SDG 3 · Sağlık ve Kaliteli Yaşam · SDG · Erzincan Binali Yıldırım Üniversitesi

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MakaleAçık Erişim2025/r/ebyu/12125
Significance of Preoperative Multidisciplinary Assessment with 30-Second Sit-to-Stand and Timed Up-and-Go Tests in Predicting Postoperative Outcomes
Yücel, Mücahid Osman; Sağlam, Sönmez; Dalaslan, Raşit Emin; Arıcan, Mehmet; Karaduman, Zekeriya Okan; Akar, Bedrettin; Çelik, Mücahit; Sav, İsmail
Background/Objectives: Evaluating basic daily activities like sitting, standing, and walking is crucial for predicting preoperative risks and postoperative recovery. These functional abilities can be assessed through patient history or measured using objective tests. For this purpose, the 30-Second Sit-to-Stand (30STS) Test and Timed Up-and-Go (TUG) Test are frequently used in clinical settings. However, few studies have evaluated their effectiveness in anesthesia and orthopedics. In this study, we aimed to assess the applicability of these tests across clinical disciplines. Methods: A total of 43 patients who underwent total knee arthroplasty (TKA) surgery between January and December 2023 with American Society of Anesthesiologists (ASA) scores of 2–3 were retrospectively evaluated. The 30STS, TUG, and VAS scores were recorded preoperatively and on postoperative days 90–180. Results: The preoperative 30STS and TUG scores showed no statistically significant difference between the ASA 2–3 groups, but the ASA 2 group demonstrated a more pronounced performance improvement in both tests during the first 90 days postoperatively. The correlation tests revealed a strong positive relationship with the TUG Test and a moderate positive relationship with the 30STS and VAS scores. Conclusions: The correlation between the preoperative and postoperative results of the 30STS and TUG Tests suggests that preoperative tests can predict post-operative functional performance. However, the lack of a significant statistical relationship between the preoperative tests and ASA scores indicates that these tests may not be sufficiently useful for assessing the functional capacity. The better test outcomes in the ASA 2 patients indicate that combining these assessments with anesthetic evaluations may improve postoperative functional predictions, thereby promoting a multidisciplinary approach.
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MakaleAçık Erişim2025/r/ebyu/12123
Casticin inhibits the hedgehog signaling and leads to apoptosis in AML stem-like KG1a and mature KG1 cells
Erkmen Doǧru, Tuǧba; Gülfidan, Gizem; Ateş, Halil; Arga, Kazlm Yalçln; Koçtürk, Semra
Objectives: Acute myeloid leukemia (AML) is a severe blood cancer with less than 50% long-term survival. Despite advancements in treatment options, relapse is still the major obstacle. The main reason of this problem is ineffective targeting of leukemic stem cells (LSCs), which play an important role in tumor development and relapse. In our previous studies, we found that casticin, the major polyphenolic component of Vitex trifolia's fruit, targets both leukemic cells and LSCs without affecting healthy tissues. Therefore, in this study, we aimed to investigate the effect of casticin-mediated cell death in relation to the LSCs-favored survival pathways at gene and protein expression levels using in vitro LSC-like and parental leukemic cell models. Methods: We validated the LSC character of KG1a and KG1 cells (84.55% CD34+, CD38- and 93.55% CD34+, CD38+, respectively) by flow cytometry. For the investigation of casticin's mechanism of action, we employed real time-PCR, western blotting and bioinformatics analyses. Results: Our results showed an increase in cleaved PARP/β-actin ratio but no change in LC3BI/II and SQSTM/β-actin ratios. Our gene expression, bioinformatics and immunoblotting analyses represented significant decrease in Shh, Gli and Wnt levels. We also elucidated a possible crosstalk between Hedgehog and other oncogenic cascades via the Gli, Notch, YAP, p38, Mcl-1, and Myc proteins in casticin mediated anti-leukemic effect. Conclusions: In conclusion, we found that casticin induces apoptosis in both LSC-like and parental leukemia cells mainly by suppressing Shh signaling, which is crucial for LSC survival and AML relapse.
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MakaleAçık Erişim2025/r/ebyu/12121
Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry
Beyaz, Şengül; Erdinç, Münevver; Hayme, Serhat; Aslan, Ayşe Feyza; Aydın, Ömür; Gökmen, Derya; Buhari, Gözde Köycü; Sözener, Zeynep Çelebi; Gemicioğlu, Bilun; Bulut, İsmet
Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.76% (n = 1268; mean age: 46.2 ± 14.3 years), predominantly females (~76%), received montelukast. Montelukast users showed higher rates of allergic rhinitis (P < 0.001), hyper-sensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) (P = 0.008), and chronic rhinosi-nusitis (P = 0.008). Montelukast group also had higher atopy and total IgE levels and tended to be more eosinophilic. Montelukast was commonly preferred in allergic, eosinophilic, NSAID-exacerbated respiratory disease, and severe asthma phenotypes (P < 0.001). Patients receiving Steps 4 and 5 treatments are more likely to be prescribed montelukast (P < 0.001). Montelukast usage was higher among patients with uncontrolled asthma [ACT< 20 (OR:1.29, 95%CI:1.052–1.582, P = 0.014)]. In addition, logistic regression analyses identified the main factors associated with increased montelukast use as; female gender (OR:1.33, 95%CI:1.041–1.713, P = 0.02), presence of atopy (OR:1.46, 95%CI:1.157–1.864, P = 0.002), comorbid allergic rhinitis (OR:2.12, 95%CI:1.679–2.293, P < 0.001), and severe asthma (OR:2.18, 95%CI:1.712–2.784, P < 0.001). These findings reveal that montelukast use is prevalent among asthma patients, particularly in females, middle-aged adults, and those with comorbid allergic rhinitis, uncontrolled asthma, or specific asthma phenotypes, underscoring the factors that influence its prescription in asthma management.
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MakaleAçık Erişim2025/r/ebyu/12097
COVID-19 Incidence and Factors Influencing Infection Risk Among People Living With HIV in Türkiye: Is Current Issue the Vaccine Hesitancy-Opposition?
Inan, Asuman; Barkay, Orcun; Karapınar, Arda; Yılmaz-Karadag, Fatma; Aktas, Selman; Bolukcu, Sibel
Introduction: As the Coronavirus Disease-2019 (COVID-19) pandemic intersects with the ongoing Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) crisis, concerns have emerged regarding the susceptibility of people living with HIV/AIDS (PLWH) to severe outcomes from COVID-19. Despite global efforts to understand the interplay between HIV/AIDS and COVID-19, research on this issue remains limited in Türkiye. This study investigates the incidence of COVID-19 among PLWH in Türkiye and factors influencing infection risk. Materials and Methods: An online survey, conducted from April to June 2023, assessed COVID-19 frequency and risk factors among PLWH aged 18 years and older in Türkiye. Demographic data such as age, gender, educational background, underlying health conditions, vaccination status, and COVID-19 infection history were collected from individuals who voluntarily participated. Results: A total of 354 PLWH from 38 cities in Türkiye participated in the study. The median age was 35.8 (range 18–76); 78% were male and 65.5% were university graduates. The rate of experienced COVID-19 among PLWH was 44.6%. Logistic regression analysis revealed that vaccinated individuals had an 84% lower risk of contracting COVID-19 among PLWH. In sum, 80 participants were not vaccinated in this study; of them, 27.5% identified as vaccine opponents and 25% expressed vaccine hesitancy. Discussion: These findings suggest that vaccination status is the key determinant of COVID-19 susceptibility among young and well-educated PLWH in Türkiye. The notable level of vaccine hesitancy and opposition of PLWH highlights the need for public health initiatives aimed at addressing misinformation and enhancing vaccine confidence. Conclusion: This study underscores the urgent need to address vaccine hesitancy and vaccine opposition among educated PLWH in Türkiye. Amid evolving SARS-CoV-2 variants, vaccination remains paramount in mitigating COVID-19 risks among PLWH. Further research should delve deeper into demographic-specific vaccine concerns to optimize public health strategies and meet the unique needs of PLWH communities.
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DüzeltmeAçık Erişim2025/r/ebyu/12093
Corrigendum to “Effect of ferritin, INR, and D-dimer immunological parameters levels as predictors of COVID-19 mortality: A strong prediction with the decision trees” [Heliyon Volume 9, Issue 3, March 2023, Article e14015] (Heliyon (2023) 9(3), (S2405844023012227), (10.1016/j.heliyon.2023.e14015))
Huyut, Mehmet Tahir; Huyut, Zübeyir
In the original published version of this article, the ethics committee approval number was missing in the Ethical approval section: Institutional Review Board Statement: The dataset used in this study was collected to be used in various studies in the estimation of the diagnosis, prognosis, and mortality of COVID-19. The necessary permissions for the collected dataset were given by the Ministry of Health of the Republic of Turkey and the Ethics Committee of Erzincan Binali Yıldırım University. This study was conducted following the 1989 Declaration of Helsinki. Erzincan Binali Yıldırım University Human Research Health and Sports Sciences Ethics Committee. This has now been added and the Ethics approval section revised to be more concise. The correct version can be found below: Institutional Review Board Statement: The dataset used in this study was collected to be used in various studies in the estimation of the diagnosis, prognosis, and mortality of COVID-19. The necessary permissions for the collected data set were obtained from the Ministry of Health of the Republic of Turkey. This study was approved by Erzincan Binali Yıldırım University Clinical Research Ethics Committee (31.03.2022, Report No: 03–09). The authors apologize for the errors. Both the HTML and PDF versions of the article have been updated to correct the errors.
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MakaleAçık Erişim2025/r/ebyu/12088
Perceived social support and school engagement in sports science students: The moderated mediation of school alienation and social media addiction
Esentürk, Oğuz Kaan; Seçer, Emrah; Yarimkaya, Erkan; İlhan, Ekrem Levent
Introduction and Purpose: This study investigated how sports science university students perceive social support (PSS), its influence on their academic engagement, and the mechanisms that mediate this relationship. Methodology: A total of 466 students (316 males, 150 females) from the Faculty of Sports Sciences participated in the study, which used a relational screening model. Data were collected using the Multidimensional Perceived Social Support Scale, the University Students School Engagement Scale, the School Alienation Scale, and the Social Media Addiction Scale. The measurement model was validated through confirmatory factor analysis, followed by correlation testing and regression analysis using the Bootstrap method to evaluate the study's hypotheses. Results: The analysis identified a positive correlation between PSS and school engagement (SE) (r = 0.45, p < 0.001). In contrast, PSS showed negative correlations with both school alienation (SA) (r =-0.209, p < 0.01) and social media addiction (SMA) (r = −0.113, p < 0.01) (Hypothesis I). Regression analysis using the Bootstrap method revealed a significant indirect effect of PSS on SE via SA (Hypothesis II) [β = 0.181, p < 0.001, 95% Confıdence Interval (CI) = (0.003, 0.039)]. Additionally, SMA moderated the indirect effect of PSS on SE via SA (Hypothesis III) [Situational mediator index = −0.018, Boot SE = 0.001, Boot 95% CI = (−0.003, −0.0001)]. The indirect effect was stronger for individuals with low SMA [Indirect effect = 0.034, Boot SE = 0.182, Boot 95% CI = (0.007, 0.078)] compared to those with high SMA [Indirect effect = 0.018, Boot SE = 0.009, Boot 95% CI = (0.005, 0.0416)]. Conclusion: The findings support all three hypotheses in the study's theoretical framework, confirming the proposed relationships and underlying mechanisms.
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MakaleAçık Erişim2025/r/ebyu/12086
Herbal Product Use and Drug-Herbal Product Interactions in Patients with Chronic Diseases-A Cross-Sectional Study; [Kronik Hastalığı Olan Hastalarda Bitkisel Ürün Kullanımı ve İlaç-Bitkisel Ürün Etkileşimleri-Kesitsel Bir Anket Çalışması]
Polat, Eyup Can; Gozcu, Sefa
Herbal products are frequently used to prevent and treat diseases in the community. Although they are considered safe because they are natural, the simultaneous use of herbal products with drugs may cause drug-related problems and negatively affect therapeutic outcomes. Our study aimed to determine the herbal product use rates of patients with chronic diseases and the interactions of the herbal products used with drugs. This study is a cross-sectional survey conducted in a community pharmacy. The study included adult patients with chronic diseases who used regular drugs and had a history of using herbal products within the previous three months. The surveys included questions about patients’ demographics, diseases, drugs, and herbal products. Drug-herbal product interactions were examined through databases, monographs, and books. 93 of 148 patients were using herbal products. Most of the patients were diagnosed with hypertension and diabetes. The use of herbal products was found to be positively correlated with undergraduate educational status, asthma, COPD, diabetes, and anxiety (p<0.05). The herbal product that was most used and had the most drug interactions was garlic. The majority of drug-herbal product interactions were determined by the “drugs.com” interaction checking tool and the WHO monographs. Pharmacists should provide consultancy services to their patients on the use of herbal products. It is advisable for community pharmacists to keep their knowledge on drug-herbal product interactions updated. They can benefit from training programs on drug-herbal product interactions organized by clinical pharmacists. Thus, drug-herbal product interactions that may occur in patients can be reduced.
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MakaleAçık Erişim2025/r/ebyu/12070
Pyrrole-Tethered Bisbenzoxazole Derivatives: Apoptosis-Inducing Agents Targeting Breast Cancer Cells
Kuzu, Burak; Yetkin, Derya; Hepokur, Ceylan; Algul, Oztekin
This study presents the design, synthesis, and biological evaluation of a series of novel pyrrole-tethered bisbenzoxazole (PTB) derivatives as potential apoptosis-inducing agents targeting the MCF-7 human breast cancer cell line. The anticancer activity of these compounds was evaluated in vitro using the MTT assay, with tamoxifen serving as the reference therapeutic agent. Compounds B8, B14, and B18 demonstrated remarkable cytotoxicity against MCF-7 cells, exhibiting approximately 8-fold lower IC50 values compared to tamoxifen, while showing minimal effects on healthy fibroblasts. Further investigations revealed that these compounds effectively induced early-stage apoptosis and selectively arrested the cell cycle at the G1 phase in cancer cells. Gene expression analysis confirmed selective activation of the caspase-9-mediated apoptotic pathway in MCF-7 cells, providing insights into their underlying molecular mechanisms. These findings highlight the promising potential of PTB derivatives as potent anticancer agents, laying the groundwork for the development of targeted therapies for breast cancer that leverage apoptosis induction for improved therapeutic outcomes.
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MakaleYalnız künye2025/r/ebyu/12065
Development of lacosamide-loaded in-situ gels through experimental design for evaluation of ocular irritation in vitro and in vivo
Çoban, Özlem; Pınar, Sıla Gülbağ; Polat, Heybet Kerem; Gedik, Gülşah; Karakuyu, Nasıf Fatih; Pezik, Esra; Ünal, Sedat; Mokhtare, Behzad; Akşit, Aleyna
Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl D-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli. They can show mucoadhesive properties related to the polymer used and increase the residence time of the drug in the mucosa. In the presented study, ocular in-situ gel formulation of LCM, which has potential for use in ocular diseases and consists of hyaluronic acid and poloxamer 407 as polymers, was developed using cold method. The effect of formulation components on target product properties (pH, gelation temperature and viscosity) was evaluated by design of experiments (DoE) design. The optimized LCM-loaded in-situ gel had a pH value of 6.90 ± 0.01, showed pseudo-plastic flow with a viscosity of 562 ± 58 cP at 25 °C, gelled at 33 ± 0.47 °C, and released drugs via the Peppas-Sahlin mechanism. Ocular safety was confirmed via in vitro tests using two different cell lines (L929 and Arpe-19), along with in vivo Draize tests, histological examinations, and Hen's Egg Chario-Allontioc-Membrane (HET-CAM) analysis. In vitro studies confirmed the optimized LCM-loaded in-situ gel's suitability for ocular use, demonstrating long-acting effects through controlled release. In addition, ocular irritation and histological studies have supported that it will not show any toxic effect on the eye tissue.
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MakaleYalnız künye2025/r/ebyu/12062
How Do Life Positions Mediate the Relationship Between Cognitive Flexibility and Teacher Subjective Well-Being?
Arı, Ahmet Emın; Korkmaz, Burak Can; Özpolat, Ahmet Ragıp; Eşkısu, Mustafa
Within the school context, subjective well-being in teachers is a crucial determinant of their efficacy. Growing research has shown that teacher subjective well-being is linked to cognitive flexibility. The aim of the current study was to examine the mediating effect of life positions (i.e., healthy and unhealthy life positions) on the association between cognitive flexibility and teacher subjective well-being. The study included 302 teachers from public schools in Turkey. Participants were 56% female and 44% male, ranging in age from 23 to 64 years old. The findings indicated that cognitive flexibility was significantly and positively related to a healthy life position and teacher subjective well-being but negatively to an unhealthy life position. The results also suggested that a healthy life position significantly mediates the relationship between cognitive flexibility and teacher subjective well-being. Thus, a healthy life position is a crucial mechanism that may explain the impact of cognitive flexibility on teacher subjective well-being.
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DüzeltmeYalnız künye2025/r/ebyu/12060
Corrigendum to: The Effect of Some Symptoms and Features During the Infection Period on the Level of Anxiety and Depression of Adults after Recovery from COVID-19 (Current Psychiatry Research and Reviews, 18, 2, (151-163), 10.2174/2666082218666220325105504)
Huyut, Mehmet Tahir; Kocatürk, İdris
The authors would like to acknowledge the oversight in omitting the ethical approval number in the article titled “The Effect of Some Symptoms and Features During the Infection Period on the Level of Anxiety and Depression of Adults after Recovery from COVID-19” published in Current Psychiatry Research and Reviews, 2022, 18(2), pp: 161 [1]. Details of the error and a correction are provided here. ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocol was approved by the Institutional Ethics Review Board of Erzincan Binali Yıldırım University after being approved by the Ministry of Health of the Republic of Turkey. HUMAN AND ANIMAL RIGHTS: No animals were used in this study. The procedure of the human experiments is in accordance with the Declaration of the Helsinki World Medical Association. ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was approved by the Erzincan Binali Yıldırım University Human Research Health and Sports Sciences Ethics Committee (20/10/2021, Protocol No: 08-03) and the Ministry of Health of the Republic of Turkey. HUMAN AND ANIMAL RIGHTS: The reported experiments on humans were in accordance with the ethical standards of the committee responsible for human experimentation (institutional national), and with the Helsinki Declaration of 1989. We regret the error and apologize to readers. The original article can be found online at https://www.eurekaselect.com/article/121872
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MakaleAçık Erişim2025/r/ebyu/12059
Cone beam computed tomography assessment of the anatomical variations in mandibular lingual foramen: A strobe retrospective cross-sectional study
Ocak, Ali
The anterior mandible is a region that may frequently receive insufficient attention in surgical interventions; however, is crucial to recognize that this area associated with significant complications due to the presence of lingual foramina and the vascular structures passing through it. Notably, these foramina may exhibit variations in both different numbers and locations, necessitating diligent during surgical planning. The objective of this study is to evaluate the location, distribution, and prevalence of the median lingual foramen and lateral lingual foramen (LLF) as identified through cone-beam computed tomography (CBCT) in a sample drawn from the Turkish population. Measurements were taken concerning the frequency, distribution, location, and diameter (Df) of both the median lingual foramen and LLF. Additionally, the vertical distance to the inferior border of the mandible (Hinf) for each foramen, the horizontal distance (Hhor) from the deepest point of the median lingual canal and lateral lingual canal to the buccal cortical plate, as well as the lengths of the canals (Lc) were systematically recorded. The analysis revealed no statistically significant differences in the prevalence of lingual foramina or in the measurements of Df, Hinf, Hhor, and Lc when comparing male and female patients. It was observed that all CBCT scans exhibited the presence of at least 1 lingual foramen in the mandible. Notably, a significantly greater occurrence of LLFs was identified in the mandibular premolar region compared to other anatomical regions. The findings indicate a higher prevalence of mandibular lingual foramina within the Turkish population compared to previous studies. Specifically, the variations in the anatomy of mandibular lingual foramina and canals warrant careful consideration through CBCT imaging prior to surgical interventions in proximity to the inner surface and basis of the mandible, particularly in the anterior and premolar regions, to mitigate the risk of potential complications.
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MakaleAçık Erişim2025/r/ebyu/12051
Digital Alignment Accuracy of Zirconia Abutments Using Library Data on Incompletely Captured Implant Impressions: An In Vitro Study; [Eksik Dijital İmplant Ölçülerinde Zirkonya Abutmentlerin Kütüphane Verisi ile Dijital Eşleştirme Doğruluğu: İn Vitro Çalışma]
Topdağı, Başak; Oktay, Fatih; Akar, Türker
Objectives: This in vitro study aimed to evaluate the feasibility and accuracy of digitally aligning zirconia customized abutment library files onto incomplete abutment scan datasets. Superimposition was compared to the conventional “Close holes” reconstruction function in computer-aided design (CAD) software. Materials and Methods: A single-implant dental model was used, and a custom zirconia abutment was scanned to generate a digital library file. Complete scans of the abutment and adjacent teeth served as the control group (C). Two experimental datasets were produced by selectively deleting marginal regions (NC2) and both marginal and proximal surfaces (NC3) from the complete scan. Defective scans were processed either by digital superimposition with the abutment library file (S group) or by applying the “Close holes” function in CAD software to reconstruct missing areas (CH group). All datasets were analyzed in Geomagic Control X (3D Systems, USA) to assess trueness using root mean square (RMS) error and point-based deviation analysis. Statistical evaluation was performed using one-way ANOVA and Tukey HSD post hoc tests Results: Superimposition significantly improved trueness compared with unprocessed scans. RMS values decreased from 39.11 ± 0.98 μm in the IOS (intraoral scanner) group to 35.41–37.59 μm across the C, NC2, NC3, and S groups datasets (p = 0.032). The CH group showed significantly higher deviations than all superimposition groups (p < 0.001). Point-based analysis confirmed lower deviations after superimposition (p = 0.008). No significant differences were found among the superimposed groups. Conclusions: Digital superimposition of zirconia abutment library data onto incomplete scans enhances trueness and geometric reliability. This method is superior to conventional reconstruction tools for restoring incomplete implant impressions.
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MakaleAçık Erişim2025/r/ebyu/12048
Pregabalin as a neuroprotective alternative to methylprednisolone in peripheral nerve regeneration: an experimental study
Ateş, İrem; Laloglu, Esra; Küçün, Neslihan; Ozmen, Sevilay; Yıldırım, Serkan; Pür, Basri; Köse, Duygu; Civelek, Maide Sena; Kahramanlar, Agah; Işık, Bahar
Background Peripheral nerve injuries are particularly important in terms of their frequency and complications. The purpose of this experimental study was to investigate the neuroprotective effects of pregabalin and methylprednisolone administered at different doses and in combination in an axonotmesis model and to establish whether pregabalin can represent an alternative to methylprednisolone. Methods Fifty-six adult male Sprague-Dawley rats were assigned to control, sham (axonotmesis only), axonotmesis + pregabalin 30 mg/kg (low dose), axonotmesis + pregabalin 60 mg/kg (high dose), axsonotmezis + 1 mg/kg methylprednisolone, axonotmesis + pregabalin 30 mg/kg + 1 mg/kg methylprednisolone (low-dose combination), and axonotmesis + pregabalin 60 mg/kg + 1 mg/kg methylprednisolone (high-dose combination) groups. Following axonotmesis, the treatment groups received oral treatment once daily for one week. Sciatic functional index, electromyography, biochemical (NGF, TGF-β, CNTF, MBP), immunohistochemical, histomorphological and immunofluorescence analyses were performed to assess the neuroprotective effects of the treatments. Results Immunohistochemical, electrophysiological, and biochemical analyses demonstrated that the separate or combined use of pregabalin and methylprednisolone may have positive effects on nerve regeneration. Conclusion Low-dose pregabalin and methylprednisolone alone exhibited similar effects on peripheral nerve regeneration and functional healing. Pregabalin may represent an alternative to steroids due to its fewer side effects. Although direct pain behavior assessment was not performed in this study, the effect of pregabalin on neuropathic pain may be additionally beneficial in combined use. These results demonstrate that pregabalin offers comparable neuroregenerative effects to methylprednisolone, with combination therapy proving superior. This positions pregabalin as a promising steroid-sparing agent for peripheral nerve injury, warranting further clinical investigation.
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MakaleAçık Erişim2025/r/ebyu/12041
Investigation of individual cultural values and perceived gender role on disaster management in Generation Z earthquake victims
Akkaş, Ibrahim; Bulbuloglu, Semra; Aslan, Sinan; Cetintas, Ahmet
Introduction: High magnitude earthquakes are a natural disaster, often resulting in psychosocial and economic devastation. In patriarchal societies, women may suffer more losses than men and may be disadvantaged in earthquake management. Generation Z has more independent personal characteristics than previous generations, which may have an impact on gender perceptions and individual cultural values on earthquake management. Objective: This study aimed to examine the gender perception and individual cultural values of Generation Z earthquake victims on earthquake management. Method: This descriptive study was conducted in Malatya, one of the cities affected by the earthquake on February 6, 2023, 2 years after the earthquake, with the participation of n = 226 Generation Z earthquake victims who married or sharing a home with a partner for at least 6 months. Earthquake victim information form, Perception of Gender Role on Disaster Management Scale (PGR-DMS) and Individual Culture Values Scale (CVSCALE) were used for data collection. The PGR-DMS measures gender perception, and higher scores indicate a more positive gender perception. CVSCALE measures individual cultural values and has five sub-dimensions: Power Distance, Uncertainty Avoidance, Collectivism, Long-Term Orientation and Masculinity. Higher score on a subscale indicates that participants embrace the cultural value measured in that dimension for CVSCALE. Descriptive tests, Mann–Whitney U, Chi Squared and Spearman Rho correlation tests were used in data analysis. Results: 75.7% of the Generation Z earthquake victims who participated in the study were between 21 and 25 years old and 72.6% were female. 63.3% of Generation Z earthquake victims were high school graduates and 74.3% were employed. 20.8% of Generation Z earthquake victims had a chronic disease, and 15.5% of them had a spouse with a chronic disease. As a result of this study, the PGR-DMS was higher in earthquake victims whose spouses had chronic diseases and this difference was statistically significant (p = 0.030). There was a statistically significant strong relationship between the number of children and PGR-DMS (r = 0.711, p = 0.014). There was a positive, strong and statistically significant correlation between PGR-DMS and Collectivism (r = 0.754, p = 0.021). Conclusion: As a result of this study, having a chronic disease in the spouse of Generation Z earthquake victims and an increase in the number of children positively increased the perception of gender in earthquake management. Generation Z earthquake victims’ perception of gender in earthquake management, Collectivism and Long-term orientation were above average. As the collectivism of Generation Z earthquake victims increased, the perception of gender in earthquake management raised positively.
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Kitap BölümüYalnız künye2025/r/ebyu/12040
Lung Cancer
Akbay, Makbule Özlem; Unver, Edhem
Lung cancer ranks high among the many cancers that claim to live in the USA. More women have died from lung cancer than breast cancer since 1987. Approximately 160,000 Americans lose their lives to lung cancer each year, and the disease is predicted to produce 225,000 new cases each year. Curiously, at the turn of the twentieth century, lung cancer was a rare occurrence. The growth in smoking among both sexes is mainly responsible for its meteoric ascent in the subsequent decades. The two most common types of lung cancer are small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). About 85% of lung cancers are non-small-cell lung tumors. More specific subtypes of non-small cell lung cancer (NSCLC) exist according to histology, including adenocarcinoma, SCC, and large cell carcinoma.
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MakaleAçık Erişim2025/r/ebyu/12039
Comparative Analysis of Nutritional, Physicochemical, Microbiological, and Sensorial Characteristics of Dairy Yogurts Containing Probiotic Bacteria and Sandalwood Essential Oil Versus Plant-Based Yogurts Made From Lupine Milk
Çebi, Kadir; Yangılar, Filiz
Nowadays, individuals with cow's milk allergy have shown greater interest in plant-based (PB) milk alternatives. This study addresses this issue by producing cow's milk yogurt, lupin-based yogurt, and a hybrid of cow's and PB milk yogurt. In addition, a safe food formulation was developed by incorporating probiotic bacteria and sandalwood oil into these yogurt types. Statistical analysis revealed that the type of milk significantly influenced the physicochemical properties of the yogurts (p < 0.05). The highest mean syneresis (6.78 mL/25 g) was observed in the cow's milk yogurt (C2), whereas the combination of dairy and lupin-based yogurt (CL2) exhibited the greatest water-holding capacity (WHC) (3933 cP). The total phenolic content (TPC) across all yogurt samples ranged from 6.67 to 19.58 mg GAE/g, with the lupin-based yogurts showing the highest values. Specifically, the lupin-based yogurt (L4) displayed the highest antioxidant activity of 34.14%, compared to 9.49% in dairy yogurt (C1). Throughout the storage period, Lactobacillus acidophilus counts remained above 8.45 log cfu/mL in dairy yogurt and 7.78 log cfu/g in lupin-based yogurt. The firmness, cohesiveness, and viscosity index values of lupin-based yogurts were higher than those of the other yogurt types. Organoleptic analysis indicated that PB yogurts were similarly well-received as dairy products.
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Derleme MakaleAçık Erişim2025/r/ebyu/12037
An overview of ELISA: a review and update on best laboratory practices for quantifying peptides and proteins in biological fluids
Aydin, Suleyman; Emre, Elif; Ugur, Kader; Aydin, Mustafa Ata; Sahin, İbrahim; Cinar, Vedat; Akbulut, Taner
The enzyme-linked immunosorbent assay (ELISA) detects antigen-antibody interactions by using enzyme-labelled conjugates and enzyme substrates that generate colour changes. This review aims to provide an overview of ELISA, its various types, and its applications in detecting metabolites in biological fluids. The article discusses the history of the assay, its underlying principles and procedures, common ELISA protocols, and the most accurate and reliable techniques for measuring peptide molecules in biological fluids. Additionally, we emphasize best laboratory practices to achieve consistent, high-quality results and outline the essential materials for setting up an ELISA laboratory, drawing from our over 30 years of experience in the field.
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MakaleAçık Erişim2025/r/ebyu/12034
Exploring Shootin1’s oncogenic role within FGFR2 gene fusions
Ergin, Volkan; Erdoğan, Mutlu; Yaşar, Ekrem; Zheng, Sika
Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with Chemistry at HARvard Macromolecular Mechanics–Graphical User Interface (CHARMM–GUI). Results: We found that FGFR2::SHTN1 is an in-frame fusion formed by the joining of upstream FGFR2 exons 1–17 with downstream SHTN1 exons 7–17 in human, resulting in a chimeric protein retaining the intact FGFR2 tyrosine kinase domain. Our analyses revealed that Shootin1 inherently forms oligomers through its coiled–coil domains, which, within the fusion, mediate ligand-independent dimerization and constitutive activation of FGFR2. Conclusion: Our findings establish FGFR2::SHTN1 as a potent oncogenic driver in various cancers, particularly in cholangiocarcinoma, highlighting a unique mechanism of constitutive activation mediated by Shootin1’s CCD-II domain. This study represents the first molecular characterization of the FGFR2::SHTN1 fusion, advances understanding of FGFR2 fusion biology, and identifies a particular target for future diagnostic and therapeutic strategies in relevant malignancies.
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MakaleAçık Erişim2025/r/ebyu/12027
Magnetic resonance arthrography with positional manoeuvre for the diagnosis of synovial fold of posterior shoulder joint capsule
Keles, Papatya; Ogul, Hayri; Tuncer, Kutsi; Sakci, Zakir; Ay, Mutlu; Kantarci, Mecit
Objectives: The objective of this study is to prospectively assess the effectiveness of shoulder magnetic resonance (MR) arthrograms with positional manoeuvres in detecting posterior synovial folds. Methods: Two radiologists independently assessed all axial MR arthrograms in internal rotation, neutral position, and external rotation for the presence of a posterior synovial fold. The diagnostic performances of the MR arthrograms were then compared, with results validated through arthroscopy. Results: Arthroscopy was performed on 81 of the 150 patients included in the study. A posterior synovial fold was identified arthroscopically in eleven of these patients. Measurements of the posterior synovial fold obtained in external rotation and the neutral position of the arm showed a significant correlation with arthroscopic results (p < 0.05). For detecting the posterior synovial fold with arthroscopic correlation, the sensitivity and specificity values for observer 1 and observer 2 were 100–81.4% and 100–88.6%, respectively, for MR arthrograms in the neutral position; 100–52.9% and 100–62.9% for MR arthrograms in external rotation; and 100–95.7% and 81.8–98.6% for MR arthrograms in internal rotation. There was a fair agreement for MR arthrography in external rotation for detecting posterior synovial folds, while MR arthrograms in internal rotation and neutral position showed near-perfect and significant interobserver agreement. Conclusion: The rotational positions of the humeral neck during MR arthrographic examination can influence the diagnostic specificity and sensitivity of axial MR arthrograms in detecting the posterior synovial fold. Clinical relevance statement: The posterior synovial fold can mimic a posterior labral detachment. Therefore, its correct identification is crucial in order to avoid unnecessary surgical procedures. Key Points: Movement of the shoulder may introduce variability in MR arthrography appearance. Rotation of the humeral neck during MR arthrography can affect diagnoses in posterior synovial fold detection. Given that posterior synovial folds can imitate posterior labral detachment, their correct identification is crucial to avoid unnecessary surgical procedures.
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