Mann–Whitney U-test were used to evaluate the data. Results: The asthmatic children included in the study had sub-dimension and total score averages of the Pediatric Asthma Quality of Life Questionnaire and the published Home Design Awareness Scale in Children with Asthma as pre-test-post-test, and the post-test score averages of all sub-terms after the training (P < .05). Conclusion: It has been observed that the parents’ home design awareness increases, and the children’s quality of life increases with the nursing training given to the parents of asthmatic children to protect them from indoor factors that trigger asthma attacks in their children.
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ArticleAçık Erişim2026/r/ebyu/11416
Formulation, Characterization, and Preliminary In Vitro Evaluation of Letrozole Incorporated Eudragit® RS 100 Nanoparticles Using HepG2 Cells
Polat, Muhammet Ali; Aykaç, Kadir; Cantürk, Zerrin; Başaran, Ebru
Introduction/Objective: Letrozole (LTZ)-loaded polymeric nanoparticles (PNPs) were formulated with Eudragit® RS100 to investigate their potential as a preliminary drug delivery system for hepatocellular carcinoma (HCC). Methods: Nanoparticles were prepared using the spray-drying technique with a Büchi B-90 Nano Spray Dryer and characterized in terms of morphology, particle size, polydispersity index (PDI), zeta potential, drug loading efficiency, thermal and structural characteristics, in vitro release behavior, and preliminary cytotoxicity. Results: Scanning electron microscopy (SEM) analysis demonstrated the formation of predominantly spherical particles with relatively smooth surfaces. The prepared nanoparticles exhibited initial particle sizes ranging between 253 nm and 425 nm, with PDI values of 0.3–0.4 and positive zeta potential values between 36 and 48 mV. Encapsulation efficiency (EE%) and drug loading (DL%) values were determined as 47.9%–56.9% and 9.1%–18.6%, respectively. Thermal and structural analyses indicated the molecular dispersion of LTZ within the polymeric matrix. In vitro release studies conducted at pH 7.4 demonstrated an initial burst release, followed by a sustained drug release profile over 24 h, with cumulative drug release reaching almost 80%. The preliminary cytotoxicity of the formulations was evaluated using the methylthiazolyl-diphenyl-tetrazolium bromide (MTT) assay on human hepatocellular carcinoma (HepG2) and healthy human dermal fibroblast (BJ) cell lines. Free LTZ demonstrated an IC50 value of 142.76 μg/mL against HepG2 cells, whereas the optimized nanoparticle formulation exhibited an IC50 value higher than 121.85 μg/mL. Discussion: The obtained results confirmed the successful development of LTZ-loaded polymeric nanoparticles with suitable physicochemical properties, efficient drug encapsulation, and sustained release behavior. The positive surface charge and nanoscale size may support formulation stability. Furthermore, the nanoparticles preserved the cytotoxic activity of LTZ, indicating their potential as an effective drug delivery system. Conclusion: Overall, the findings suggest that the developed nanoparticles constitute a promising drug delivery system for further investigation in HCC-related therapy. However, additional mechanistic studies and in vivo evaluations are required to comprehensively assess their true therapeutic potential. 2026, The Author(s).
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ArticleYalnız künye2026/r/ebyu/11362
The protective efficacy of rosmarinic acid in radiotherapy-induced ototoxicity
Altıparmak, Serkan; Özcan, İbrahim; Kaya, Altan; Aytekin, Aynur; Karaman, Hatice
Background: Radiotherapy-induced ototoxicity remains a significant clinical problem, and potential protective agents such as rosmarinic acid have gained increasing research interest. Objectives: This study investigated the effectiveness of systemic and local rosmarinic acid administration in radiotherapy-induced ototoxicity using the auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE) test, and histopathological methods. Material and methods: Sixty rats were included in the study. Seven groups were created, including control, radiotherapy-only, and combinations of radiotherapy with intratympanic or intraperitoneal rosmarinic acid, as well as a radiotherapy plus intratympanic saline group. ABR and DPOAE measurements were performed with all animals initially and at the end of the third week. The temporal bones of the decapitated rats were also fixed in formalin for histopathological measurements. Results: ABR thresholds increased significantly in the radiotherapy–only group (from 22.8 ± 3.1 to 45.4 ± 3.6 dB, p = 0.004) and the radiotherapy plus intratympanic saline group (from 24.6 ± 3.1 to 47.1 ± 3.6 dB, p = 0.005), while remaining stable in the other groups (p > 0.05). Correspondingly, DPOAE values decreased and histopathological damage scores were markedly higher in these two groups. Conclusions and significance: Rosmarinic acid protects against radiotherapy-induced ototoxicity when applied both systemically and locally, as confirmed by histopathological examination and objective audiological methods.
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