SDG 3 · Sağlık ve Kaliteli Yaşam · SDG · Erzincan Binali Yıldırım Üniversitesi

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ArticleAçık Erişim2026/r/ebyu/19037
The Relationship Between Allergic Reactions and Serum Erythropoietin Levels: A New Biomarker Candidate in Allergic Reactions
Bilgin, Yasin; Sari, Fatih Mehmet; Emet, Mucahit; Sari, Haticetul Kubra
Objective: This study aimed to compare serum erythropoietin (EPO) levels in patients admitted to the emergency department with allergic reactions who were clinically diagnosed with urticaria, angioedema, or anaphylaxis, and to evaluate the diagnostic value of EPO as a potential biomarker. Methods: The study was conducted prospectively in the Emergency Department of Atatürk University between 2013 and 2016. A total of 156 patients diagnosed with urticaria, angioedema, or anaphylaxis were included. Serum EPO levels from blood samples taken at admission were analyzed using the enzyme-linked immunosorbent assay method. Relationships between vital signs, clinical symptoms, and EPO levels were statistically evaluated. Results: No significant difference in serum EPO levels was observed among the urticaria (41.7%), angioedema (35.9%), and anaphylaxis (24.4%) groups (P = 0.799). However, patients with uvular edema had significantly higher EPO levels (6.5 ± 1.6 vs. 6.0 ± 1.7 mIU/mL; P = 0.027). In the anaphylaxis group, oxygen saturation and blood pressure were significantly lower, whereas pulse rate and respiratory rate were significantly higher. Conclusion: EPO levels alone are not sufficient for differential diagnosis of acute allergic reactions. However, when assessed alongside specific symptoms, such as uvular edema, EPO may reflect the severity of the inflammatory response and serve as a potential biomarker. Multicenter studies including tissue-level analyses are needed to better understand the role of EPO in allergic inflammation.
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ArticleAçık Erişim2026/r/ebyu/19036
Non-Motor Symptoms in Gabapentin Users: A Clinical Evaluation
Tanoglu, Ceyda; Ersoy, Alevtina
Objective: Gabapentin is widely used for neuropathic pain, epilepsy, and other indications; however, its non-motor side effects remain understudied. This prospective, cross-sectional observational study aimed to evaluate non-motor symptoms in gabapentin users, assessed with the Non-Motor Symptom Scale (NMSS). Methods: The Turkish version of the NMSS was administered once to 105 patients who had been receiving gabapentin for at least 120 days and to 107 demographically matched healthy controls at our Non-Motor Symptom Scale (NMSS) between January and December 2022. Exclusion criteria included neurodegenerative diseases, diabetes, psychiatric disorders, and thyroid dysfunction. Group comparisons were performed using independent samples t-tests for continuous variables and chi-square or Fisher’s exact tests for categorical data. Results: Gabapentin users had significantly higher total NMSS scores than controls (11.6 ± 5.56 vs. 6.03 ± 4.28, P < 0.001). Symptoms such as salivation, constipation, urgency, nocturia, pain, memory impairment, depression, anxiety, sexual dysfunction, orthostatic hypotension, daytime sleepiness, and leg edema were reported more frequently in the gabapentin group (P < 0.05). Conclusion: Gabapentin use was associated with a higher frequency of non-motor symptoms, as assessed by the NMSS. This study suggests that the NMSS may serve as a structured tool for the systematic screening of non-motor symptoms in patients receiving gabapentin. Prospective studies with indication-matched controls and validated assessment tools are warranted to confirm these associations.
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ArticleAçık Erişim2026/r/ebyu/19031
Predicting Breast Cancer Biomarker Expression with Diffusion-Weighted Magnetic Resonance Imaging
Oztepe, Muhammet Fırat; Memis, Kemal Bugra; Çelik, Ayşe Sena
Objective: To evaluate the diagnostic performance of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) values in differentiating benign and malignant breast lesions, and to investigate correlations between ADC values and immunohistochemical (IHC) biomarkers (estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67) as well as axillary lymph node status. Methods: This retrospective study included 148 female patients (159 breast lesions) who underwent preoperative breast magnetic resonance imaging (MRI) between January 2022 and December 2024. DWI was performed using b values of 0 and 1000 s/mm2, and mean ADC values were calculated from regions of interest placed within solid tumor areas. Histopathological and IHC analyses were used to classify lesions and molecular subtypes. Results: Among the 159 lesions, 56 (35.2%) were malignant and 103 (64.8%) were benign. Malignant lesions exhibited significantly lower ADC values than benign ones (0.92 × 10-3 mm2/s vs. 1.66 × 10-3 mm2/s). The optimal ADC cut-off for malignancy was 1.24 × 10-3 mm2/s, yielding 95.2% sensitivity and 89.1% specificity. Hormone receptor-positive tumors and lesions with high Ki-67 index showed lower ADC values. No significant correlation was found between ADC and human epidermal growth factor receptor 2 status. Triple-negative breast cancers demonstrated the highest ADC values among subtypes. ADC values of metastatic axillary lymph nodes were significantly lower than those of contralateral benign nodes (0.78 × 10-3 vs. 1.82 × 10-3 mm2/s). Conclusion: ADC values are effective in distinguishing malignant from benign breast lesions and provide non-invasive insights into tumor biology. Lower ADC values correlate with malignancy, hormone receptor positivity, proliferative activity, and metastatic nodal involvement. DWI is a reliable, non-contrast imaging biomarker that may enhance personalized evaluation of breast cancer.
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ArticleAçık Erişim2026/r/ebyu/19025
The Relationship Between Non-alcoholic Fatty Liver Disease and Epicardial Adipose Tissue Thickness, Carotid Intima Media Thickness, and Aortic Propagation Velocity
Aydin, Sonay; Ozcicek, Fatih; Hayme, Serhat; Coşgun, Muharrem Said; Ozturk, Ersin; Öztürk, Gülay Kızılgün
Objective: Cardiovascular disease is prevalent among individuals diagnosed with non-alcoholic fatty liver disease (NAFLD). Epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), and aortic propagation velocity (APV) are associated with atherosclerosis and cardiovascular disease (CVD). The aim of this study is to determine whether NAFLD is associated with EAT, CIMT, and APV. Methods: Individuals aged ≥18 and <65 years who presented for routine follow-up were included. The study population comprised 75 healthy controls (40 females, 35 males) and 141 patients with NAFLD (68 females, 73 males). Epicardial adipose tissue thickness, carotid intima-media thickness, and aortic propagation velocity were evaluated using transthoracic echocardiography in patients who were diagnosed with hepatosteatosis by ultrasound during routine check-ups at the internal medicine clinic. Results: NAFLD was positively associated with epicardial adipose tissue thickness and carotid intima–media thickness, and negatively associated with aortic propagation velocity. Patients with NAFLD had significantly higher EAT and CIMT values and lower APV values than controls. Logistic regression analysis identified body mass index (BMI) and EAT as independent predictors of hepatosteatosis. Each unit increase in BMI was associated with a 1.29-fold increase in the risk of hepatosteatosis, whereas each unit increase in EAT was associated with a 5.49-fold increase. Conclusion: Given the established associations of CIMT, APV, and EAT with atherosclerosis and cardiovascular disease, assessment of patients with NAFLD using these noninvasive parameters may help identify subclinical cardiovascular risk.
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ArticleAçık Erişim2026/r/ebyu/19024
The impact of perceived social support on maternal–infant bonding in the postpartum period
Bulut, Hacer Kobya; Calik, Kiymet Yesilcicek; Daştan Yılmaz, Ayşe
The study aimed to assess whether mothers’ perceptions of social support influence the quality of maternal–infant bonding after childbirth. A descriptive and correlational design was employed. The study was conducted between June and December 2024 with mothers of infants aged 1–4 months who attended the obstetrics, gynecology, and pediatrics outpatient clinics of Erzincan Binali Yıldırım University (EBYU) Mengücek Gazi Training and Research Hospital. The sample size was calculated as 471 using Epi Info with a 5% margin of error and 97% confidence level; the study was completed with 505 mothers. Data were collected through face-to-face interviews using the Descriptive Information Form, the Multidimensional Scale of Perceived Social Support (MSPSS), and the Maternal Attachment Inventory (MAI). The participants’ mean age was 30.04 ± 5.67 years, and 60.4% were between 26 and 34 years old. Nearly half had completed high school (49.5%), most lived in nuclear families (88.3%), the majority were housewives (81.8%), and most perceived their income level as moderate (81.6%). A positive and statistically significant correlation was found between total MSPSS and MAI scores (r=0.289, p<0.001). At the subscale level, the strongest correlation was observed between “significant other” support and bonding (r=0.311, p<0.001), followed by family (r=0.242, p<0.001) and friends (r=0.187, p<0.001). However, regression analyses including each subscale and the total MSPSS score independently revealed no significant predictive power for maternal bonding (t=0.777– 1.101, all p>0.05). Perceived social support has a positive relationship with maternal–infant bonding in the postpartum phase. However, in univariate models, its explanatory power is limited. These findings underscore the importance of strengthening partner and family support and integrating systematic social support screening into postpartum care practices.
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ArticleAçık Erişim2026/r/ebyu/19021
The Impact of Joint Position Sense and Hand–Eye Coordination on Defensive Performance: A Study of Elite Adolescent Taekwondo Athletes
Özkara, Abdullah Bora; Senocak, Emre; Aydemir, Burakhan; Yılmaz, Duygu Sevinç; Kırkbir, Fatih
In this study examining the effects of joint position sense, reaction time, and hand–eye coordination on upper-extremity blocking performance in adolescent taekwondo athletes, 11 licensed athletes from the Trabzon Metropolitan Municipality Sports Club volunteered to participate. First, measurements of hand–eye coordination, joint position sense, and reaction time were obtained. Then, a competition simulation was conducted in which participants defended against a sequence of 20 attacks; the number of successful blocks was recorded on video. The video recordings were reviewed and scored by coaches with at least 10 years of experience. According to the Pearson correlation analyses, there was a strong positive association between the number of successful upper-extremity blocks and reaction time (r = 0.64, p = 0.03), and a strong negative association between joint position sense and block count (r = −0.61, p = 0.04). No relationship was found between hand–eye coordination and block count. Multiple regression results showed that joint position sense and reaction time together explained 45% of the variance in block performance, although neither variable alone was a significant independent predictor. These findings indicate that taekwondo blocking success is supported by a holistic set of factors. To improve defensive performance, training programs should be designed using sport-specific assessment methods, and it is recommended to incorporate light-based reaction drills to enhance reaction speed.
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ArticleAçık Erişim2026/r/ebyu/19018
Nutritional and Inflammatory Indicators for Identifying Sarcopenia in Hemodialysis Patients
Kara, Ali Veysel; Şahin, Hilal; Doğan Akagündüz, Diğdem
Objective: Sarcopenia represents a frequent clinical condition in patients receiving maintenance hemodialysis and is linked to adverse functional and health-related outcomes. Owing to its multifactorial nature, early identification of patients at risk remains challenging in routine practice. This study evaluated nutritional and inflammatory indicators associated with sarcopenia and their ability to identify patients with sarcopenia. Methods: This cross-sectional study included 72 clinically stable adults receiving maintenance hemodialysis between August and September 2024. Sarcopenia was defined according to European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, requiring low muscle strength and reduced muscle mass assessed by handgrip dynamometry and bioelectrical impedance analysis. Nutritional status was evaluated using the Subjective Global Assessment (SGA), and dietary energy and protein intake were assessed using 2 non-consecutive 24-hour recalls analyzed with BEBİS software. Serum albumin, C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio were measured. Multivariable logistic regression and receiver-operating characteristic analyses were performed. Results: Sarcopenia was identified in 18 patients (25%). Sarcopenic individuals had significantly lower protein and energy intake, lower serum albumin levels, and higher CRP concentrations than non-sarcopenic patients. In multivariable analyses, low protein intake (<1.0 g/kg/day), inadequate energy intake (<25 kcal/kg/day), hypoalbuminemia (<3.5 g/dL), elevated CRP (>5 mg/L), and SGA category B/C were independently associated with sarcopenia, whereas adequate energy intake was inversely associated. Receiver-operating characteristic analysis showed acceptable discrimination for individual indicators, with the highest accuracy for serum albumin (area under the curve [AUC] = 0.77). A combined nutritional–inflammatory model integrating dietary intake, albumin, and CRP demonstrated the greatest discriminatory ability (AUC = 0.83). Conclusion: Routinely available nutritional and inflammatory indicators are closely associated with sarcopenia in hemodialysis patients. Their combined assessment may facilitate early identification of individuals with sarcopenia and support timely nutritional evaluation and intervention.
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ArticleAçık Erişim2026/r/ebyu/19014
Ergenlerde Dijital Bağımlılık ve Hedonik Yeme Davranışı Arasındaki İlişki: Tanımlayıcı ve Korelasyonel Bir Çalışma
Aksoy, Bahar; Arslanlı, Sevilay Ergün; Duru, Hilal Altundal; Kasımoğlu, Necla
Giriş: Dijital teknolojilerin yaygın kullanımı, ergenlerde dijital bağımlılık riskini artırmakta ve bu durum çeşitli davra- nışsal sağlık sorunlarıyla ilişkilendirilmektedir. Son yıllarda, dijital medya kullanımının yeme davranışları üzerindeki etkisi giderek artan bir araştırma alanı olmuştur. Bununla birlikte, ergenlerde dijital bağımlılık ile hedonik yeme eğilimi arasındaki ilişkiyi inceleyen çalışmalar sınırlıdır. Amaç: Bu çalışma, ergenlerde dijital bağımlılık ile hedonik yeme eğilimi arasındaki ilişkiyi incelemeyi amaçlamıştır. Yöntem: Bu tanımlayıcı ve korelasyonel çalışma, Aralık 2025 ile Mart 2026 tarihleri arasında, Türkiye'nin doğusunda şehir merkezindeki bir lisede öğrenim gören 346 ergenle gerçekleştirilmiştir. Veriler, Kişisel Bilgi Formu, Ergenler için Dijital Bağımlılık Ölçeği ve Ergenler için Hedonik Yeme Ölçeği kullanılarak toplanmıştır. Tanımlayıcı istatistikler, bağımsız örneklem t-testi, tek yönlü ANOVA, Ki-kare testi, Mann Whitney U testi, Kruskal-Wallis testi ve korelasyon analizleri kullanıldı. Bulgular: Sonuçlar, ekran süresi ile dijital bağımlılık arasında anlamlı pozitif bir korelasyon olduğunu gösterdi (r = 0,328; p < 0,01). Ayrıca, dijital bağımlılık ile hedonik yeme eğilimi arasında da anlamlı pozitif bir korelasyon bulundu (r = 0,351; p < 0,01). Dijital platformların yeme alışkanlıklarını etkilediğini belirten ergenlerin hem dijital bağımlılık hem de hedonik yeme eğilim puanları anlamlı derecede daha yüksekti. Sonuç: Bulgular, ergenlerde dijital bağımlılık ile hedonik yeme eğilimleri arasında önemli bir ilişki olduğunu göster - mektedir. Dijital medya kullanımının ergenlerin yeme davranışları üzerindeki potansiyel etkileri göz önüne alındığında, bu bulgular, sağlıklı ekran kullanımı ve bilinçli yeme davranışlarını içeren okul temelli müdahalelerin geliştirilmesi ihtiyacının altını çizmektedir.
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ArticleYalnız künye2026/r/ebyu/18986
Retrospective analysis of multiplex panel tests in the diagnosis of respiratory tract infections
Ozturk, Ali; Koklu, Ramazan; Aydin, Merve; Celebi, Basar; Altun, Zehra Turkmen; Erdogan, Fatma; Evren, Kubra
Respiratory tract infections (RTIs) remain a major global health concern, particularly in children. The overlapping clinical manifestations of RTIs highlight the need for rapid and accurate diagnostic methods such as multiplex PCR (mPCR). This retrospective single-center study investigated the epidemiology of respiratory pathogens detected by mPCR, focusing on their distribution, age-related patterns, seasonal variation, and coinfections.Nasopharyngeal swab samples from 328 patients with suspected acute RTIs, collected between January 2022 and December 2023, were analyzed using the BioFire FilmArray Respiratory Panel 2.1. Demographic characteristics, clinical findings, pathogen distribution, seasonal trends, and coinfections were evaluated.At least one respiratory pathogen was detected in 270 of 328 specimens, yielding an overall positivity rate of 82.3%. Viral pathogens predominated; human rhinovirus/enterovirus HRV/HEV (28%), adenovirus (21.8%), respiratory syncytial virus (RSV) (14.2%), and influenza viruses (11.3%) were the most frequently identified agents. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human metapneumovirus (HMPV) were detected in 6.8% and 5.8% of cases, respectively. The vast majority of specimens (91.5%) were from pediatric patients (0-18 years). Coinfections were identified in 31.8% of positive cases, most commonly involving adenovirus and HRV/HEV. Seasonal analysis demonstrated a marked increase in positivity during winter and spring months, accounting for 74% of all positive cases. Bacterial pathogens were rarely detected.mPCR demonstrated high diagnostic value, with pathogens detected in 82.3% of samples, predominantly viral agents. These findings support the role of mPCR in improving diagnostic accuracy and providing valuable regional epidemiological data. Rapid identification of viral pathogens may also support antimicrobial stewardship by facilitating more informed clinical decision-making; however, antibiotic utilization was not evaluated in the present study.
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ArticleAçık Erişim2026/r/ebyu/18973
The mediating role of physical self-perception and the moderating effect of gender in the association between physical activity and psychological well-being among young recreational participants
Ekizoglu, Ozlem; Tetik, Sibel; Zambak, Omer; Temur, Canan Sayin; Can, Yusuf; Isik, Utku; Koc, Mustafa Can
Background/objective Psychological well-being disorders are increasingly prevalent among young people. While physical activity is known to benefit psychological well-being, the mechanisms-particularly the role of physical self-perception and gender in recreational context remain underexplored. Grounded in the Conservation of Resources (COR) Theory, this study investigates the mediating role of physical self-perception in the relationship between recreational physical activity and psychological well-being and examines whether gender moderates this mediation among youth aged 15-24.Methods A descriptive-relational survey design was employed. The sample comprised 468 young adults (58.5% male, 41.5% female; M_age = 20.08) who regularly participated in recreational physical activities. Data were collected using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Physical Self-Perception Profile (PSPP), and the Warwick-Edinburgh Mental Well-being Scale (WEMWBS). Mediation and moderation analyses were conducted using PROCESS macro-Models 4 and 7.Results The direct effect of physical activity on psychological well-being was not significant. However, physical self-perception fully mediated the relationship between physical activity and psychological well-being (indirect effect: beta = 0.219, 95% CI [0.151, 0.290]). Among the sub-dimensions of physical self-perception, body attractiveness had the strongest mediating effect. Moderation analysis revealed that gender did not significantly moderate the mediation pathways (a path: p = 0.156; b path: p = 0.954). The mediation mechanism operated with similar strength in both males and females.Conclusion Recreational physical activity improves psychological well-being entirely through the enhancement of physical self-perception, supporting the COR theory that physical activity acts as a resource investment. This mechanism is universal across genders in recreational settings. Interventions aiming to improve youth psychological well-being should not only promote physical activity but specifically focus on fostering positive physical self-perception and body image in inclusive, non-judgmental environments.
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ArticleYalnız künye2026/r/ebyu/18966
Comparative phytochemical profiling, enzyme inhibitory activities, and in silico pharmacokinetic insights of essential oils and extracts from Origanum leptocladum Boiss. and Origanum vulgare subsp. hirtum (link) A.Terracc
Günes, Ferhat; Çeçen, Omer; Özer, Elif Beyza; Yuca, Hafize; Aydin, Bilge; Demirci, Betul; Karakaya, Songul
This study comparatively evaluated the phytochemical and biological profiles of Origanum leptocladum and O. vulgare subsp. hirtum (Lamiaceae). Aqueous extracts yielded more material than methanolic ones, with O. leptocladum showing superior extractability. GC-MS analysis revealed distinct chemotypes: O. leptocladum was rich in cis-sabinene hydrate and p-cymene, whereas O. vulgare was dominated by carvacrol. Methanol extracts of O. leptocladum exhibited the highest alpha-glucosidase inhibition (90.10%) and antioxidant capacity, correlating with elevated phenolic content. Molecular docking indicated strong binding affinities of carvacrol, cis-sabinene hydrate, and p-cymene to alpha-glucosidase, alpha-amylase, AChE, and BChE, implying multitarget inhibitory potential. ADME predictions confirmed favourable pharmacokinetic properties and BBB permeability, especially for carvacrol and cis-sabinene hydrate. This first report on alpha-glucosidase and alpha-amylase inhibition by O. leptocladum underscores its promising antidiabetic and neuroprotective potential, supporting its value for pharmaceutical and nutraceutical development.
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ArticleAçık Erişim2026/r/ebyu/18912
THE RELATIONSHIP BETWEEN SOCIAL EXCLUSION, LOW HEDONISTIC EATING HABITS, AND DELIRIUM İN ELDERLY INDIVIDUALS
Akkas, Ibrahim; Çapar, Elif; Çetintas, Ahmet; Ersoy, Ersan; Kilig, Metin; Çetinkaya, Sahin
Delirium in older adults can be shaped by their experiences of social isolation and a reduction in pleasure-oriented eating habits. When elderly individuals become disconnected from their social environment, this separation can trigger both psychological and biological changes that influence their overall well-being. The aging process entails multidimensional changes in individuals' biological, psychological, and social functioning. The aim of this study is to examine the relationships between levels of delirium and social exclusion and hedonic eating behaviors among individuals aged 65 years and older. In line with its cross-sectional design, the study avoids causal inferences and addresses the relationships between variables within a descriptive and correlational framework. This study aims to explore how strongly social isolation and reduced pleasure-driven eating behaviors relate to the development of delirium in elderly individuals living in institutional care settings. This descriptive research was carried out in In 2025 Erzincan and involved older individuals living in the 100th Year Atat & uuml;rk Nursing Home, the Refahiye Elderly Care Center, and the Kemah Nursing Home. Information was gathered through an elderly demographic form along with the Social Exclusion Scale, the Low Hedonistic Eating Habits Scale, and the Delirium Scale. The dataset was analyzed using descriptive statistics as well as independent samples t-tests, ANOVA, correlation analyses, and regression procedures. In this study, a convenience sampling method was employed.
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ArticleAçık Erişim2026/r/ebyu/18896
Comparison of Intern Doctors and ChatGPT in Emergency Cases Assessment
Kantar, Yusuf; Imamoglu, Melih; Bülbül, Emre; Hayme, Serhat; Eden, Arif Onur; Bilgin, Yasin; Sari, Fatih Mehmet
Objective: Accurate and timely diagnosis in emergency departments is crucial due to the high patient volume and time-sensitive nature of care. Intern doctors, who are nearing the completion of medical school, frequently work in emergency departments in many countries. However, after graduation, physicians are often expected to assume critical patient care responsibilities despite limited experience. Artificial intelligence models can quickly analyze patient data and generate diagnoses, thus assisting inexperienced physicians in enhancing diagnostic accuracy. This study aims to evaluate the diagnostic performance of ChatGPT-4 in emergency department case scenarios and compare its accuracy with that of intern doctors. Materials and Methods: This study involved intern doctors participating in the internship program during the 2024-2025 academic year. A total of 36 case-based questions, categorized by difficulty level, were administered to 155 interns and subsequently presented to artificial intelligence. Descriptive statistics were used to summarize the data, and a one-sample t-test was conducted to compare the diagnostic accuracy between intern doctors and ChatGPT. Statistical significance was set at p<0.05. Results: Intern doctors achieved an overall correct response rate of 58.3%, while ChatGPT achieved a rate of 97.2%. A statistically significant, moderate negative correlation was found between question difficulty and interns' performance (r=-0.684; p<0.001), indicating decreased accuracy as question difficulty increased. ChatGPT consistently demonstrated significantly higher performance across all difficulty levels. Conclusion: ChatGPT-4 may serve as a valuable diagnostic support tool in emergency departments, particularly for newly graduated physicians with limited clinical experience.
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ArticleAçık Erişim2026/r/ebyu/18833
Clinical outcomes and safety of duloxetine and tolterodine combination in the treatment of mixed-type urinary incontinence: A single-arm retrospective study
Polat, Hakan; Eksi, Mithat; Çatik, Alican; Akdag, Azad; Arikan, Yusuf; Sungur, Ubeyd; Kargi, Taner; Karadag, Serdar; Bitkin, Alper
Objective : This study aimed to evaluate the clinical outcomes and safety of combined duloxetine and tolterodine therapy in patients with mixed urinary incontinence. Methods: A retrospective analysis was conducted on patients with mixed urinary incontinence treated between January 2021 and December 2023. Patients received tolterodine (4 mg/day) and duloxetine (40 mg twice daily). Clinical outcomes were assessed at weeks 4 and 12 using the Overactive Bladder Symptom Score, International Consultation on Incontinence Questionnaire-Short Form, pad tests, and bladder diaries. Patient satisfaction was evaluated using the Clinical Global Impression scale. Results: The study included 115 patients (mean age: 46.6 +/- 13.4 years). Significant improvements were observed in Overactive Bladder Symptom Score, International Consultation on Incontinence Questionnaire-Short Form scores, and pad weights at weeks 4 and 12 compared to baseline (p < 0.001). Daily micturition, nocturia, urgency, and incontinence episodes significantly decreased, whereas mean voided volume increased. According to Clinical Global Impression scores, 73.9% of patients reported partial or complete improvement. Treatment-related adverse events were observed in 12.1% of patients. Conclusion: The combination therapy of duloxetine and tolterodine appears to be safe and potentially beneficial, reducing symptom scores and incontinence episodes. However, these findings need to be supported by controlled studies.
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ArticleAçık Erişim2026/r/ebyu/18801
The Effect of Acute Psychotic Period on Physiological Values Measured in Blood in Male Patients With Schizophrenia
Celikel, Guler; Yalcin, Suat; Kalelioglu, Tevfik; Karamustafalioglu, Nesrin
Background: There is increasing evidence that plasma osmolarity is an independent prognostic factor associated with mortality in patients with cardiovascular disease. Whole blood viscosity (WBV) is also associated with established cardiometabolic risk factors for cardiovascular disease. The present study aimed to investigate the effects of the acute phase of schizophrenia on physiological parameters, including WBV and plasma osmolarity, in male patients with schizophrenia.Methods: A total of 121 male patients with schizophrenia were included in this study. Routine blood test results were obtained from hospital records, and the laboratory values required for the calculation of viscosity and osmolarity were recorded. Laboratory data from the patients' most recent acute exacerbation were retrieved from hospital records and used as the acute-phase data.Results: There was no statistically significant difference in serum osmolarity between the acute and remission phases (p = 0.360). Blood urea nitrogen (BUN) and glucose levels were significantly higher during the remission phase, whereas sodium levels were significantly higher during the acute phase. No significant differences were observed in WBV values between the acute and remission phases (p > 0.05). Furthermore, there were no significant differences in WBV-related parameters, including hematocrit (HCT) and total protein, between the two phases. Low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, and triglyceride levels were significantly higher during the remission phase.Conclusions: Although differences were observed in osmolarity-related parameters and viscosity-associated metabolic variables between the acute and remission phases in male patients with schizophrenia, no statistically significant differences were found in serum osmolarity or WBV between the two phases.
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ArticleYalnız künye2026/r/ebyu/18749
From aquatic plant to therapeutic prospect: LC-MS/MS-guided phytochemical profiling and in vitro antidiabetic, anticholinesterase and molecular insights into Myriophyllum spicatum L.
Civas, Ayse; Günes, Ferhat; Özer, Elif Beyza; Imad Abdulqader, Amenah; Akyüz, Beyzanur; Yuca, Hafize; Aydin, Bilge; Karakaya, Songul
Myriophyllum spicatum L. methanolic extract was examined through integrated biochemical, phytochemical, computational analyses. The extract exhibited strong alpha-glucosidase inhibitory activity with an IC50 value of 198.54 & micro;g/mL, demonstrating markedly higher potency than reference inhibitor acarbose (IC50= 4738.12 & micro;g/mL), while no inhibitory activity was detected against alpha-amylase under tested conditions. In anticholinesterase assays, extract showed acetylcholinesterase inhibition with an IC50 value of 9.70 & micro;g/mL, whereas standard inhibitor donepezil exhibited a significantly stronger activity (IC50= 0.30 & micro;g/mL). No inhibitory effect was observed against butyrylcholinesterase for the extract, while donepezil displayed potent inhibition (IC50= 15.40 & micro;g/mL). Extract showed strong ABTS center dot+ scavenging activity (85.7% at 40 & micro;g/mL) but weak DPPH center dot activity (25.6% at 25 & micro;g/mL), suggesting higher affinity for hydrophilic radicals. High total phenolic, flavonoid and tannin contents correlated with antioxidant potential. LC-MS/MS revealed thirteen phenolics, mainly vanillic acid, gallic acid and cyanidin-3-O-glucoside. Docking studies supported selective alpha-glucosidase binding of vanillic acid.
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ArticleAçık Erişim2026/r/ebyu/18730
ATP attenuates olaparib-induced gastric damage in rats
Fakirullahoglu, Mesud; Temiz, Ayetullah; Yeni, Mustafa; Sezgin, Esra Tuba; Yazici, Gulce Naz; Altuner, Durdu; Gulaboglu, Mine; Suleyman, Halis
Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor widely used in cancer therapy, has been associated with gastrointestinal adverse effects; however, the underlying mechanisms remain unclear. Previous studies have suggested that oxidative stress may contribute to olaparib-induced tissue injury.Objective This study aimed to investigate the protective effects of adenosine triphosphate (ATP) against olaparib-induced gastric damage in rats.Methods Animals were divided into healthy control (HG), olaparib alone (OLPG), ATP alone (ATPG), and ATP + olaparib (ATOLG) groups. Gastric injury was evaluated by macroscopic assessment of ulcer area and ulcer number. Histopathological alterations were examined using hematoxylin-eosin (H&E) staining, and oxidative stress status was assessed by measuring lipid peroxidation and antioxidant defense parameters.Results Olaparib administration induced marked gastric mucosal injury, characterized by increased ulcer area and ulcer number, severe histopathological damage, and pronounced oxidative stress. In contrast, ATP co-administration significantly attenuated gastric injury, as evidenced by reduced ulcer area and ulcer number, improved histopathological architecture, and restoration of oxidative balance. Compared with the OLPG group, the ATOLG group showed significant improvement in macroscopic, histopathological, and oxidative stress parameters.Conclusion ATP administration attenuated olaparib-induced gastric damage and improved oxidative stress parameters in rats. Although the underlying mechanisms were not directly investigated in the present study, the obtained findings provide preliminary experimental evidence suggesting that ATP may have protective potential against olaparib-induced gastric injury.
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ArticleYalnız künye2026/r/ebyu/18642
The moderating role of demographic variables on the relationships between job satisfaction, burnout, and turnover intention among nurses
Ulke Simdi, Refika; Gedik, Ozlem; Kara (Sivuk), Derya
PurposeThis study investigated the relationships among job satisfaction, emotional exhaustion, and turnover intention among nurses.Design/methodology/approachThe research was conducted with a sample of 356 nurses employed at a university hospital and examined the moderating roles of demographic variables, including age, marital status, experience at the hospital, and working time in the profession. The data collection tool was organized into two main sections. The first section focused on gathering socio-demographic information, including gender, age, marital status, experience at the hospital, and working time in the profession. The second section comprised validated scales used to measure the study variables. Data analysis was conducted using statistical software. Descriptive statistics were first employed to examine the demographic characteristics of the sample. To test the moderating effects of demographic variables on the relationship between emotional exhaustion and job satisfaction, the PROCESS Macro was utilized. For the moderation analysis, demographic variables such as age, marital status, hospital experience, and professional tenure were utilized. Other variables, including gender and educational status, were used solely for descriptive statistics.FindingsThe findings indicated that experience at the hospital moderated the relationship between job satisfaction and turnover intention, while age, marital status, and working time in the profession moderated the relationship between emotional exhaustion and job satisfaction. Given the critical importance of sustainable human resources in the healthcare sector, these results offer valuable insights for healthcare administrators and policymakers aiming to enhance nurse retention and improve workforce stability.Research limitations/implicationsGiven the critical importance of sustainable human resources in the healthcare sector, these results offer valuable insights for healthcare administrators and policymakers aiming to enhance nurse retention and improve workforce stability. The fact that the study was conducted at a single center in Turkey constitutes a limitation.Practical implicationsThis study offers guidance for healthcare institutions aiming to improve nurse retention. Emotional exhaustion reduces job satisfaction and increases turnover intention, especially among early- and mid-career nurses. Hospitals can reduce turnover through burnout-prevention strategies such as supportive supervision, mentorship, flexible scheduling, and improved staffing and reward systems. The identification of key demographic moderators (e.g. age, experience, marital status) enables institutions to tailor interventions - for example, career-development and coping-skills programs for younger nurses and work-family balance support for mid-career/married nurses.Social implicationsNurse burnout and turnover undermine the quality, safety, and accessibility of patient care. By underscoring the importance of supporting nurses' well-being, this study contributes to public discussions on strengthening healthcare systems. Reducing turnover can enhance patient outcomes, public trust, and system resilience-particularly important during public health crises.Originality/valueIn this study, a contribution to the literature was made by testing the validity of the Conservation of Resources Theory while determining the relationships among job satisfaction, burnout, and turnover intention. Furthermore, the study may provide guidance to healthcare administrators and policymakers in understanding the factors that contribute to workforce retention among nurses.
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ArticleYalnız künye2026/r/ebyu/18581
Impact of Adherence to Mind Diet on Cognitive Function, Frailty, and Physical Activity Levels Elderly Individuals
Sahin, Hilal; Sahin, Habibe
Objective: The study aimed to examine the effect of adherence to the Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet on the cognitive function, frailty, and physical activity levels in elderly individuals. Methods: This cross-sectional study was conducted in primary healthcare centers between November 2020 and October 2021. The Standardized Mini-Mental State Examination (SMMSE), the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale, and the Physical Activity Scale for the Elderly (PASE) were used to examine the cognitive function, frailty, and physical activity levels of participants, respectively. Adherence to the MIND diet score was calculated based on a food consumption record, and a semi-quantitative food consumption frequency questionnaire. Results: The study sample included 150 elderly, with a mean age of 71.31 +/- 5.15 years. The mean MIND diet, SMMSE, FRAIL, and PASE scores were 9.5(7.5-11.0), 22.54 +/- 3.98, 2.00 +/- 1.64, and 191.3 +/- 62.65, respectively. A weak positive correlation (p<.05) was found between the MIND diet score and SMMSE and FRAIL scales; however, no correlation was found with the PASE total score. A one-point increase in the MIND diet score resulted in a 0.002 increase in the mean SMMSE scale score and a 0.450 increase in the mean FRAIL scale score (p<.05). Conclusions: Adherence to the MIND diet was positively correlated with cognitive functions and frailty in elderly individuals. Long-term studies with larger sample sizes should be conducted to further investigate the effects of the MIND diet on cognitive functions and frailty.
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ArticleAçık Erişim2026/r/ebyu/18509
Assessment of Potentially Unnecessary Breast Magnetic Resonance Imaging Utilization and Its Economic Impact: A Retrospective Study
Senbil, Duzgun Can; Kiliçparlar, Muslum Burak; Kantarci, Mecit; Aydin, Sonay
Background: In this study, breast magnetic resonance imaging (MRI) examinations were retrospectively reviewed. This study evaluated whether the indications for breast MRI were consistent with the recommendations of the Breast Imaging Reporting and Data System (BI-RADS)atlas. Additionally, the study assessed whether prior ultrasound and mammography findings were sufficient for diagnosis. The aim was to identify potentially unnecessary breast MRI examinations and their associated financial burden. Methods: Breast MRI reports were compared with previous mammography and ultrasound reports. Patients for whom breast MRI provided no additional diagnostic benefit were identified, and the indications for MRI examination were analyzed. Results: Comparison of BI-RADS categories assigned on prior ultrasound and mammography with those assigned after breast MRI revealed that 321 (64.3%) of the 499 patients could have been adequately managed without breast MRI. In these patients, MRI findings did not alter clinical management or treatment decisions. Conclusion: Breast MRI is a costly imaging modality with limited accessibility in many healthcare settings. Therefore, its economic impact should be carefully considered when determining appropriate indications for its use. These findings suggest that the absence of restrictive criteria for breast MRI requests may contribute to substantial financial losses due to unnecessary examinations.
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