Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleAçık Erişim2024
    İntihar Ruminasyon Ölçeği’nin Türkçeye Uyarlanması: Geçerlilik ve Güvenirlilik Çalışması

    Erdem, Metin; Negiz, Zeynep Uyanık; Akinci, Habibullah

    Amaç: Kişinin özgür iradesi ile kendi yaşamını sonlandırması intihar olarak tanımlanabilir. İntihar kararının verilmesinde farklı ge rekçeler olabilmektedir. İntihar düşüncesi insan ve toplum sağlığı için risk teşkil eden bir özelliktedir. Bu düşüncenin ortaya çıkması, şiddet lenmesi ve süreğen hâle gelmesi insanın iyilik hâlini de tehdit etmekte dir. Bu sebeple kişinin intihar düşüncesi üzerine disiplinler arası çalışmalar önem arz etmektedir. Bu çalışmacının amacı, İntihar Rumi nasyon Ölçeği’ni Türk kültürüne uyarlamaktır. Bu kapsamda Türkçe for munun geçerlilik ve güvenirliği test edilmiştir. Gereç ve Yöntemler: Araştırmaya intihar düşüncesinin olduğu 167 (41 erkek ve 126 kadın) kişi katılmıştır. Ölçek Türkçe diline çevrildikten sonra İngilizce alanında bir dil uzmanı tarafından Türkçe çeviri kontrol edilmiştir. Dil geçerliği nin uygun olduğuna karar verilmiştir. Yapı geçerliğini test etmek için öncelikle açımlayıcı faktör analizi (AFA) uygulanmış ve maddelerin iki faktörde dağılımı gözlenmiştir. Sonra doğrulayıcı faktör analizi (DFA) uygulanmıştır. AFA için Jamovi uygulaması, DFA için LISREL uygu laması kullanılmıştır. Taslak ölçme aracının güvenirliğini test etmek için Cronbach alfa iç tutarlık katsayısı hesaplanmıştır. Bulgular: Analizler sonucunda kabul edilebilir uyum indeksleri ile karşılaşılmıştır (χ²/sd=1,754, karşılaştırmalı uyum indeksi=0,99, normlaştırılmamış uyum indeksi=0,99, kök ortalama kare yaklaşım hatası=0,067). İntihar Ruminasyon Ölçeği’nin iç tutarlılık katsayısının 0,89 olduğu saptan mıştır. Sonuç: Sonuç olarak, belirtilen örneklemde İntihar Ruminasyon Ölçeği’nin geçerli ve güvenilir sonuçlar sunacağı söylenebilir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    The Effect of Professional Volleyball Players’ Mental Endurance, Imagination, and Internal Speech Levels on the Way They Cope with Stress

    Ekizoğlu, Özlem; Acet, Mehmet; Toros, Can

    The aim of this research is to reveal whether professional volleyball players’ mental endurance in sports, visualization in sports, talking to themselves, and strategies for coping with stress in sports differ according to their gender, age, and marital status. In addition, the aim was also to examine the effects of mental endurance in sports, imagery in sports. and self-talk on the strategy of coping with stress in sports. A total of 56 professional volleyball athletes, 33 women and 23 men living in Kütahya, participated in the study. Data were collected with a personal information form and a total of four scales: mental endurance in sports, visualization in sports, self-talk, and strategies for coping with stress in sports inventory. Findings were obtained by independent sample t-test, one-way ANOVA, correlation, and multiple regression analysis using the Statistical Package for Social Sciences version 21.0 software (IBM Corp.; Armonk, NY, USA). As a result, the gender, age, and marital status of the participants did not make a significant difference on their mental endurance and imagination; It was found that those who were single had higher self-talk and stress coping strategy scores than those who were married. In addition, as the participants’ ages increase, their stress coping strategy scores decrease and their stress coping strategies in sports. It has been found that it affects mental endurance in sports by 15%, imagination in sports by 38%, and self-talk by 43%.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2024
    Sağlık Çalışanlarının Zorunlu Vatandaşlık Davranışının Hizmet Süreçlerini Sabote Etme Davranışı Üzerine Etkisi: Sosyal Kaytarma ve Yüzeysel Rol Yapmanın Paralel Aracılık Rolü

    Baş, Murat; Ersari, Goknur; Tarsuslu, Sinan; Ekinci, Lokman Onur

    Bu çalışma sağlık çalışanlarının, zorunlu vatandaşlık davranışları ile hizmet süreçlerini sabote etme eğilimleri arasındaki ilişkide sosyal kaytarma ve yüzeysel rol yapma davranışlarının paralel aracılık rolünü ortaya koymak amacıyla tasarlanmıştır. Bu amaç doğrultusunda Türkiye’nin Doğu Anadolu bölgesinde yer alan orta ölçekli bir eğitim ve araştırma hastanesi çalışanları örneklem olarak ele alınmıştır. Kolayda örnekleme yöntemiyle 400 sağlık çalışanından veri toplanmıştır. Araştırma verileri için alan yazınında geçerliliği ve güvenirliliği test edilmiş ölçekler kullanılmıştır. Nicel veri toplama yönteminin kullanıldığı bu araştırma aynı zamanda tanımlayıcı, ilişki aracı ve kesitsel olarak tasarlanmıştır. Araştırma bulguları değerlendirildiğinde sağlık çalışanlarının zorunlu vatandaşlık davranışları ile hizmet süreçlerini sabote etme davranışları, sosyal kaytarma eğilimleri ve yüzeysel rol yapma durumları arasında pozitif yönlü anlamlı ilişkiler; sosyal kaytarma eğilimleri ile yüzeysel rol yapma eğilimleri ve hizmet süreçlerini sabote etme davranışları arasında pozitif yönlü anlamlı ilişkiler ve yüzeysel rol yapma eğilimleri ile hizmet süreçlerini sabote etme eylemleri arasında pozitif yönlü anlamlı bir ilişki tespit edilmiştir. Ayrıca sağlık çalışanlarının zorunlu vatandaşlık davranışları ile hizmet süreçlerini sabote etme eğilimleri arasındaki ilişkide sosyal kaytarmanın ve yüzeysel rol yapma davranışlarının ayrı ayrı aracılık rolünün olduğu bulgulanmıştır. Son olarak sağlık çalışanlarının zorunlu vatandaşlık davranışları ile hizmet süreçlerini sabote etme eğilimleri arasındaki ilişkide sosyal kaytarmanın ve yüzeysel rol yapma davranışlarının paralel aracılık rolünün olduğu da tespit edilmiştir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
    • SDG 16 · Barış, Adalet ve Güçlü Kurumlar
    İncele
  • MakaleAçık Erişim2024
    Birinci Trimesterde Subkoryonik Hematomu olan Gebelerin Obstetrik Komplikasyonlarının ve sonuçlarının Değerlendirilmesi

    Kurnuç, Fatma Zehra; Naykı, Ümit Arslan; Balsak, Deniz; Balkan, Nazenin

    Amaç: Bu çalışmada, birinci trimesterde ultrasonografide subkoryonik hematomu olan gebelerin obstetrik komplikasyonlarının ve sonuçlarının değerlendirilmesi amaçlanmıştır. Yöntemler: Çalışmamıza, Mengücek Gazi Eğitim ve Araştırma Hastanesi Kadın Doğum Polikliniği’nde Ocak 2019 ile Kasım 2021 tarihleri arasında tekil gebeliği olan, servikal açıklığı bulunmayan ve ultrasonografide kanama alanı izlenen 14. gebelik haftasının altındaki hastalar dahil edilmiştir. Ultrasonografik olarak kanama alanı tespit edilen hastalar, takiplerinde vajinal kanama, pelvik ağrı olup olmamasına, kanama alanlarının lokalizasyonuna, hematom alanı hesaplamasına ve CRL (baş popo mesafesi) ile hematom boyutlarının oranlamasına göre gruplandırılarak her grubun ayrı ayrı gebelik prognozunu araştırmak için geçmiş hasta dosya kayıtları incelendi. Araştırma kapsamında ilk olarak hematom tespit edilen 1819 hasta tarandı ve ultrasonografide kanama alanı izlenen 334 hasta tespit edildi. Takiplerine devam etmeyen, gebeliği hastanemizde sonlanmayan ve belirtilen risk faktörleri olan hastalar dışlandı ve araştırma kapsamına 215 hasta alındı. Tüm veriler istatistiksel olarak analiz edildi. Bulgular: Hastaların komplikasyon oranı %60,9 olarak bulunmuştur. Komplikasyonlardan en sık %43,7 ile düşük, ardından %9,3 ile preterm doğum saptanmıştır. Düşüke etki eden faktörler araştırıldığında; CRL boyutunun hematomun yatay uzunluğuna oranına göre hesaplandığında ½ den fazla olanlarda ½ den az olanlara göre gebeliğin düşük ile sonuçlanmayıp gebeliğin devam etme olasılığını 2,923 kat artırmaktadır ve istatistiksel olarak anlamlı olduğu saptanmıştır. Düşük açısından, hematomun lokalizasyonu ve alanı arasında anlamlı bir fark tespit edilmedi. Subkoryonik hematomu olan gebelerde komplikasyona etki eden faktörler araştırıldığında; CRL boyutu ile hematomun yatay uzunluğunun oranının ½ den fazla olmasının ½ den az olmasına göre sağlıklı gebelik oluşma ihtimalini 2,325 kat artırdığı, CRL ile hematomun derinlik (longitudunal ) boyutuna oranının 1 den az olmasına göre 3-4 arasında olması sağlıklı gebelik oranını 3,439 kat oranında artırdığı ve 4 ten fazla olmasının ise 2,388 kat artırdığı saptanmıştır ve istatistiksel olarak anlamlı olduğu tespit edilmiştir. Sonuç: Çalışma sonucunda, gruplar arasında kötü obstetrik sonuç açısından anlamlı fark saptanmıştır. CRL boyutunun hematom boyutu ile oranlandığı hasta gruplarında düşük ve komplikasyon sonuçlarını öngörmede istatistiksel olarak anlamlı etkinliği olduğu gösterilmiştir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2024
    Symptomatic and morphometric analysis of lumbosacral transitional vertebrae: assessments by age and gender

    Bingöl, Koray; Arslan, Mithat Kerim

    Aim: Lumbosakral transitional vertebrae (LSTV) are anatomical variations where a vertebra exhibits characteristics of both lumbar and sacral vertebrae. This study aims to assess anatomical changes in LSTV patients by measuring intervertebral disc height (IVDh), vertebral foramen anteroposterior diameter (FVAPd), and intervertebral foramen height (FIVh), with consideration of age and gender differences. Material and Methods: This retrospective study included 274 patients diagnosed with LSTV. All MRI images were acquired with a 1.5T MRI machine and a 32-channel lumbar coil. The presence of LSTV, forming the morphological data, was identified from coronal and sagittal reformat images and was classified as either lumbarization or sacralization. Morphometric data (IVDh, FIVh and FVAPd) were acquired from axial, sagittal, and coronal planes using both soft tissue and bone window settings. Results: The mean patient age was 41.6±13.0 years, with a female majority (55.8%). LSTV was predominantly lumbarization (96.4%), with sacralization in the remaining cases. The overall mean FVAPd was 11.2±2.4 mm, mean IVDh was 9.1±1.8 mm, and mean FIVh was 18.8±2.4 mm on the right and 19.1±2.4 mm on the left. IVDh levels were consistent across age groups, while FVAPd values were similar between genders. Patients aged 40 and under had higher FVAPd and FIVh levels, and male patients had higher IVDh and FIVh levels compared to females. Conclusions: The morphometric characteristics of LSTV may vary according to age and gender. Considering these factors in accurately identifying the anatomical variations of LSTV may play a significant role in determining appropriate treatment and management strategies.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Does the incidence of post-COVID pulmonary complications in vaccinated individuals correlate with the types of vaccines they received?

    Çınar, Hasibe Gökçe; Memis, Kemal Bugra

    Aim: Although several research have been undertaken to investigate the impact of the vaccination on long Coronavirus Disease 2019 (COVID-19) syndrome or post-acute sequelae, there is a lack of published evidence on the long-term effects of vaccines on lung-sequelae-related disease. Considering the limited global COVID-19 vaccine distribution, it is essential to establish the impact of vaccination in reducing pulmonary complications. Turkey has been offering COVID-19 vaccines from two platforms, including BNT162b2 (Pfizer-BioNTech, mRNA vaccine) and CoronaVac (Sinovac, inactivated vaccine). This study aimed to evaluate the efficacy of BioNTech and Sinovac vaccines in reducing post-COVID-19 pulmonary complications in individuals. Material and Methods: A total of 94 patients COVID-19 pneumonia patients who were categorized based on the quantity of BioNTech or Sinovac vaccines they received before their first COVID-19 infection were included. The inclusion criteria consisted of a confirmed diagnosis of COVID-19 pneumonia through polymerase chain reaction testing, availability of the mentioned before and follow-up computed tomography scans, and administration of at least one dose of vaccine. Results: The number of complications in patients fully vaccinated with Sinovac and who experienced post-COVID lung complications was significantly greater than in those vaccinated with BioNTech. The C-reactive protein and D-Dimer measurements of individuals who experienced complications in the Sinovac vaccinated group were significantly elevated on the index date. Conclusion: The quantity of lung sequelae after COVID and laboratory parameters indicating this result were found to be higher in inactivated virus vaccines than in mRNA vaccines. This suggests that the protection of inactivated vaccines may be insufficient in severe cases.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2024
    The Relationship Between Fear of Death and Healthy Lifestyle Behaviors in Individuals Having Percutaneous Coronary Intervention

    Göktaş, Ahmet; Önen, Cihan; Huyut, Mehmet Tahir; Okutan, Şerafettin

    Objective: The study aims to investigate the relationship between fear of death and healthy lifestyle behaviors in individuals undergoing percutaneous coronary intervention. Materials and Methods: The sample number was determined to be 109. The study was carried out in the angiography unit and cardiology clinics of a hospital. Data were collected using the Thorson-Powell Death Anxiety and Healthy Lifestyle Behaviors II Scales. Results: The patients' death anxiety scale score was 55.17±11.52 and their healthy lifestyle behavior scale score was 123.51±14.56. A negative relationship (r = -0.683, p = 0.003) was found between death anxiety and healthy lifestyle behavior scales. As death anxiety increased, healthy lifestyle behaviors decreased. A negative correlation was found between death anxiety level and physical activity (r = -0.720, p=0.002). As physical activity decreased, death anxiety level increased. Conclusions: In order for patients to experience less death anxiety, the importance of a healthy lifestyle, such as diet, exercise, spiritual development, stress management, and a healthy social life, should be known. Healthy lifestyle education programs should be applied to patients. To ensure permanence, patients should be supported with visuals and brochures, and training should be repeated.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2024
    Detection of Lung Cancer Cells Using Deep Learning Methods

    Akar, Funda; Genç, Muhittin

    Lung cancer stands out as a high mortality, fatal disease worldwide. Early diagnosis is crucial for effective treatment of this disease; however, treatment options can be limited when it is often diagnosed in advanced stages. This study examines the role of artificial intelligence (AI) techniques in early diagnosis of lung cancer and emphasizes the advantages it provides. Particularly, the ability of deep learning algorithms to extract meaningful features from complex datasets indicates significant potential for detecting early stages of lung cancer. In this context, it is anticipated that AI-supported diagnostic systems have the potential to significantly improve lung cancer diagnostic methods by reducing the workload of radiologists and increasing accuracy rates. In this study, a total of 6 datasets were obtained by applying Gabor filter and Histogram Equalization+CLAHE filter to original datasets. The results obtained in the diagnosis of lung cancer using Convolutional Neural Networks (CNN) and YOLO algorithms are evaluated in two different categories. One of these categories is the investigation of the effect of image preprocessing methods. The other is the investigation of the effect of dataset partitioning into training, testing, and validation on success. According to the results obtained, the highest success rate in terms of F1 Score for the CNN model was achieved in both dataset partitioning (70%-20%-10% and 60%-20%-20%) with the datasets subjected to Histogram Equalization+CLAHE filter. It was obtained as 99%. For the YOLO model, the highest success rate was determined as 96% F1 Score with the same preprocessing technique and dataset partition. The effect of image preprocessing and dataset partitioning on success is not as high in the YOLO model as it is in the CNN model.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    İncele
  • MakaleAçık Erişim2024
    Quantum Chemical Computations, Molecular Docking, and ADMET Predictions of Cynarin

    Yavuz, Sevtap Çaglar

    Cynarin (1,3-o-dicaffeoylquinic acid) is one of the biologically active functional food components which is the most well-known caffeoylquinic acid derivative found in artichoke. The structural and electronic features of cynarin compound were investigated theoretically using density functional theory (DFT). The highest occupied molecular orbital (HOMO) and the least occupied molecular orbital (LUMO) are the most significant orbitals in molecules, these orbitals are quite helpful to know several molecular features such as the chemical reactivity, kinetic stability, electronegativity, chemical potential, electrophilicity index, chemical hardness and softness and electronegativity. Molecular orbital analysis HOMO-LUMO was used to explore the stability of the molecule. Moreover, physicochemical properties, drug-likeness, and toxicity estimation of the cynarin compound were appraised owing to ADMET (including absorption, distribution, metabolism, excretion, and toxicology). Molecular docking was carried out to examine the biological activity of the cynarin compound. 5A19, a liver cancer biomarker, is human methionine adenosyl-transferase enzymes. Cynarin-methionine adenosyl-transferase enzyme binding energy value was calculated as -7.9 kcal/mol. As a result, this in silico study confirmed that cynarin has the potential to be a drug by revealing its protective effect against liver diseases.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Potential Role of Laurus nobilis Essential Oil in Reducing Indomethacin-Induced Gastric Ulcer in Rats

    Karakuş, Selcan; Kurt, Nezahat; Issin, Gizem; Danışman, Ferdane; Ustundag, Hilal; Taş, Necip Gökhan

    Objective: This study aimed to investigate the gastroprotective effects of Laurus nobilis leaves essential oil (LANO) against indomethacin (INDO)-induced gastric ulcers in rats. Materials and Methods: In this study, an indomethacin-induced gastric ulcer model was employed. 30 Sprague-Dawley rats were divided into five groups (n=6): Control, LANO, INDO, INDO with famotidine (FAM), and INDO with LANO. Indomethacin (25 mg/kg) induced ulcers, while LANO and FAM were administered by oral gavage at 200 mg/kg and 40 mg/kg, respectively. Gastric tissues underwent histopathological examination for ulceration, and biochemical assays measured total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and nitric oxide (NO) levels. Results: Compared to the INDO group, treatment with LANO significantly decreased the number of gastric ulcer foci. Biochemically, LANO moderated TOS and OSI levels and preserved TAS, indicating reduced oxidative stress. Additionally, LANO appeared to stabilize NO levels. These biochemical findings were corroborated by histopathological examination. Conclusions: The study's results indicate that LANO may be beneficial in protecting against NSAID-induced gastric damage. LANO's observed modulation of oxidative stress markers and NO levels suggests its potential role in managing gastric ulcers.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    The Impact of COVID-19 Pandemic on Patients’ Attitudes Towards Traditional and Complementary Medicine: A Cross-Sectional Study

    Gürsoy, Ersan; Karabaş, Bilal

    Objective: Our study aims to examine whether patients’ perspectives on traditional and complementary medicine (T&CM) are affected by the coronavirus disease-2019 (COVID-19) pandemic. Material and Methods: Our study is cross-sectional descriptive. The population consists of patients aged 18 years and older who applied to the family medicine outpatient clinic of a university hospital between January 2022 and June 2022. Healthcare workers were excluded from the study to avoid medical bias. A sociodemographic questionnaire consisting of 18 items and a T&CM Attitude Scale consisting of 27 items prepared by McFadden et al. were administered to the participants. A pilot study was conducted with 38 people. According to the pilot study results, the sample calculation was made, and the study was carried out with 450 people. Results: Post-COVID-19 scores were significantly higher in the T&CM Attitude Scale total score and in the sub-dimensions of “view of traditional medicine”, “dissatisfaction with modern medicine”, and “holistic view of health” (p<0.001). The increase in the total score on the T&CM Attitude Scale was more evident in those who had used any T&CM method before, in those whose family members had used the T&CM method, and in those who found T&CM methods useful (all p<0.001). There was no significant difference in the total score between those with COVID-19 infection and those without (p=0.215). Conclusion: The view for T&CM was found to increase positively after the COVID-19 pandemic, and this positive outlook was independent of being infected with COVID-19.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Dil ve konuşma bozukluğu tanısı olan ve tipik gelişim gösteren çocukların oyun davranışlarının incelenmesi

    Aral, Neriman; Aysu, Burçin; Aydogdu, Fatih; Barmak, Elife; Uysal, Halil Tayyip; Yılmaz, Semiha Bengisu

    Bu çalışmayla dil ve konuşma bozukluğu olan (konuşma sesi bozukluğu, akıcı konuşma bozukluğu ve gelişimsel dil bozukluğu) ve tipik gelişen çocukların oyun davranışlarının incelenmesi amaçlanmaktadır. Çalışma 36-71 ay arasında dil ve konuşma bozukluğu (DKB) olan 200 çocuk ve tipik gelişim gösteren 200 çocuk olmak üzere toplam 400 çocuk ve öğretmenleriyle yapılmıştır. Veri toplama aracı olarak “Genel Bilgi Formu ve "Oyun Davranışı Ölçeği" kullanılmıştır. DKB olan çocukların sessiz davranış ve tek başına oyun puan ortalamalarının tipik gelişim gösteren çocuklardan anlamlı düzeyde yüksek ve sosyal oyun puanları ise anlamlı düzeyde düşük bulunmuştur. Yaş değişkenine göre her iki grup arasında sessiz davranış, tek başına, paralel ve sosyal oyun puanları farklılaşmaktadır. Dil bozukluğu olan çocukların sessiz davranış puan ortalamaları konuşma sesi bozukluğu olan çocuklardan anlamlı düzeyde yüksekken; konuşma sesi bozukluğu olan çocukların sosyal oyun puan ortalamaları ise dil bozukluğu olan çocuklara göre anlamlı düzeyde yüksek saptanmıştır. Bu bulgular doğrultusunda dil ve konuşma bozukluğu olan çocukların, tipik gelişen akranlarına göre oyun becerilerinde farklılıklar olduğu görülmüştür. Araştırma sonucunda; DKB’li çocuklarla çalışan klinisyenlerin, çocukların dil ve konuşma becerilerini değerlendirmenin yanı sıra oyun davranışlarını da değerlendirmesi önerilmekte, değerlendirme sonuçlarının ise bu çocuklar için oluşturulacak müdahale ve terapi süreçlerine dahil edilmesi önemli görülmektedir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 4 · Nitelikli Eğitim
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  • MakaleAçık Erişim2024
    The Prediction of Peer Bullying in Adolescents by Individual and Environmental Variables

    Haspolat, Namik Kemal; Özer, Abdulkadir

    This study aimed to examine the effects of individual (age, gender, frustration of basic psychological needs) and environmental (adolescent-parental relationships, friendship relations, victimization) variables on peer bullying in adolescents. The study group consisted of 831 middle and high school students, 516 girls (62.1%), and 315 boys (37.9%). The research data were obtained using the Personal Information Form, Friendship Qualities Scale, Adolescent-Parental Relationships Scale, Peer Bullying Scale Adolescent Form, Basic Psychological Needs Satisfaction, and Frustration Scale. Hierarchical Regression Analysis was used to analyze the data. According to the results obtained from the study, gender, age, frustration of basic psychological needs, adolescent-parent relationships, and victimization variables were found to be significant predictors of adolescents' bullying levels. In the model, the friendship relationships variable is not a significant predictor. In the study, it was determined that victimization was the strongest predictor, and the model explained approximately 34% of the bullying level of adolescents. The results obtained from this study show that individual and family-participated interventions can be effective in preventing peer bullying in adolescents.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 16 · Barış, Adalet ve Güçlü Kurumlar
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  • MakaleAçık Erişim2024
    The effects of cetuximab with agomelatine on gene expression in colon cancer cells

    Erbaş, Elif; Kara, Adem; Ustundag, Hilal; Albayrak, Kevser; Köse, Rukiye

    This study investigated the combined effects of agomelatine, a melatonergic antidepressant, and cetuximab, an EGFR inhibitor, on the colorectal cancer cell line (Caco-2). Caco-2 cells were treated with agomelatine (0.3 μg/ml and 3 μg/ml) and cetuximab (50 μg/ml), individually and in combination, for 24 and 48 hours. Cell viability was assessed using the MTT assay. Gene expression analysis of EGFR, BCL2, PIK3CA, BAX, mTOR, and AKT3 was performed using real-time PCR. All treatment groups showed significant decreases in cell viability compared to the control (p&lt;0.05), with enhanced effects in combined treatments. EGFR expression was significantly reduced in drug-treated groups, particularly with cetuximab (p&lt;0.05). While changes were observed in BCL2, PIK3CA, BAX, mTOR, and AKT3 expression, these were not statistically significant (p&gt;0.05). This study demonstrates the potential synergistic cytotoxic effects of agomelatine and cetuximab on Caco-2 colorectal cancer cells. The significant reduction in EGFR expression suggests a potential mechanism of action. These findings provide insights into combining chemotherapeutic agents with drugs addressing circadian rhythm disorders in CRC treatment strategies. Further research is warranted to elucidate the clinical implications of these observations.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Neuroprotective effect of chlorzoxazone against glutamate toxicity in rat primary cortex neuron culture

    Hacimuftuoglu, Ahmet; Çıçek, Betül; Yeni, Yeşim

    Glutamate (Glut) toxicity is one of the main causes of neurological diseases. Chlorzoxazone (CZ) is a muscle relaxant used to decrease pain and inflammation associated with acute and chronic twists and bruises. Here, we objected to research the neuroprotective effect of CZ applied to reverse Glut-induced neurodegeneration in the neonatal cerebral cortex through anti-inflammatory and antioxidant mechanisms. Neonatal cortical neurons were exposed to Glut and different doses of CZ (10, 20, and 40 µM) were applied to assess the effect of CZ on Glut toxicity. We then examined changes in cell viability, inflammation, and oxidative stress. Our cell viability analysis showed that CZ protected cells from Glut-induced neuronal damage. In addition, the neuroprotective properties of CZ were evaluated by examining oxidative and antioxidant parameters such as MDA, MPO, CAT, GSH, GPx, and SOD. In line with the data obtained, it was observed that the cell viability rate decreased to 60% in the Glut group. However, with CZ application, the most significant increase in cell viability was seen at the 40 μM dose (86%), while the least increase was seen at 10 μM CZ (77%). It also proved that CZ increased the activity of antioxidant parameters while reducing oxidative parameters and inflammation. Therefore, the present findings collectively demonstrated that CZ potently inhibits Glut-induced injury in neonatal cortical neurons. The present work is the initial to show the protective effect of CZ in neonatal cortical neurons exposed to Glut excitotoxicity and suggesting that CZ may be used as a therapeutic agent.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • Derleme MakaleAçık Erişim2024
    Kronik obstrüktif akciğer hastalığında rehabilitasyon yaklaşımları ve kırılganlık: geleneksel derleme

    Tütün Yümin, Eylem; Uysal, Mert; Can, Berker; Uncu, Ahmet; Sari, Nurgul; Çevik, Ramazan

    Kronik obstrüktif akciğer hastalığı (KOAH), yüksek prevalansı ve artan insidansı ile önemli bir küresel sağlık sorunudur. KOAH, önemli sosyal ve ekonomik yüklere neden olan dünya çapında önde gelen mortalite ve morbidite nedenidir. KOAH’lı bireylerde dispne, öksürük, balgam, hırıltılı solunum sıkça gözlenen semptomlardır. Yaş ve hastalık ilerledikçe bilişsel fonksiyonlarda gerileme, kas kütlesinde azalma, sarkopeni ve kırılganlık da tabloya eşlik edebilmekte ve hastaların fonksiyonel kapasitesi azalmaktadır. Özellikle tabloya kırılganlık tanısının da eklenmesiyle KOAH’lı bireyler günlük yaşam aktivitelerini sürdürmekte zorlanmakta ve yaşam kalitesi olumsuz etkilenmektedir. Bu nedenle KOAH’lı bireylerin kırılganlık bakımından kapsamlı olarak değerlendirilmesinin bireye özgü pulmoner rehabilitasyon programının oluşturulmasında önemli olacağı görüşündeyiz.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Analysis of volatile compounds of alcea calvertii boiss. and its antimicrobial, anticholinesterase, and antityrosinase potency

    Sener, Sila Ozlem; Karaoğlu, Şengül Alpay; Aliyazicioglu, Rezzan; Çolak, Nevin Ulaş; Kandemir, Ali; Özgen, Ufuk; Badem, Merve; Kanbolat, Şeyda

    The research aimed to analyze the volatile compounds by using SPME-GC-MS and to detect anticholinesterase, antityrosinase, and antimicrobial potential of metanol extract of Alceacalvertii Boiss., an endemic species for Türkiye. The inhibitory effects of tyrosinase, acetylcholinesterase, and butyrylcholinesterase of the plant were determined by spectroscopic technique and the plant’s antimicrobial activity was assessed using the agar diffusion method. A total of 18 volatile compounds were specified belonging to terpenes classes. o-cymene (10.60%) and sesquicineole (15.55%) were detected as major volatile components of the species by the SPME-GC-MS technique. Meaningful antimicrobial activity was observed on Candida tropicalis, Enterococcus faecalis, Escherichia coli, Mycobacterium smegmatis, Staphylococcus aureus, and Pseudomonas aeruginosa. The half maximal inhibitory concentration (IC50) value of the plant was determined 60.12 ± 1.75 μg/mL as a result of tyrosinase assay. IC50 value was found 111.54 ± 1.75 μg/mL, according to butyrylcholinesterase inhibition studies. Considering all the findings, it has been determined that the plant includes diverse volatile compounds and showed promising antimicrobial, tyrosinase inhibitory, and moderate butyrylcholinesterase inhibitory effects so Alceacalvertii may be the up-and-coming source of natural medicine for microbial and dermatological diseases although limited to its effects for Alzheimer's disease.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleYalnız künye2024
    Effects of Transcranial Direct Current Stimulation on Motor and Cognitive Dysfunction in an Experimental Traumatic Brain Injury Model

    Akcay, Guven; Demirdogen, Filiz; Gul, Tuba; Yilmaz, Ali; Kotan, Dilcan; Karakoc, Esra; Ozturk, Huseyin Emre; Celik, Cagla; Celik, Haydar; Erdem, Yavuz

    AIM: To investigate the therapeutic and neuroprotective effects of transcranial direct current stimulation (tDCS) application on the traumatic brain injury (TBI)-induced glutamate and calcium excitotoxicity and loss of motor and cognitive functions. MATERIAL and METHODS: Forty rats were equally divided in the sham, TBI, tDCS + TBI + tDCS, and TBI + tDCS groups. Mild TBI was induced by dropping a 450-g iron weight from a height of 1 m onto the skull of the rats. The tDCS + TBI + tDCS group was prophylactically administered 1 mA stimulation for 30 min for 7 days starting 5 days before inducing TBI. In the TBI + tDCS group, tDCS (1 mA for 30 min) was administered 2 h after TBI, on days 1 and 2. Cognitive and locomotor functions were assessed using the novel object recognition and open field tests. The calcium, glutamate, and N-methyl-D-aspartate receptor 1 (NMDAR1) levels in the hippocampus were measured using enzyme -linked immunosorbent assay. RESULTS: Although the motor and cognitive functions were substantially reduced in the TBI group when compared with the sham, they improved in the treatment groups (p<0.05). The calcium, glutamate, and NMDAR1 levels were considerably higher in the TBI group than in the sham (p < 0.001). However, they were considerably lower in the tDCS + TBI + tDCS and TBI + tDCS groups than in the TBI groups (p < 0.05). In particular, the change in the tDCS + TBI + tDCS group was higher than that in the TBI + tDCS group. CONCLUSION: Application of tDCS before the development of TBI improved motor and cognitive dysfunction. It demonstrated a neuroprotective and therapeutic effect by reducing the excitotoxicity via the regulation of calcium and glutamate levels.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC-FID, and LC-HRMS chromatographies

    Gulcin, Ilhami; Ozden, Eda Mehtap; Mutlu, Muzaffer; Mirzaee, Ziba; Bingol, Zeynebe; Köksal, Ekrem; Alwasel, Saleh; Goren, Ahmet C.

    Background This study investigated the antidiabetic and antioxidant properties of hemp seed oil using various bioanalytical methods. Furthermore, this study determined the suppressive properties of hemp seed oil on alpha-amylase, acetylcholinesterase and carbonic anhydrase II that purified by the sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatoghraphy, all of which are related to different metabolic diseases. Moreover, the phenolic concentration in the essential oil was quantified through LC-HRMS chromatography. Thirteen distinct phenolic compounds were detected in hemp seed oil. Additionally, both the chemical components and quantity of essential oils within hemp seed oil were assessed through GC-FID and GC/MS analyses. Results The predominant essential oils in hemp seed oil included linoleoyl chloride (34.62%), linoleic acid (33.21%), and 2-4-di-tert-butylphenol (5.79%). Hemp seed oil's ability to scavenge radicals was studied through the use of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazil bioanalytical radical scavenging methods. The results unveiled its potent radical-scavenging properties, with an 46.20 mu g/mL for 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals and IC50 of 9.76 mu g/mL for 1,1-diphenyl-2-picrylhydrazil radicals. The investigation also extended to explore the reducing capabilities of Fe3+-2,4,6-tri(2-pyridyl)-S-triazine, copper (Cu2+), and iron (Fe3+). Hemp seed oil demonstrated notable inhibitory effect against alpha-amylase (IC50: 545.66 mu g/mL), achethylcholinesterase (IC50: 28.00 mu g/mL), and carbonic anhydrase II (IC50: 322.62 mu g/mL). Conclusions This interdisciplinary research will prove valuable and set the stage for future investigations into the antioxidant characteristics and enzyme inhibition patterns of plants and plants oils that hold medical and industrial significance.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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  • MakaleAçık Erişim2024
    Assessment of the potential interactions between favipiravir and radiocontrast agents

    Aydin, Sonay; Aydin, Ozlem Celik; Yazar, Mesut Furkan; Aydemir, Huseyin; Kantarci, Mecit; Barun, Sureyya

    BACKGROUND In cases of coronavirus disease 2019 ( COVID- 19), favipiravir is commonly included to the therapy regimen. Drug interactions between favipiravir and other COVID-19 therapy drugs are frequently researched. However, no research on possible drug interactions between Favipiravir and radiocontrast agents, which have become almost crucial in diagnostic processes while not being part of the treatment, has been found. AIM To determine potential medication interactions between Favipiravir and radiocontrast agents. METHODS The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) test while taking the medicine. The computerized patient files of the cases included in the study, as well as the pharmacovigilance forms in the designated hospital, were evaluated for this purpose. RESULTS The study included the evaluation of data from 1046 patients. The study sample's mean age was 47.23 +/- 9.48 years. The mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions (P = 0.003). When evaluated with logistic regression analysis, a 1-year raises in age increases the risk of developing drug interactions by 1.63 times (P = 0.023). There was no statistically significant difference in the occurrence of medication interactions between the sexes (P = 0.090). Possible medication interactions were discovered in 42 cases (4%). CONCLUSION The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values, as well as an increase in the frequency of nausea and vomiting. The majority of drug interactions discovered were modest enough that they were not reflected in the clinic. Drug interactions become more common as people get older.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
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